ABUS - Arbutus Announces Multiple Abstracts Accepted for Presentation at AASLD - The Liver Meeting® 2023 | Benzinga
Imdusiran data will be highlighted in late breaking presentation
WARMINSTER, Pa., Oct. 11, 2023 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (NASDAQ:ABUS), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, today announced that clinical data from the Company's lead HBV focused asset, imdusiran (AB-729), an RNAi therapeutic, and preclinical data from its oral PD-L1 inhibitor program, will be highlighted in oral and poster presentations, including a late breaking poster presentation at The American Association for the Study of Liver Diseases (AASLD) – The Liver Meeting® 2023, taking place from November 10-14, 2023 in Boston, MA.
Late-Breaking Abstract Acceptance:
Title: Preliminary Pharmacodynamics and Safety of Repeat Dosing of Imdusiran (AB-729) Followed by VTP-300 or Placebo in Virally-Suppressed, Non-Cirrhotic Subjects with Chronic Hepatitis B (CHB)
Authors: Man-Fung Yuen, Kosh Agarwal, Stuart K. Roberts, Gin-Ho Lo, Chao-Wei Hsu, Wan-Long Chuang, Chi-Yi Chen, Pei-yuan Su, Sam Galhenage, Sheng-Shun Yang, Deana Antoniello, Emily Thi, Susanne O'Brien, Louise Bussey, Elina Medvedeva, Timothy Eley, Deepa Patel, Tilly Varughese, Christine Espiritu, Sharie Ganchua, Christina Iott, Mark Anderson, Tiffany Fortney, Gavin Cloherty, Tom Evans, Karen Sims
Regular Abstract Acceptances:
Abstract Number: 45559
Title: Baseline Nucleotide Polymorphisms Within HBV Target Site in Chronic Hepatitis B Subjects Do Not Impact HBsAg Reductions Mediated by RNA Interference Therapeutic AB-729
Presentation Type: Poster #1459-C
Presentation Time: Friday, November 10: 12:00 – 1:00 PM ET – Poster Hall C
Authors: Christine Espiritu, Holly Micolochick Steuer, Andrzej Ardzinski, Varun Sharma, Timothy Eley, Karen D. Sims, Amy C.H. Lee, Rene Rijnbrand, Andrea Cuconati, Nagraj Mani, Angela M. Lam, Michael J. Sofia, and Emily P. Thi
Data Summary: Single nucleotide polymorphisms (SNPs) in the imdusiran (AB-729) HBV target site were identified in sequences obtained from a publicly available database and were observed at baseline in some chronic HBV subjects in AB-729-001. In vitro testing in an HBV cell-based model confirm retention of AB-729 activity against tested variants suggesting that these SNPs have no apparent influence on individual or mean HBsAg declines observed in subjects treated with AB-729.
Abstract Number: 46646
Title: Oral Small-Molecule Liver-Tropic PD-L1 Inhibitor Pharmacokinetics for the Treatment of Hepatocellular Carcinoma
Presentation Type: Poster #4209A
Presentation Time: Monday, November 13: 1:00 – 2:00 PM ET
Authors: Arpita Mondal, Emily P Thi, Ingrid Graves, Gavin Heffernan, Fran Xu, Seyma Ozturk, Amanda Pohl, Kristi Y Fan, Andrew Cole, Troy O Harasym, Angela M Lam, and Michael J Sofia
Data Summary: Treatment with oral small-molecule PD-L1 inhibitors possessing liver-tropic pharmacokinetic profiles was associated with increased efficacy and tumor clearance in a novel humanized orthotopic HCC mouse model. These data suggest that development of small-molecule PD-L1 inhibitors with biodistribution to the liver may provide benefit in the treatment of HCC.
Abstract Number: 40653
Title: Preliminary off-treatment responses following 48 weeks of vebicorvir, nucleos(t)ide reverse transcriptase inhibitor, and AB-729 combination in virologically suppressed patients with hepatitis B e antigen negative chronic hepatitis B: Analysis from an open-label Phase 2 study
Presentation Type: Oral Presentation
Session: Hepatitis B: New Therapies for HBV and HDV
Presentation Time: Sunday, November 12: 8:30 AM
Authors: Gerry MacQuillan, Magdy Elkhashab, Krasimir Antonov, Zina Valaydon, Scott Davison, Scott Fung, Catherine Vincent, Robert Bailey, Fei Chen, Curtis Cooper, Stuart Roberts, Marie-Louise Vachon, Carla S. Coffin, Gail Matthews, Mariana Radicheva, Steven J. Knox, Ran Yan, Emily P. ...