BYSI - SEED Therapeutics Discloses Novel Molecular Glue IND Candidate for Cancer at Targeted Protein Degradation Think Tank Symposium | Benzinga
NEW YORK, Oct. 26, 2023 (GLOBE NEWSWIRE) -- SEED Therapeutics Inc. ("SEED"), a biotech company focused on harnessing and engineering Molecular Glues for targeted protein degradation (TPD) of disease-causing proteins, announced at its Monday, October 23, 2023 Targeted Protein Degradation (TPD) Think Tank symposium that it had successfully discovered a ST-00937, a new chemical entity (NCE) molecular glue that has already achieved IND Candidate status and will be advanced for the treatment of cancers in SEED's first IND filing, as early as 2024.
SEED is a subsidiary of BeyondSpring, Inc. (NASDAQ:BYSI), a clinical-stage biopharmaceutical company focusing on developing innovative therapies.
Dr. James Tonra, SEED President, and Chief Scientific Officer, said, "Preclinical data over the last two to three years has uncovered new and important cancer indications for agents that can inhibit or degrade the RNA splicing factor RBM39, but clinical activity in these new indications is minimal or absent."
According to Dr. Tonra, SEED's research and development scientists recognized this unmet need, as well as the opportunity to discover yet unrecognized additional indications for an RBM39 targeted molecular glue. "Our seasoned R&D team proceeded to discover and file a patent application for an oral RBM39 degrader that causes complete tumor regressions in select tumor models without detectable toxicities. SEED's rapid progress on this program towards clinical testing within a year of project initiation reflects the power and potential of TPD science, as well as SEED's expertise and determination to lead the way to patient benefits and the first regulatory approval with an RBM39 degrader."
The SEED TPD Think Tank was led by SEED Co-Founders who are ...