ITOS - iTeos Announces 2024 Strategic Priorities and Anticipated Milestones | Benzinga
- TIGIT program clinical data readouts anticipated in 2024, including two Phase 2 trials assessing belrestotug + dostarlimab in 1L NSCLC and 1L HNSCC
- Adenosine portfolio clinical data readouts anticipated in second half of 2024, including inupadenant's Phase 2 A2A-005 and EOS-984's Phase 1 trial
- EOS-984 preclinical data demonstrating novel mechanism of action in the adenosine pathway anticipated in second quarter of 2024
- Cash balance and investment balance of $644.9 million as of September 30, 2023 expected to provide runway through 2026
WATERTOWN, Mass. and GOSSELIES, Belgium, Jan. 08, 2024 (GLOBE NEWSWIRE) -- iTeos Therapeutics, Inc. (NASDAQ:ITOS), a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of immuno-oncology therapeutics for patients, today outlined business updates and strategic priorities for 2024.
"Over the past twelve months, the TIGIT competitive landscape has substantially evolved, further positioning iTeos and GSK as a potential leader with our high-quality TIGIT:PD-1 doublet, belrestotug + dostarlimab. We remain very encouraged by our progress ahead of a defining year for the company where we anticipate multiple data readouts across our IO portfolio throughout 2024, including three Phase 2 trials, one Phase 1 trial, and the unveiling of preclinical data and the novel mechanism of action for EOS-984," said Michel Detheux, Ph.D., president and chief executive officer of iTeos. "We believe 2024 will be an exciting year where we anticipate furthering our ambition to bring best- and first-in-class science to patients and validate our vision of building a pipeline of highly differentiated IO therapies."
Program Highlights
Belrestotug (EOS-448/GSK4428859A): IgG1 anti-TIGIT monoclonal antibody targeting first-line non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) in collaboration with GSK
- Preparation underway for Phase 3 registrational studies that will evaluate the belrestotug + dostarlimab doublet
- GALAXIES Lung-201: topline data from Phase 2 platform trial assessing belrestotug + dostarlimab doublet in first-line advanced/metastatic non-small cell lung cancer anticipated in 2024
- GALAXIES H&N-202: enrollment ongoing in Phase 2 platform study assessing belrestotug + dostarlimab doublet and a triplet with GSK's investigational anti-CD96 antibody (GSK'608) in first-line patients with PD-L1 positive recurrent / metastatic HNSCC
- TIG-006 HNSCC: topline data from Phase 2 expansion trial assessing belrestotug + dostarlimab doublet in first-line PD-L1 positive advanced or metastatic HNSCC anticipated in 2024
- TIG-006 mNSCLC: enrollment ongoing in Phase 2 expansion trial assessing belrestotug, dostarlimab, and chemotherapy triplet in first-line advanced or metastatic NSCLC
- TIG-007: the Company has deprioritized the Phase 1/2 TIG-007 trial assessing belrestotug and in combination with Bristol Myers Squibb's iberdomide due to the evolving treatment landscape in relapsed/refractory multiple myeloma (r/r MM)
- Continued advancement of Phase 1b trials exploring two novel triplets in advanced solid tumors: belrestotug + dostarlimab and GSK's investigational anti-CD96 antibody (GSK'608), and belrestotug + dostarlimab and GSK's investigational anti-PVRIG antibody (GSK'562)
Adenosine Pathway
Inupadenant (EOS-850): insurmountable small molecule antagonist targeting adenosine A2A receptor in second-line NSCLC
- A2A-005: topline data from the dose escalation portion of the Phase 2 trial with inupadenant and platinum-doublet chemotherapy in ...