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home / news releases / GUD:CC - Knight Therapeutics Reports Fourth Quarter and Year-End 2022 Results


GUD:CC - Knight Therapeutics Reports Fourth Quarter and Year-End 2022 Results

MONTREAL, March 23, 2023 (GLOBE NEWSWIRE) -- Knight Therapeutics Inc. (TSX: GUD) ("Knight" or “the Company”), a leading Pan-American (ex-US) specialty pharmaceutical company, today reported financial results for its fourth quarter and year ended December 31, 2022. All currency amounts are in thousands except for share and per share amounts. All currencies are Canadian unless otherwise specified.

Financial information as at and for the year ended December 31, 2022 is unaudited.

2022 Highlights

Financials

  • Revenues were $293,563, an increase of $50,085 or 21% over prior year.
  • Gross margin of $138,061 or 47% of revenues compared to $115,412 or 47% of revenues in prior year.
  • Adjusted EBITDA 1 was $54,032, an increase of $16,027 or 42% over prior year.
  • Net loss on financial assets measured at fair value through profit or loss of $20,677.
  • Net loss was $29,892, compared to net income of $15,675 in prior year.
  • Cash inflow from operations was $40,481, compared to a cash inflow from operations of $44,618 in prior year.

Corporate Developments

  • Entered into a five-year secured loan of $52,416 (US$38,500) loan denominated in select LATAM currencies with International Finance Corporation (“IFC”).
  • Executed a settlement agreement with former controlling shareholders of GBT and received $6,030 (US$4,600).
  • Launched a NCIB in July 2022 to purchase up to 7,988,986 common shares of the Company over the next 12 months.
  • Purchased 5,649,189 common shares through Knight’s through Normal Course Issuer Bid (“NCIB”) at an average price of $5.34 for an aggregate cash consideration of $30,069.
  • Shareholders re-elected Jonathan Ross Goodman, Samira Sakhia, James C. Gale, Robert N. Lande, Michael J. Tremblay, Nicolás Sujoy and Janice Murray on the Board of Directors.
  • Hired Leopoldo Bosano as VP Manufacturing and Operations.

Products

  • Launched Lenvima ® , Halaven ® and Rembre ® in Colombia in Q1-22.
  • Entered into exclusive license and supply agreements with Rigel Pharmaceuticals to commercialize fostamatinib in LATAM in May 2022.
  • Entered into an exclusive license, distribution and supply agreement with Helsinn for AKYNZEO ® oral/IV (netupitant/palonosetron/fosnetupitant/palonosetron) in Canada, Brazil and select LATAM countries and ALOXI ® oral/IV (palonosetron) in Canada in May 2022.
  • Relaunched AKYNZEO ® in Canada, Brazil and Argentina, and ALOXI ® oral/IV in Canada in second half of 2022.
  • Transferred marketing authorization of Exelon ® (rivastigmine) and assumed commercial activities in Brazil, Colombia, Argentina, Mexico, Chile, Peru, Ecuador, Canada and re-launched Exelon ® in Brazil and certain other LATAM countries.
  • Submitted tafasitamab in combination with lenalidomide for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for autologous stem cell transplantation (ASCT) to ANVISA for regulatory approval in Brazil and Colombia in Q4-22 and Argentina in Q1-23.
  • In-license three branded generics products for key territories in LATAM.
  • Obtained regulatory approval for Palbocil ® (palbociclib) in Argentina in Q4-22.
  • Submitted two branded generic products (palbociclib and pomalidomide) for regulatory approval in Chile and Colombia in Q4-2022.

Subsequent Event

  • Purchased an additional 1,279,900 common shares through NCIB for an aggregate cash consideration of $6,577.

_______________________

1 Adjusted EBITDA is a non-GAPP measure, refer to the definitions below in section “Non-Gaap measures” for additional details

“I am excited to announce that we delivered another record year in 2022, with revenues of over $290,000, an increase of 21% over last year and record adjusted EBITDA of over $54,000, an increase of 42% over last year. This growth was generated by the full year effect of Exelon ® and the continued performance of our recent launches, including Lenvima ® , Halaven ® and Rembre ® in Colombia. While delivering on record results, we have completed the transfer of the commercial activities to Knight for Exelon ® and Akynzeo ® in our key markets. We continued to advance our pipeline with the regulatory submission of tafasitamab in Brazil, Colombia and Argentina as well as two branded generic products in Chile and Colombia. In addition, to the in-licensing of Akynzeo ® , we have expanded our pipeline portfolio in our key Latin America markets with fostamatinib and three branded generic products,” said Samira Sakhia, President and Chief Executive Officer of Knight Therapeutics Inc.


