IOBT - IO Biotech Presents Three Posters at the Society for Immunotherapy of Cancer's (SITC) 38th Annual Meeting | Benzinga
NEW YORK, Nov. 01, 2023 (GLOBE NEWSWIRE) -- IO Biotech (NASDAQ:IOBT), a clinical-stage biopharmaceutical company developing novel, immune modulating cancer vaccines based on its T-win® technology platform, today announced three poster presentations at the Society for Immunotherapy of Cancer's 38th Annual Meeting (SITC) being held in San Diego, California from November 1-5, 2023.
"The data presented provide clear evidence that our immune modulating vaccines, developed based on our T-win technology platform, impact several immune escape mechanisms as elegantly exemplified in abstract #1468," said Mai-Britt Zocca, PhD, President and Chief Executive Officer of IO Biotech. "The data in this poster demonstrate enhanced in vivo anti-tumor effect when IDO and PD-L1 vaccines are co-administered in these models, further supporting the clinical observations regarding our lead investigational therapeutic vaccine candidate, IO102-IO103, which targets IDO and PD-L1. Data from clinical trials of IO102-IO103 administered with a PD-1 inhibitor demonstrated enhanced anti-tumor activity in multiple tumor types, including metastatic melanoma, non-small cell lung cancer and squamous cell cancer of the head and neck."
Dr. Zocca continued, "Additionally, the arginase-1 data presented in abstract #1335 further demonstrate the potential of our T-Win® technology platform to generate additional vaccine candidates. Our T-Win technology vaccine candidates are designed to kill both tumor cells and immune suppressive cells in the TME, by stimulating activation of T cells against a particular target, such as arginase-1. Arginase-1 is expressed by multiple difficult-to-treat tumor types including colorectal and ovarian cancers."
Abstract Number 1468: Peptide vaccination against PD-L1 reduces tumor growth in preclinical models through stimulation of PD-L1-targeting T cells in the tumor microenvironment
Presenter: Marion Chapellier, PhD, Senior Scientist, IO Biotech