ADPT - Adaptive Biotechnologies Announces New Data Highlighting the Clinical Relevance of MRD Testing with clonoSEQ® in Patients with Blood Cancers at the 65th ASH Annual Meeting | Benzinga
- Treatment adapted studies show the potential for MRD assessment to guide the personalization of blood cancer care
- New data demonstrates MRD assessed from blood in multiple myeloma may be an indicator of early response
SEATTLE, Dec. 09, 2023 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced new data demonstrating the expanding use of Adaptive's next-generation sequencing (NGS)-based clonoSEQ® test in assessing minimal residual disease (MRD) in blood cancer patient care and in clinical trials. The data are being presented in more than 30 abstracts at the 65th Annual Meeting of the American Society of Hematology (ASH), December 9-12 in San Diego, California.
Minimal residual disease, also known as measurable residual disease, refers to the residual malignant cells that can be present in the body after treatment at very low levels and can only be identified by highly sensitive tests. clonoSEQ, which is the only FDA-cleared test for MRD assessment in lymphoid malignancies, is highly accurate, sensitive, and standardized compared to other technologies used for disease burden assessment.
"The already-substantial body of evidence supporting clonoSEQ's prognostic value and clinical actionability is expanding in several important ways at ASH this year," said Susan Bobulsky, Senior Vice President, Diagnostics, Adaptive Biotechnologies. "We are pleased to see many studies presented elucidating the role of clonoSEQ MRD testing in blood – both in multiple myeloma, where blood-based testing can expand patient access to MRD insights, and in a variety of subtypes of non-Hodgkin lymphoma, such as mantle cell lymphoma, where we see promising evidence of the role MRD may play in informing management."
Data generated from the University of Chicago found that MRD status determined through clonoSEQ testing of the peripheral blood (PB) early in treatment was prognostic, while stratification by complete response (CR) was not. The data were presented in a poster presentation titled, Early Peripheral Blood Minimal Residual Disease Status by NGS in Patients with Newly Diagnosed Multiple Myeloma (MM) on a Phase 2 Trial Receiving Elotuzumab, Carfilzomib, Lenalidomide, and Dexamethasone (Elo-KRd) (Abstract 1982). The study evaluated matched bone marrow (BM) and PB samples from 31 newly diagnosed multiple myeloma patients at the end of cycle 4 of induction therapy. At this timepoint, MRD status from both PB and BM were similarly prognostic of patients' progression-free survival (PFS).
"We're encouraged to see the results of MRD testing with clonoSEQ in peripheral blood, which suggest that it is a prognostically significant assessment early in treatment," said Ben Derman, MD, Assistant Professor of Medicine at the University of Chicago. "The ability to gather early information from a blood test may be beneficial because bone marrow aspirate is not always sampled this early in treatment and an early indication of disease status may help inform downstream patient care decisions."
In an MRD-adapted study from the University of Wisconsin, MRD status assessed by clonoSEQ in peripheral blood was used to determine the relationship between early response and ...