MOLN - Molecular Partners Provides Updates at 42nd Annual J.P. Morgan Healthcare Conference | Benzinga

• Tetra-specific T-cell engager MP0533 for patients with r/r AML and AML/MDS on track to deliver expanded clinical phase 1/2a data in H1 2024
  
• Progress of Radio-DARPin Therapy (RDT) platform: Improved tumor to kidney uptake ratio enables expansion of RDT pipeline; first data on DLL3 as lead candidate; to be co-developed as ²¹²Pb-based RDT in new partnership with Orano Med
• Introduction of first program from the Switch-DARPin platform: the cKIT x CD16a x CD47 Switch-DARPin allows local conditional immune cell activation for targeted killing of hematopoietic stem cells (HSC) as next-generation conditioning for hematopoietic stem cell transplantation (HSCT) in AML and beyond.
  

ZURICH-SCHLIEREN, Switzerland and CONCORD, Mass., Jan. 07, 2024 (GLOBE NEWSWIRE) -- Ad hoc announcement pursuant to Art. 53 LR Molecular Partners AG ((SIX: MOLN, NASDAQ:MOLN), a clinical-stage biotech company developing a new class of custom-built protein drugs known as DARPin therapeutics, today announced it will present a business overview and provide its 2024 outlook at the 42^nd Annual J.P. Morgan Healthcare Conference.

Key current program status updates include:

MP0533 (CD33 x CD123 x CD70 x CD3)

• The Phase 1/2a trial of MP0533 continues to enroll patients with relapsed/refractory (r/r) acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS/AML). Enrolment of patients in dosing cohort 5 is complete, and enrolment in cohort 6, projected as a therapeutically active dose, is now ongoing.
• Positive initial data from the first four dosing cohorts indicate acceptable safety and encouraging initial antitumor activity with two responders reported across dosing cohorts 3 and 4. Data were presented at the 65^th American Society of Hematology (ASH) Annual Meeting and Exposition in December 2023.

Radio-DARPin Therapy (platform, DLL3)

• The Company has entered a strategic collaboration with Orano Med, a leader in targeted alpha therapies, to co-develop ²¹²Pb-based Radio-DARPin Therapies (RDT) for patients with solid tumors. Molecular Partners' previously disclosed DLL3 program will be the first included in the collaboration. The deal combines the power of DARPins, as a highly differentiated modality for tumor-targeted delivery of radioisotopes, with Orano Med's leading capabilities in alpha emitter technology and supply to further advance the RDT platform and expand Molecular Partner's RDT portfolio.
• Successful progress and optimization of Molecular Partners' RDT platform enables expansion of the RDT pipeline. Both reduction of kidney absorption (Stealth-DARPins) and enhanced tumor uptake via half-life engineering were achieved with DARPins for several targets, including DLL3.
• Molecular Partners continues to progress its RDT platform and portfolio of projects, both in-house and in partnership with Novartis.
  

Introduction of the first Switch-DARPin (cKIT x CD16a x CD47)

• The multispecific cKIT x CD16a x CD47 Switch-DARPin is the first program of the company's Switch-DARPin platform for targeted and conditional immune cell activation, designed as next-generation conditioning regimen for HSCT in AML and beyond.
  

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