SELECT FINANCIAL RESULTS REPORTED UNDER IFRS
[In thousands of Canadian dollars]

[Unaudited]

Change
Change
Q4-22
Q4-21
$ 1
% 2
YTD-22
YTD-21
$ 1
% 2
Revenues
81,655
58,273
23,382
40
%
293,563
243,478
50,085
21
%
Gross margin
36,888
28,195
8,693
31
%
138,061
115,412
22,649
20
%
Operating expenses 4
67,938
42,829
(25,109
)
59
%
179,105
128,244
(50,861
)
40
%
Net (loss) income
(15,188
)
(8,301
)
(6,887
)
83
%
(29,892
)
15,675
N/A
N/A
EBITDA 3
13,330
4,101
9,229
225
%
53,541
35,865
17,676
49
%
Adjusted EBITDA 3
13,821
5,696
8,125
143
%
54,032
38,005
16,027
42
%

1 A positive variance represents a positive impact to net income (loss) and a negative variance represents a negative impact to net income (loss)
2 Percentage change is presented in absolute values
3 EBITDA and adjusted EBITDA are non-GAAP measures, refer to the definitions in section “Non-Gaap measures” for additional details
4 Operating expenses include selling and marketing expenses, general and administrative  expenses, research and development expenses, amortization and impairment of non current assets

SELECT FINANCIAL RESULTS AT CONSTANT CURRENCY
[In thousands of Canadian dollars]

[Unaudited]

Q4-22
Q4-21
Variance
YTD-22
YTD-21
Variance
Excluding impact of IAS 29 3
Constant Currency 3
$ 1
% 2
Constant Currency 3
$ 1
% 2
Revenues
83,806
58,370
25,436
44
%
291,770
243,731
48,039
20
%
Gross margin
41,931
29,692
12,239
41
%
150,359
120,694
29,665
25
%
Operating expenses 4
46,173
42,509
(3,664
)
9
%
151,158
124,865
(26,293
)
21
%
EBITDA 3
13,330
4,258
9,072
213
%
53,541
36,376
17,165
47
%
Adjusted EBITDA 3
13,821
5,884
7,937
135
%
54,032
38,551
15,481
40
%

1 A positive variance represents a positive impact to adjusted EBITDA and a negative variance represents a negative impact to adjusted EBITDA
2 Percentage change is presented in absolute values
3 Financial results at constant currency and excluding impact of IAS 29, EBITDA and adjusted EBITDA are non GAAP measures, refer to the specific sections for additional details
4 Operating expenses include selling and marketing expenses, general and administrative expenses, research  and development expenses, amortization and impairment of non-current assets

SELECT BALANCE SHEET ITEMS
[In thousands of Canadian dollars]

[Unaudited]

Change
12-31-22
12-31-21
$
% 1
Cash, cash equivalents and marketable securities
172,674
149,502
23,172
15
%
Trade and other receivables
151,669
103,875
47,794
46
%
Inventory
92,489
72,397
20,092
28
%
Financial assets
176,563
192,443
(15,880
)
8
%
Accounts payable and accrued liabilities
108,730
65,590
43,140
66
%
Bank loans
70,072
35,927
34,145
95
%

1 Percentage change is presented in absolute values

Revenues: For the quarter ended December 31, 2022, excluding the impact of hyperinflation, revenues increased by $27,448 or 49% compared to the same period in prior year. The increase in revenues excluding the impact of hyperinflation is explained by the following:

Excluding impact of IAS 29 3
Q4-22
Q4-21
Change
Therapeutic Area
$
$
$ 1
% 2
Oncology/Hematology
29,343
23,534
5,809
25
%
Infectious Diseases
32,744
20,211
12,533
62
%
Other Specialty
21,760
12,613
9,147
73
%
Total
83,806
56,358
27,448
49
%

1 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative impact to net income due to the application of IAS 29
2 Percentage change is presented in absolute values
3 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.

