HOWL - Werewolf Therapeutics to Present Updated Data from Phase 1/1b Clinical Trial of WTX-124 as Monotherapy and in Combination with Pembrolizumab in Solid Tumors at 2024 ASCO Annual Meeting | Benzinga
- Updated single agent dose escalation data continues to demonstrate that WTX-124 is well tolerated and clinically active in patients with checkpoint inhibitor therapy relapsed/refractory cancers -
- Preliminary data on WTX-124 administered in combination with pembrolizumab show similar tolerability to WTX-124 monotherapy -
- Additional details and data post abstract cut-off date to be presented at ASCO -
- Company to host webcast to review these data on Monday, June 3, 2024, at 8:00 am ET -
WATERTOWN, Mass., May 23, 2024 (GLOBE NEWSWIRE) -- Werewolf Therapeutics, Inc. (the "Company" or "Werewolf") (NASDAQ:HOWL), an innovative biopharmaceutical company pioneering the development of conditionally activated therapeutics engineered to stimulate the body's immune system for the treatment of cancer, today announced the upcoming presentation of clinical data from dose-escalation arms of the Phase 1/1b trial evaluating WTX-124, its conditionally activated Interleukin-2 (IL-2) INDUKINE™ molecule, as monotherapy and in combination with pembrolizumab in patients with locally advanced or metastatic solid tumors after checkpoint inhibitor therapy. Highlights from the data as of January 28, 2024, were published today in an abstract for the upcoming poster presentation, which will include additional data from a May 1, 2024, cut-off date, at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 31 - June 4 in Chicago, Illinois.
"We are very pleased by WTX-124 clinical results published in today's abstract, which not only build upon initial monotherapy tolerability, biomarker and clinical activity data presented last Fall at SITC but also establish a similarly well-tolerated profile in combination with pembrolizumab," said Daniel J. Hicklin, Ph.D., President and Chief Executive Officer of Werewolf. "We believe the emerging profile from our IL-2 INDUKINE molecule has an opportunity to address the profound unmet medical need among patients with difficult-to-treat solid tumors who have progressed on checkpoint therapy and look forward to presenting additional details from monotherapy and combination therapy dose escalation arms of the trial at ASCO in early June."
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