ARTL - Artelo Biosciences Presents Comparative Data from Key Preclinical Studies on ART12.11 at the 34th Annual International Cannabinoid Research Society Symposium | Benzinga
SOLANA BEACH, Calif., July 03, 2024 (GLOBE NEWSWIRE) -- Artelo Biosciences, Inc. (Nasdaq: ARTL), a clinical-stage pharmaceutical company focused on modulating lipid-signaling pathways to develop treatments for people living with cancer, pain, dermatologic and neurological conditions, today announced several presentations about ART12.11, Artelo's proprietary cocrystal combination drug candidate, were delivered at the 34th Annual International Cannabinoid Research Society (ICRS) Symposium held June 30 through July 5, 2024 in Salamanca, Spain.
Andrew Yates, Ph.D., Chief Scientific Officer at Artelo, presented results from two studies entitled, "ART12.11, a Novel Cannabidiol: Tetramethylpyrazine Cocrystal, Demonstrates a Unique Pharmacokinetic Profile," and "ART12.11, a Novel Cannabidiol: Tetramethylpyrazine Cocrystal, Demonstrates a Pharmacokinetic Profile Comparable with Epidiolex® in Rats," respectively. Matthew Jones, a member of the laboratory of Dr. Steven Laviolette at the University of Western Ontario, Canada, delivered the oral presentation "A Novel Cannabidiol: Tetramethylpyrazine (ART12.11, CBD:TMP) Cocrystal Improves the Efficacy and Bioavailability of Cannabidiol to Induce Anxiolytic and Anti-Depressant Effects."
Rodent pharmacokinetic data demonstrated that oral administration of an aqueous suspension of ART12.11 leads to increased plasma levels of CBD and its metabolites compared to CBD in the same formulation. This pharmacokinetic profile could not be replicated with coadministration of CBD and TMP. Furthermore, orally administered ART12.11 demonstrated similar plasma levels of CBD and its metabolites as an Epidiolex-like formulation in fed rodents. These results were obtained with an unoptimized aqueous suspension of ART12.11. Artelo is currently conducting drug formulation studies in order to optimize the oral solid delivery of ART12.11.
In the pharmacodynamic study performed at the laboratory of Dr. Laviolette, oral administration of ART12.11 significantly reduced a range of anxiety and depressive symptoms in chronically stressed rats. These effects were not significantly observed with either Cannabidiol (CBD) ...