  • Oncology/hematology : The increase in revenues of $5,809 is driven by growth in our key promoted brands, including new launches of Lenvima® and Halaven® in Colombia in Q1-22, the growth of key promoted products including Lenvima® and Trelstar® and the assumption of commercial activities of Akynzeo® in Brazil and Canada. This increase is offset by a reduction in revenues of our branded generics products due to their lifecycle including the market entrance of new competitors.
  • Infectious disease: The portfolio grew by approximately $15,900, excluding the impact of the planned transition and termination of the Gilead Amendment. This growth is due to an increase in patient treatments as our markets reduce COVID-19 restrictions, growth of our key promoted products and a one-time sales contract with the Ministry of Health in Brazil for Ambisome® (“MOH Contract”). Knight recorded $7,500 in revenues, which represents 40% of the expected deliveries under the MOH contract in Q4-22 and the balance of the contract is expected to be delivered in the first six months of 2023
  • Other specialty : The growth is mainly due to the incremental revenue of $5,092 due to the change in accounting treatment of Exelon® from net profit transfer from Novartis to revenues with related cost of sales upon the transition of commercial activities to Knight as well as the timing of purchases of products by certain customers.

For the year ended December 31, 2022, excluding the impact of hyperinflation, revenues increased by $52,532 or 22% compared to the same period in prior year. The growth in revenues excluding the impact of hyperinflation is explained by the following:

Excluding impact of IAS 29 3
YTD-22
YTD-21
Change
Therapeutic Area
$
$
$ 1
% 2
Oncology/Hematology
105,464
89,079
16,385
18
%
Infectious Diseases
116,530
101,650
14,880
15
%
Other Specialty
69,776
48,509
21,267
44
%
Total
291,770
239,238
52,532
22
%

1 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative impact to net income due to the application of IAS 29
2 Percentage change is presented in absolute values
3 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details

  • Oncology/hematology : The increase in revenues of $15,960 is driven by growth in our key promoted brands, including the launches of Lenvima ® and Halaven ® in Colombia in Q1-22, the continued growth of key promoted products including Lenvima ® , Halaven ® and Trelstar ® and the assumption of commercial activities of Akynzeo ® in Brazil and Canada. This increase is offset by a reduction in revenues of our branded generics products due to their lifecycle including the market entrance of new competitors.
  • Infectious disease : The portfolio grew by approximately $29,080 due to increase in patient treatments as our markets reduce COVID-19 restrictions, growth of our key promoted products and a one-time sales contract with the Ministry of Health in Brazil for Ambisome ® (“MOH Contract”). Knight recorded $7,500 in revenues, which represents 40% of the expected deliveries under the MOH contract in Q4-22 and the balance of the contract is expected to be delivered in the first six months of 2023. The growth is offset by an estimated $14,200 due to lower demand for certain of our infectious diseases products to treat invasive fungal infections associated with COVID-19 as well as the planned transition and termination agreement of the Gilead Amendment effective July 1, 2022.
  • Other specialty : The increase is mainly driven by the timing of the acquisition of Exelon ® as well as a change in the accounting treatment of Exelon ® . The full year effect of the Exelon ® transaction executed on May 26, 2021, represents an incremental revenue of $15,282. The change in accounting treatment from net profit transfer from Novartis to recognition of revenues with related cost of sales upon transition of commercial activities to Knight led to an increase of $6,427 in revenues.

Gross margin: For the quarter ended December 31, 2022, gross margin as a percentage of revenues was 45% compared to 48% in the same prior year period. The decrease in the gross margin, as a percentage of revenues, is explained by the impact of hyperinflation. Excluding the impact of IAS 29, gross margin, as a percentage of revenues, was 50% in Q4-22 and 51% in Q4-21.

For the year ended December 31, 2022, there was no significant difference in gross margin, as a percentage of revenues, compared to the same prior year period. Excluding the impact of IAS 29, gross margin, as a percentage of revenues, was 52% for year ended December 31, 2022 compared to 50% in prior year. The increase in the gross margin is explained by the change in product mix including the full year effect of the acquisition of Exelon ® .

Selling and marketing: For the quarter ended December 31, 2022, S&M increased by $2,111 or 17%. Excluding the impact of IAS 29, the increase was $3,162 or 27% driven by an increase in compensation expenses including severance cost of $1,116 due to certain restructuring activities, an increase in selling and marketing activities related to key promoted products including spend on Exelon ® and Akynzeo ® as well as certain variable costs such as logistics fees due to higher sales.

For the year ended December 31, 2022, S&M increased by $9,396 or 24%. Excluding the impact of IAS 29, the increase is $9,827 or 26% mainly driven by an increase in compensation expenses including severances of $1,146, an increase in selling and marketing activities related to key promoted products including the spend on Exelon® and Akynzeo as well as certain variable costs such as logistics fees due to higher sales.

