STTK - Shattuck Labs to Present Topline Data from Phase 1 A/B Clinical Trial of SL-172154 in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Higher-Risk Myelodysplastic Syndromes (HR-MDS) Patients at the American Society of Hematology (ASH) 2023 Annua
– SL-172154 as monotherapy and in combination with azacitidine demonstrates anti-leukemic activity and an acceptable safety and tolerability profile –
AUSTIN, Texas and DURHAM, N.C., Nov. 02, 2023 (GLOBE NEWSWIRE) -- Shattuck Labs, Inc. (Shattuck) (NASDAQ:STTK), a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease, today announced the presentation of topline data from the dose escalation portion of its Phase 1 A/B clinical trial of SL-172154 as monotherapy and in combination with azacitidine (AZA) in primarily R/R AML and HR-MDS patients. These data will be featured in a poster presentation at the 65th ASH Annual Meeting, which is being held both virtually and in San Diego, CA from December 9-12, 2023.
"Response rates are historically low for heavily pretreated relapsed/refractory AML and HR-MDS patients. We were particularly pleased to observe initial anti-leukemic activity, unique pharmacodynamic activity, and an acceptable safety and tolerability profile for SL-172154 as monotherapy and in combination with azacitidine. We are excited to continue development of our unique bifunctional protein SL-172154, as we seek to improve the lives of patients with hematologic malignancies." said Dr. Lini Pandite, MBChB, M.B.A., Chief Medical Officer of Shattuck. "The observation of a monotherapy response, dose-dependent increases in serum cytokines, and accumulation of mature myeloid cells in bone marrow support a potential contribution of CD40 stimulation in these heme malignancies. Notably, preliminary data shows anti-leukemic effects detected in previously untreated TP53m-MDS and R/R AML patients. We look forward to sharing additional data from the frontline expansion cohorts later this year. Overall, we are encouraged by the growing body of data that further validates the unique mechanism of action of SL-172154 and its therapeutic potential to address the unmet needs for patients with AML and HR-MDS."
The full abstract (#4278) is accessible on the ASH Congress portal, and additional details are provided below.
- Title: Safety, Pharmacodynamic, and Anti-Tumor Activity of SL-172154 as Monotherapy and in Combination with Azacitidine (AZA) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Higher-Risk Myelodysplastic Syndromes/Neoplasms (HR-MDS) Patients (pts)
- Session Title: Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Poster III
- Presenter: Dr. Naval Daver
- Format: Poster Presentation
- Session Date: Monday, December 11, 2023
- Time: 6:00 PM - 8:00 PM PT
Key Takeaways: SL-172154 monotherapy response was observed in a heavily pretreated patient with R/R AML after just a single cycle of treatment, as well as early efficacy signals for SL-172154 in combination with AZA ...