TRVN - Trevena Announces TRV045 Presentation at the American College of Neuropsychopharmacology 62nd Annual Meeting | Benzinga
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Presentation highlighted promising results of TRV045 in nonclinical models of neuropathic pain including mechanical and cold-stimulus evoked nociceptive pain in a dose-related manner
TRV045 selectively targets the S1P1 receptor without associated lymphopenia
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CHESTERBROOK, Pa., Dec. 04, 2023 (GLOBE NEWSWIRE) -- Trevena, Inc. (NASDAQ:TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced a poster presentation at the 62nd Annual Meeting for the American College of Neuropsychopharmacology (ACNP). The conference is being held from December 3rd to 6th, 2023.
The poster discussed the potential utility of TRV045 for the treatment of chemotherapy-induced peripheral neuropathy (CIPN) using an established nonclinical model. CIPN is a nerve-damaging side effect of antineoplastic agents and occurs in approximately 70% of oncology patients undergoing chemotherapy. In addition, the Company is currently collaborating with the National Institutes of Health (NIH) to evaluate TRV045 for the potential treatment of epilepsy and as a nonopioid treatment for pain.
"These are compelling nonclinical findings for TRV045 that add to our growing understanding of its mechanism and the potential use in a range of CNS disorders, including neuropathic pain," said Mark Demitrack, M.D., Senior Vice President and Chief Medical Officer of Trevena, Inc.
Presentation Details
Presentation Title: "TRV045, a novel and selective S1P1 receptor modulator is efficacious in acute, chronic and prevention modes in mouse models of chronic neuropathy, without causing lymphopenia"
- Overall. Oral administration of TRV045 reduced mechanical and cold stimulus-evoked nociception in a dose-related manner in a mouse model of CIPN.
- Acute Reversal (Single and Multiple-Dose). These effects were demonstrated in single-dose acute reversal and were sustained following repeated administration of TRV045 for 14 days; effects were evident at doses of 3mg/kg and 10mg/kg.
- CIPN Prevention. In a prevention mode paradigm examining the potential effect of TRV045 to prevent the development of CIPN, TRV045 administered at 100mg/kg reduced both mechanical and cold hypersensitivity ...