General and administrative: For the quarter ended on December 31, 2022, there was no significant variation in General and administrative expenses. For the year ended December 31, 2022, G&A increased by $4,852 or 14%. Excluding the impact of IAS 29, the increase is $3,721 or 11%, mainly driven by an increase in compensation expense certain consulting and professional fees offset by the lower costs related to the long-term incentive plan.

Research and development expenses : For the quarter ended on December 31, 2022, there was no significant variation in Research and development expenses. For the year ended December 31, 2022, R&D increased by $2,063 or 16%. Excluding the impact of IAS 29, the increase is $1,653 or 14%, mainly driven by an increase in compensation expenses and medical initiatives.

Amortization of intangible assets: For the year ended December 31, 2022, amortization of intangible assets increased by $10,566 or 26%, mainly explained by the amortization of $11,667 related to the full year effect of the acquisition of Exelon®.

Impairment of non-current assets : Under hyperinflation accounting, non-monetary assets including property plant and equipment, right-of-use assets and intangible assets are adjusted by the inflation index and converted back to Canadian Dollar (“CAD”) at the closing rate of the reporting period. During a period where the inflation index is higher than devaluation of the Argentine peso relative to the CAD, the value of the non-monetary assets increases when converted to CAD. During 2022, the increase in the value of non-monetary assets in Argentina due to hyperinflation accounting, resulted in an impairment of $21,654. The loss represents a write-down of certain right-of-use assets, property, plant and equipment in Argentina, and intangible assets related to branded generics intellectual property to its recoverable amount.

In addition, during 2022, the Company recorded an additional impairment loss of $2,330 representing the write-down of the upfront and certain milestones payments made under certain product license agreements as a result of changes in commercial expectations.
Interest income: Interest income is the sum of interest income on financial instruments measured at amortized cost and other interest income. For the quarter and year ended December 31, 2022, interest income was $4,263 and $10,632, an increase of 94% or $2,067 and 44% or $3,250 respectively, compared to the same period in prior year due to higher interest rates on cash and marketable securities as well as interest earned on strategic loans.

Interest expense: The increase for the quarter and year ended December 31, 2022, is due to the increase of the Certificados de Depositos Interfinancieros (Brazil interbank lending rate) (“CDI”) and Indicador Bancario de Referencia (Colombia interbank lending rate) (“IBR”) rates throughout 2022, partially offset by lower average loan balance due to partial repayment of Itaú Unibanco Brasil and Bancolombia bank loans.

In December 2022, the Company entered into a loan with IFC for an amount of $52,416 denominated in BRL, COP, CLP and MXN with interest rates ranging between 7.86% and 15.83% (“IFC Loan”). The interest expense on bank loans is expected to increase in 2023 due the IFC Loan as well as any future increases in variable interest rates.

Adjusted EBITDA: For the quarter ended December 31, 2022, adjusted EBITDA increased by $8,125 or 143%. The growth in adjusted EBITDA is driven by an increase in gross margin of $8,693, offset by an increase in operating expenses.

For the year ended December 31, 2022 adjusted EBITDA increased by $16,027 or 42%. The growth in adjusted EBITDA is driven by an increase in gross margin of $22,649 offset by an increase in operating expenses.

Net loss or income: For the quarter ended December 31, 2022, net loss was $15,188 compared to net loss of $8,301 for the same period last year. The increase in net loss mainly resulted from the above-mentioned items and (1) an increase in income tax recovery of $1,824 in the fourth quarter of 2022 due to the recognition of certain deferred tax assets as well as (2) a higher net gain on the revaluation of financial assets measured at fair value through profit or loss of $8,824 in the fourth quarter of 2022 versus a net gain of $2,300 in the prior year period mainly due to unrealized gains on revaluation of the strategic fund investments resulting from positive mark-to-market adjustments as a result of the increase in the share prices of one of the publicly-traded equities held by one of the funds, (3) foreign exchange loss of $1,633 versus a loss of $3,485 in the prior year period due to appreciation of the CAD versus the US dollar, and (4) a other expense for the quarter ended December 31, 2022 increase by $2,285 compared to the same period in prior year mainly due to the increase in a provision related to certain import tax claims.

