ARVN - Arvinas Announces Upcoming Presentations at the 2024 American Society of Clinical Oncology Annual Congress | Benzinga
NEW HAVEN, Conn., May 23, 2024 (GLOBE NEWSWIRE) -- Arvinas, Inc. (NASDAQ:ARVN) today announced that two abstracts, including one for ARV-766 in prostate cancer and one for TACTIVE-K, a Phase 1b/2 clinical trial with vepdegestrant, a novel investigational oral PROteolysis Targeting Chimera (PROTAC®) ER degrader, in combination with Pfizer's atirmociclib (PF-07220060), an investigational CDK4 inhibitor, were accepted for presentation at the 2024 American Society of Clinical Oncology Annual Congress held May 31 to June 4, 2024, in Chicago, IL.
Presentation details are as follows:
Title: ARV-766, a PROteolysis TArgeting Chimera (PROTAC) androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC): initial results of a phase 1/2 study
Presentation Type and Abstract Number: Rapid Oral Abstract, 5011
Date: Monday, June 3, 2024
Time: 1:15 p.m. — 2:45 p.m. CDT
Category: Genitourinary Cancer—Prostate, Testicular, and Penile
Title: TACTIVE-K: phase 1b/2 study of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, in combination with PF-07220060, a cyclin-dependent kinase (CDK)4 inhibitor, in ER+/human epidermal growth factor receptor 2 (HER2)- advanced breast cancer
Presentation Type and Abstract Number: Trial-in-Progress (TiP) TPS1131, Poster 103b
Date: Sunday, June 2, 2024
Time: 9:00 a.m. — 12:00 p.m. CDT
Category: Session Type and Title: Poster Session – Breast Cancer—Metastatic
Abstracts are now available via the official ASCO Annual Congress website here.
About ARV-766
ARV-766 is an investigational, orally bioavailable PROTAC protein degrader designed to selectively target and degrade the androgen receptor (AR). Preclinically, ARV-766 has demonstrated activity in models of wild type androgen receptor tumors in addition to tumors with AR mutations or amplification, both common potential mechanisms of resistance to currently available AR-targeted therapies.
In April 2024, Arvinas entered into a transaction with Novartis that included ...