PRLD - Prelude Announces Multiple Clinical and Preclinical Poster Presentations at AACR-NCI-EORTC International Conference | Benzinga
WILMINGTON, Del. and BOSTON, Oct. 14, 2023 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated ("Prelude") (NASDAQ:PRLD), a clinical-stage precision oncology company, announces multiple clinical and preclinical posters at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, known as the Triple Meeting, from October 11 - 15, 2023 at the Hynes Convesntion Center in Boston, MA. The four Prelude poster presentations include data from two ongoing Phase 1 clinical trials for Prelude's CDK9 inhibitor, PRT2527, and CDK4/6 inhibitor, PRT3645, and two preclinical posters for our SMARCA2 degrader compound, PRT3789.
"This additional data from our solid tumor trial investigating our potent and selective CDK9 inhibitor, PRT2527, continues to support a best-in-class safety and target engagement profile for the molecule. A second Phase 1 clinical trial in patients with hematological cancers is also underway, with initial data expected in 1H 2024," stated Jane Huang, MD, President and Chief Medical Officer, Prelude Therapeutics.
Dr. Huang added, "We also presented our initial clinical data with our differentiated brain and tissue penetrant next generation CDK4/6 inhibitor, PRT3645, demonstrating a generally well-tolerated safety profile and high target inhibition reaching levels needed for efficacy in preclinical studies."
Clinical Poster Presentations:
Summary:
- The overall safety profile observed in this study supports further development of PRT2527 in combination with other targeted therapies in hematological malignancies.
Summary
- Initial clinical data from first three dose escalation cohorts (20, 40 and 80 mg QD) were reported.
- Treatment with PRT3645 was associated ...