For the year ended December 31, 2022, net loss was $29,892 compared to net income of $15,675 in prior year. The variance mainly resulted from the above-mentioned items and (1) an income tax recovery of $17,125 in 2022 due to the recognition of certain deferred tax assets due to timing differences related to our financial assets, impairment of certain non-current assets and certain intercompany transactions, compared to a prior year income tax recovery of $8,985, (2) a lower net loss on the revaluation of financial assets measured at fair value through profit or loss of $20,677 in 2022 versus a net gain of $18,944 in prior year mainly due to unrealized losses on revaluation of the strategic fund investments as a result of the decline in the share prices of the publicly-traded equities held by our strategic fund investments due to general market conditions, as well as (3) foreign exchange gain of $7,442 versus a loss of $3,737 in the prior year period due to appreciation of the US dollar compared to CAD in 2022, and (4) gain of $6,030 as a result of execution of settlement agreement and general release with the former shareholders of GBT, partially offset by expense due to the change in an accounting provision for a potential liability.

Cash, cash equivalents and marketable securities : As at December 31, 2022, Knight had $172,674 in cash, cash equivalents and marketable securities, including $18,961 [USD 14,000] pledged as restricted cash collateral under the IFC Loan. The increase of $23,172 or 15% as compared to December 31, 2022 primarily relates to cash generated through operating activities and funds received under the IFC Loan offset by cash outflows from shares purchased through the NCIB, the in-licensing of AKYNZEO ® and ALOXI ® from Helsinn as well as fostamatinib from Rigel, repayments on bank loans and foreign exchange gain on cash and cash equivalents.

Financial assets: As at December 31, 2022, financial assets were at $176,563, a decrease of $15,880 or 8%, as compared to the prior year, mainly due to a negative mark-to-market adjustments of $23,325 driven mostly by the decline in the share prices of the publicly-traded equities held by our strategic fund investments due to general market conditions, fund distributions of $6,478, decrease in equity investments and derivatives of $1,918 mainly due to disposal of Medimetriks offset by capital calls of $6,307, loans issued of $2,723 and foreign exchange gains of $6,245.

Bank Loans: As at December 31, 2022, bank loans were at $70,072, an increase of $34,145 or 95% as compared to the prior period, mainly due to the IFC loan offset by loan repayments.

Product Updates

Commercial Execution

In the first quarter of 2022, Knight launched three products in Colombia in Oncology/Hematology namely Lenvima® for differentiated thyroid cancer and unresectable hepatocellular carcinoma, Halaven ® for metastatic breast cancer and soft tissue sarcoma and Rembre ® , a branded generic product, for chronic myeloid leukemia.

As at March 22, 2023, the marketing authorizations of Exelon ® for Brazil, Colombia, Argentina, Mexico, Chile, Peru, Ecuador and Canada were transferred to Knight. In addition, Knight has assumed the commercial activities of Exelon ® in Colombia in Q2-22, Brazil, Argentina & Chile in Q3-22 and Mexico, Peru, Ecuador & Canada in Q4-22.

On May 12, 2022, Knight entered into an exclusive license, distribution and supply agreement with Helsinn for AKYNZEO ® oral/IV (netupitant/palonosetron / fosnetupitant/palonosetron) in Canada, Brazil and select LATAM countries and ALOXI ® oral/IV (palonosetron) in Canada. Knight has assumed commercial activities and re-launched AKYNZEO ® in Brazil and Argentina in July 2022 and in Canada in Q4-22.

On July 1, 2022, Knight has entered into a transition and termination agreement with Gilead for a portfolio of HIV and HCV products (“Gilead Amendment”). The portfolio is currently distributed by Knight in one or more of the following countries: Colombia, Peru, Ecuador, Bolivia and Paraguay. As part of the Gilead Amendment, Knight distributes the products under a mutually agreed amended commercial and financial terms, until the earlier of April 30, 2023 and the completion of the regulatory, logistical and commercial transition on a per country and product basis. The Gilead Amendment does not impact any products distributed by the Company on behalf of Gilead in Brazil.

Advancing our pipeline portfolio

Knight submitted tafasitamab (sold as Monjuvi ® in the United States and Minjuvi ® in Europe) in combination with lenalidomide for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are not eligible for autologous stem cell transplantation (ASCT) for regulatory approval to ANVISA in Brazil in October 2022, INVIMA in Colombia in December 2022 and ANMAT in Argentina in January 2023. Knight expects to submit tafasitamab in other key LATAM countries in the first half of 2023.

