ADCT - ADC Therapeutics Announces Abstracts Accepted for Presentation at the 65th ASH Annual Meeting | Benzinga
Presentations to highlight clinical utility of ZYNLONTA® (loncastuximab tesirine-lpyl) as a single agent and in combination
Oral presentation to include initial results of investigator-initiated Phase 2 study evaluating ZYNLONTA in combination with rituximab in patients with r/r follicular lymphoma
LAUSANNE, Switzerland, Nov. 02, 2023 (GLOBE NEWSWIRE) -- ADC Therapeutics SA (NYSE:ADCT) today announced abstracts on ZYNLONTA® (loncastuximab tesirine-lpyl) have been accepted for presentation at the 65th American Society of Hematology (ASH) Annual Meeting, which will be held in San Diego, California from December 9-12, 2023.
"We look forward to sharing insights from the growing body of research supporting the clinical utility of ZYNLONTA as a single agent and in combination with other treatments at the 65th ASH Annual Meeting," said Mohamed Zaki, MD, PhD, Chief Medical Officer of ADC Therapeutics. "In addition, we are encouraged by the initial results of an investigator-initiated Phase 2 study evaluating ZYNLONTA in combination with rituximab in patients with relapsed or refractory follicular lymphoma. The combination was well tolerated with a 95% overall response rate at week 12 and at week 21, an 86% metabolic complete response rate. We look forward to additional details to be shared during the oral presentation."
Details of the oral presentation of the investigator-initiated study:
Title: Limited Duration Loncastuximab Tesirine with Rituximab Induces High Complete Metabolic Response Rate in High-Risk Relapsed/Refractory Follicular Lymphoma – A Phase 2 Study
Abstract: 984
Session: 623. Mantle Cell, Follicular, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Targeted Therapy
Date and Time: Monday, December 11, 2023; 5:45 PM PT
Location: Manchester Grand Hyatt San Diego, Grand Hall C
Presenter: Juan Pablo Alderuccio, MD
Details of selected poster presentations:
Title: Early and Sustained Circulating Tumor DNA Response Dynamics after Loncastuximab Tesirine for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Abstract: 3133
Session: 627. Aggressive Lymphomas: Clinical and Epidemiological; Poster II Presentations
Date and Time: Sunday, December 10, 2023; 6:00 PM - 8:00 PM PT
Title: A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-Cell Non-Hodgkin Lymphoma (Glo-BNHL)
Abstract: 3097
Session: 626. Aggressive Lymphomas: Prospective Therapeutic Trials; Poster II Presentations
Date and Time: Sunday, December 10, 2023; 6:00 PM - 8:00 PM PT
Title: Loncastuximab Tesirine Demonstrated Substantial Single-agent Efficacy and Manageable Safety Profile in Heavily Pretreated Chinese Patients with Relapsed or Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)
Abstract: 4469
Session: 626. Aggressive Lymphomas: Prospective Therapeutic Trials; Poster III Presentations
Date and Time: Monday, December 11, 2023; 6:00 PM - 8:00 PM PT
Posters will be available in the poster exhibit halls (Halls G-H) at the San Diego Convention Center on December 10, 2023, from 9:00 AM - 8:00 PM PT (Poster II Presentations) and on December 11, 2023, from 9:00 AM - 8:00 PM PT ...