JSPR - Jasper Therapeutics to Present Data on Briquilimab in Mast Cell Driven Diseases at the EAACI Congress 2024 | Benzinga
REDWOOD CITY, Calif., May 30, 2024 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ:JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address mast cell driven diseases such as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU) and asthma, today announced presentations of data from its preclinical and healthy volunteer studies of briquilimab, as well as trial-in-progress presentations from its BEACON and SPOTLIGHT clinical studies, at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2024, taking place May 31 – June 3 in Valencia, Spain.
The two preclinical studies being presented at EAACI showed the potential of briquilimab in asthma and atopic dermatitis (AD), respectively. The asthma study demonstrated that a single dose of briquilimab can deplete mast cells in both inflamed and non-inflamed tissue as well as improve lung function in an allergen-induced asthma model. In the AD study, treatment with briquilimab led to a reduction of dermal mast cells and inflammatory leukocytes, indicating that mast cells play a critical role in the pathogenesis of AD and that briquilimab has the potential to reverse AD pathology by depleting those cells. Both preclinical studies utilized Jasper's proprietary c-Kit Mouse™, which overcomes the limitations of standard models that do not bind antibodies directed at the human c-Kit receptor.
Jasper is also presenting data from the previously disclosed clinical study of briquilimab in healthy volunteers showing that it has a promising safety profile, appears to be well-tolerated, exhibits a favorable pharmacokinetic (PK) profile, and leads to sustained and dose-dependent depletion of mast cells in a cutaneous wound model. The PK and pharmacodynamic (PD) profiles demonstrated in the study support dose selection for Jasper's ongoing BEACON and SPOTLIGHT clinical trials in CSU and CIndU, the designs of which are being separately presented as well.
"Following the announcement our development program in asthma, we are pleased to present promising preclinical results demonstrating that briquilimab depletes peribronchial mast cells in an allergen-induced asthma model," said Wendy Pang, M.D., Ph.D., Senior Vice President, Research and Translational Medicine of Jasper. "While we decided to first pursue development in asthma, we are also excited about briquilimab in AD based in part on the results being presented at EAACI, which provide early evidence of the ability of briquilimab to reverse the disease pathology by depleting mast cells in the skin and reducing inflammatory leukocytes."
"As we execute our Phase 1b/2a BEACON and SPOTLIGHT trials in CSU and CIndU, we continue to explore briquilimab's broader potential in several mast cell diseases," said Edwin Tucker, Chief Medical Officer of Jasper. "We look forward to continuing to advance briquilimab in additional indications beyond urticaria, beginning with the planned commencement of patient enrollment in a Phase 1b/2a challenge study in asthma in the fourth quarter of 2024."
The details of the presentations are below:
Title: The BEACON Study: A Phase 1b/2a, Dose Escalation Study of Safety, Pharmacokinetic/Pharmacodynamic and Preliminary Clinical Activity of the c-Kit Mab Briquilimab in Adults with symptomatic Chronic Spontaneous Urticaria ...