AVIR - Atea Pharmaceuticals Presents Promising Bemnifosbuvir and Ruzasvir Combination Data for the Treatment of Hepatitis C Virus at AASLD The Liver Meeting 2023 | Benzinga
First Clinical Data for Coadministration of Bemnifosbuvir and Ruzasvir Show Combination Was Well Tolerated in a Phase 1 Study
Plasma Pharmacokinetic (PK) Profiles of Bemnifosbuvir and Ruzasvir Were Not Affected by Food or Concomitant Dosing, Indicating Low Risk of Drug-Drug Interactions
Bemnifosbuvir and Ruzasvir are Potent Direct Acting Antivirals In Vitro with Favorable Antiviral Profiles Against HCV NS5A and NS5B Resistant Associated Variants (RAVs)
BOSTON, Nov. 13, 2023 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) (Atea), a clinical-stage biopharmaceutical company engaged in the discovery and development of oral antiviral therapeutics for serious viral diseases, today announced the presentation of two posters supporting the combination of bemnifosbuvir, an oral nucleotide polymerase inhibitor, and ruzasvir, an oral NS5A inhibitor, as a potential treatment for Hepatitis C Virus (HCV) at the American Association for the Study of Liver Diseases' (AASLD) The Liver Meeting 2023, being held from November 10-14, 2023 in Boston, MA.
"Results from these two presented studies further support the potential use of these two drug candidates in combination as a novel treatment for HCV. Phase 1 data demonstrate that coadministration of bemnifosbuvir and ruzasvir was well tolerated and not affected by food or concomitant dosing, indicating a low risk of drug-drug interactions," said Jean-Pierre Sommadossi, PhD, Chief Executive Officer and Founder of Atea Pharmaceuticals. "Moreover, in vitro data demonstrate that the combination of bemnifosbuvir and ruzasvir retained potent pan-genotypic antiviral activity against major HCV NS5A and NS5B resistance-associated variants and hard-to-treat sub-genotypes, which have been identified in certain HCV patients who have failed treatment with currently available therapies."
"We are very pleased with the substantial progress achieved in our Phase 2 combination study of bemnifosbuvir and ruzasvir for the treatment of HCV this year, and we expect to announce results from the 60-person lead-in cohort in early 2024," continued Dr. Sommadossi. "We look forward to progressing the clinical development of this potent direct-acting antiviral combination for the potential benefit for millions of patients who, despite available treatments for HCV, remain underserved."
Poster Number: 1879-A
Date and Time: Friday, November 10, 1:00 p.m. – 2:00 p.m.
Location: Hall A
Title: Lack of Pharmacokinetic Drug-Drug Interaction Between Bemnifosbuvir and Ruzasvir in Healthy Participants
Results from a Phase 1 study in 32 healthy adult participants demonstrate that the coadministration of bemnifosbuvir and ruzasvir was well tolerated, and plasma pharmacokinetic (PK) profiles remained generally unaffected by food or concomitant dosing, indicating a lack of drug-drug interaction between the two drug candidates. Two cohorts (n=16) were dosed at either (i) 550 mg bemnifosbuvir once-daily for 18 days and 180 mg ruzasvir once-daily starting at Day 7 through Day 18 or (ii) 180 mg ...