SGIOF - ViiV Healthcare reports three-year switch data for Dovato in HIV

ViiV Healthcare presents three-year results from the TANGO study at IDWeek 2021, held September 29 - October 3. Findings showed that the 2-drug regimen (2DR) Dovato (dolutegravir/lamivudine) continued to demonstrate non-inferior efficacy and a high barrier to resistance compared to continuation of tenofovir alafenamide fumarate (TAF)-based regimens of at least three drugs in virologically suppressed adults living with HIV-1 who had not experienced prior virologic failure. At three years, no participants on dolutegravir/lamivudine (0% [0/369]) met confirmed protocol-defined virologic failure, versus three participants (<1% [3/372]) on the TAF-based regimen. No resistance mutations were reported in either arm. In the ITT-E population, both treatment arms showed a high proportion of participants with plasma HIV-1 RNA <50 c/mL, with dolutegravir/lamivudine demonstrating non-inferior virologic suppression to the TAF-based regimen (85.9% [317/369] vs 81.7% [304/372], respectively; adjusted difference: 4.2% [95% CI: -1.1%, 9.5%]). ViiV Healthcare is the HIV-focused joint venture between GlaxoSmithKline (NYSE:GSK), Pfizer

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ViiV Healthcare reports three-year switch data for Dovato in HIV