IMRX - Immuneering Presents Preclinical Data Demonstrating Encouraging Anti-Tumor Activity for IMM-1-104 and IMM-6-415 at AACR-NCI-EORTC Conference | Benzinga
– Expanded benchmarking of IMM-1-104 as a single agent across more than 190 patient-aligned models in humanized 3D-tumor growth assays demonstrated high sensitivity in a wide range of MAPK-driven tumor types, including models of RAS and RAF mutant melanoma, pancreatic cancer, and lung cancer
– IMM-1-104 in combination with gemcitabine or paclitaxel drove enhanced anti-tumor activity in humanized 3D-tumor growth assays across multiple pancreatic cancer models
– Strength of preclinical activity data together with encouraging tolerability results previously disclosed from the Phase 1a clinical trial provides strong rationale to evaluate IMM-1-104 in combination regimens while continuing to pursue a monotherapy strategy
– Benchmarking of IMM-6-415 as a single agent across more than 60 patient-aligned models in humanized 3D-tumor growth assays demonstrated high sensitivity in a wide range of MAPK-driven tumor types, including models of RAS and RAF mutant disease
– IMM-6-415 in combination with encorafenib drove deeper regressions and superior durability versus binimetinib plus encorafenib when compared head-to-head in animal models of RAF mutant melanoma and colorectal cancer; IND filing expected in 4Q 2023
CAMBRIDGE, Mass., Oct. 12, 2023 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a clinical-stage oncology company developing medicines for broad populations of cancer patients with an initial aim to develop a universal-RAS therapy, today presented encouraging preclinical data for both IMM-1-104, its lead clinical-stage program, and IMM-6-415 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, taking place October 11-15, 2023 in Boston, Massachusetts.
"Today we are sharing new preclinical data that further support the potential of IMM-1-104 and IMM-6-415 as single agents and in combination regimens across a wide array of MAPK-driven tumor types, including those with RAS or RAF mutations," said Ben Zeskind, Ph.D., Co-founder and Chief Executive Officer of Immuneering. "Our goal is to help broad populations of cancer patients achieve better responses. The opportunity to advance our promising monotherapy programs while also targeting new opportunities in combination therapy could position us to develop safer and more effective treatment options for an even broader range of patients. Today's findings add cytotoxic agents and RAF inhibitors to the list of promising combinations, building on our previously disclosed data supporting combinations with KRAS-G12C inhibitors and immuno-oncology agents. Tolerability is important for successful combinations, and we designed IMM-1-104 and IMM-6-415 with a unique deep cyclic inhibition mechanism that aims to provide both good tolerability and broad activity in MAPK-driven tumors. We believe that IMM-1-104 and IMM-6-415, alone, and in combination with other agents, have the potential to bring significant benefit to broad populations of patients with RAS or RAF mutant cancers."
Details for the poster presentations are as follows:
Title: Predicting activity of IMM-1-104 as single agent and in combination for patients with RAS or RAF mutant tumors
- Anti-tumor activity of IMM-1-104 was characterized in 193 tumor models spanning 20 distinct tumor types in the humanized 3D-tumor growth assay (3D-TGA) using cancer-specific, patient-aligned cell lines.
- IMM-1-104 demonstrated diverse responses across a wide range of MAPK-driven tumor types, including those with RAS or RAF mutations.
- Pharmacogenomic data were used to generate a model predictive of response to IMM-1-104 and identify biomarker-aligned patient subpopulations.
- Sensitivity to IMM-1-104 (IC50 < 1uM) tested in 3D-TGA cell lines ...