MDNAF - Medicenna Announces Compelling Survival Benefit from Phase 2b Study of Bizaxofusp in Recurrent Glioblastoma at the 28th Annual Meeting of the Society for NeuroOncology | Benzinga
Single treatment of bizaxofusp doubled mOS (14.5 months vs. 7.2 months) irrespective of IL4R expression (high or low) compared to patients treated in the external control arm
Survival for bizaxofusp-treated patients increased 370% at Year 1 and increased more than 50% at Year 2
TORONTO and HOUSTON, Nov. 17, 2023 (GLOBE NEWSWIRE) -- Medicenna Therapeutics Corp. ("Medicenna" or the "Company") (TSX:MDNA, OTC:MDNAF), a clinical-stage immunotherapy company focused on the development of Superkines, today announced that a poster presentation and an oral summary highlighting longer term follow up results from the Phase 2b clinical trial of bizaxofusp (formerly known as MDNA55), the Company's first-in-class IL-4R targeted therapy for the treatment of patients with recurrent glioblastoma (rGBM), will be presented by Dr. Steven Brem, M.D. (Medical Director, Centre for Precision Surgery, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) at the Society for Neuro-Oncology (SNO) 2023 Annual Meeting, taking place from November 15-19, 2023, in Vancouver, Canada.
"Bizaxofusp represents an exciting new approach by demonstrating a dose-dependent effect on the receptor of IL-4, an immuno-suppressive cytokine. Further, use of bizaxofusp as a single agent or in combination could "flip the switch" on glioblastoma to convert it from an immunologically "cold" (unresponsive) tumor to one that is responsive, using convection enhanced delivery to "take the fight to the tumor". The data offers new hope for patients with glioblastoma who have few treatment options at recurrence," said Dr. Steven Brem.
"We are very encouraged by the 100% increase in survival benefit in unresectable rGBM achieved from a single treatment with bizaxofusp, even after 22 months of additional follow-up, which reinforces the robustness of the initial primary analysis," said Fahar Merchant, Ph.D., President and Chief Executive Officer of Medicenna. "In conjunction with regulators, our pioneering efforts have secured us a precedent-setting Phase 3 trial design in rGBM using an external control arm and are actively pursuing partnerships to further advance the bizaxofusp registrational study. Following the publication of our Phase 2b results in the journal Neuro-Oncology® earlier this year, it is a great privilege to be able share these updated 4-year follow-up results with the medical and scientific communities at SNO 2023."
4 Year Follow-up Results from the Phase 2b Study
This multi-center, open-label, single-arm Phase 2b study, enrolled and treated 44 patients with rGBM following surgery or radiotherapy ± adjuvant therapy or other experimental therapies. A separate analysis collected rGBM data from 81 patients who had contemporaneously received treatment at major ...