CRBP - Phase 1 Clinical Data for SYS6002 (CRB-701) to be presented at 2024 ASCO GU | Benzinga
NORWOOD, Mass., Jan. 23, 2024 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings, Inc. (NASDAQ:CRBP) ("Corbus" or the "Company"), announced today that the abstract for the first-in-human Phase 1 dose escalation study of SYS6002 (CRB-701) has been released, and the corresponding up-to-date data will be presented at the 2024 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU). The data referred to in the abstract dates to September of 2023; the upcoming presentation will include data as of December 2023. The study is being conducted by Corbus's partner CSPC Pharmaceutical Group in China. ASCO GU will be held January 25-27, 2024 in San Francisco, CA and online.
The abstract, a Phase 1 Dose-Escalation of SYS6002 (CRB-701), a next-generation Nectin-4 Targeting Antibody Drug Conjugate (ADC) by DingWei Ye, et al will be presented on Jan 26th between 11:30-1pm PST. SYS6002 (CRB-701) is currently being explored in a dose escalation on a Q3W schedule, with a view to reducing free-MMAE concentrations in plasma and thereby reducing the associated toxicities that are known to dose limit enfortumab vedotin (EV). Additionally, by administering SYS6002 (CRB-701) on a Q3W schedule there is an opportunity to increase clinical convenience and patient compliance. The dose escalation that will be presented currently spans 6 dose levels (0.2, 0.6, 1.2, 1.8, 2.7 & 3.6 mg/kg) and makes use of a Bayesian Optimal Interval (BOIN) design with accelerated titration. The trial is evaluating the safety and tolerability of SYS6002 (CRB-701) to determine the Maximum Tolerated Dose (MTD) and/or the Phase II dose in patients with advanced solid tumors ...