KPTI - Karyopharm: Why Is It Down And What Should Take It Back Up June, 23 2021 01:56 PM Karyopharm Therapeutics Inc. I list 8 potential reasons the stock is down despite approvals. SIENDO is a major binary event for the stock. The company has adequate cash. For further details see: Karyopharm: Why Is It Down, And What Should Take It Back Up