AUPH - Calcineurin Inhibitor For Lupus Nephritis? Pull Your Trigger Carefully On Aurinia Pharmaceuticals
Lupus nephritis ((LN)) is an inflammation of the kidney caused by an autoimmune disease called systemic lupus erythematosus (SLE) which affects mostly women. It is classified by different disease progression stages, and the symptoms are usually quite systemic, including fever, proteinuria, edema, high blood pressure, etc. A significant percentage of patients eventually move to end-stage renal disease (ESRD). SLE patients with ESRD have an average increased risk of premature death (measured by standardized mortality ratio, or SMR) of 60 times than normal individuals, compared to SMR of 8 times for all SLE patients with renal