DNLI - Biogen Denali to halt late-stage trial for Parkinson's disease drug

2023-06-05 10:26:34 ET

Denali Therapeutics ( NASDAQ: DNLI ) announced Monday that the company and its partner Biogen ( BIIB ) have decided to discontinue a Phase 3 trial for Parkinson’s disease (PD) candidate BIIB122 (DNL151).

The company said the decision follows a review of its portfolio timelines and existing resources. In a regulatory filing, Denali ( DNLI ) emphasized that the changes are not based on any safety or efficacy concerns related to BIIB122.

In line with a collaboration, Denali ( DNLI ) and Biogen ( BIIB ) were advancing BIIB122 in two global late-stage clinical trials: Phase 2b LUMA study targeted at early-stage PD and Phase 3 LIGHTHOUSE study for PD-related to LRRK2 mutations.

The companies said that patients already enrolled in the LIGHTHOUSE trial could enroll in the LUMA study, which, as part of the review, has also been modified to include PD patients with LRRK2 mutations.

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