In December 2022, Knight obtained the regulatory approval for Palbocil ® (palbociclib) in Argentina. Knight launched Palbocil ® in Argentina in March 2023 and filed for regulatory approval for Bapocil ® (palbociclib) in Colombia and Chile in Q4-2022. Palbocil ® is indicated for the treatment of patients with hormone receptor (HR)positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine-based therapy in post-menopausal women or fulvestrant in patients with disease progression after prior endocrine therapy.

In addition, during the fourth quarter of 2022, Knight also submitted a branded generic of for regulatory approval in Chile and Colombia. Furthermore, the Company has in-licensed three branded generic products for our key markets in Latin America.

NCIB

On July 12, 2022, the Company announced that the Toronto Stock Exchange approved its notice of intention to launch a NCIB ("2022 NCIB"). Under the terms of the 2022 NCIB, Knight may purchase for cancellation up to 7,988,986 common shares of the Company which represented 10% of its public float as at June 30, 2022. The 2022 NCIB commenced on July 14, 2022 and will end on the earlier of July 13, 2023 or when the Company completes its maximum purchases under the NCIB. Furthermore, Knight entered into an agreement with a broker to facilitate purchases of its common shares under the NCIB. Under Knight's automatic share purchase plan, the broker may purchase common shares which would ordinarily not be permitted due to regulatory restrictions or self-imposed blackout periods.

For the year ended December 31, 2022, the Company purchased 5,649,189 (2021: 12,321,864) common shares at an average price of $5.34 (2021: $5.23) for aggregate cash consideration of $30,069 (2021: $64,415). Subsequent to December 31, 2022, the Company purchased an additional 1,279,900 common shares at an average purchase price of $5.14 for an aggregate cash consideration of $6,577.

Financial Outlook

Knight provides guidance on revenues 1 on a non-GAAP basis. This is due to both the difficulty in predicting Argentinian inflation rates and its IAS 29 impact.

For fiscal 2023, Knight expects to report $280 to $300 million in revenue and adjusted EBITDA, as a percentage of revenues, between 13% to 15% of revenue. The guidance is based on a number of assumptions, including but not limited to the following:

  • no revenues for business development transactions not completed as of March 22, 2023
  • discontinuation of certain distribution agreements
  • no interruptions in supply whether due to global supply chain disruptions or general manufacturing issues
  • no new generic entrants on our key pharmaceutical brands
  • no unforeseen changes to government mandated pricing regulations
  • successful commercial execution on product listing arrangements with HMOs, insurers, key accounts, and public payers
  • successful execution and uptake of newly launched products
  • no significant restrictions or economic shut down due to the COVID-19 pandemic
  • foreign currency exchange rates remaining within forecasted ranges

Should any of the assumptions differ, the financial outlook and the actual results may vary materially. Refer to the risks and assumptions referred to in the Forward-Looking Statements section of this news release for further details.

“Our team has been successfully executing on our pan-American ex US strategy and has built a profitable business with a unique platform and a strong foundation from where to continue growing over the long term.  We ended 2022 by delivering record revenues and adjusted EBITDA as a result of growing the current portfolio as well as adding new products that leverage our existing infrastructure. Looking ahead, while we will face headwinds with the entrance of new competitors on certain of our banded generic products as well as incur investments related to promoted products, Knight is expected to continue to generate strong cash flows from operations and with over $150,000 of cash and $175,000 of financial assets, we remain well positioned to execute on our mission to acquire, in-license, develop and commercialize pharmaceutical products in Latin America and Canada.” said Jonathan Ross Goodman, Executive Chairman of Knight Therapeutics Inc.

__________________________

1 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to the definitions in section “Non-Gaap measures” for additional details

Conference Call Notice

Knight will host a conference call and audio webcast to discuss its fourth quarter and year-end results today at 8:30 am ET. Knight cordially invites all interested parties to participate in this call.

Date: Thursday, March 23, 2023
Time: 8:30 a.m. ET
Telephone : Toll Free: 1-888-256-1007 or International 1-647-484-0475
Webcast: www.gud-knight.com or Webcast
This is a listen-only audio webcast. Media Player is required to listen to the broadcast.

Replay: An archived replay will be available for 30 days at www.gud-knight.com

About Knight Therapeutics Inc.

Knight Therapeutics Inc., headquartered in Montreal, Canada, is a specialty pharmaceutical company focused on acquiring or in-licensing and commercializing pharmaceutical products for Canada and Latin America. Knight’s Latin American subsidiaries operate under United Medical, Biotoscana Farma and Laboratorio LKM. Knight Therapeutics Inc.'s shares trade on TSX under the symbol GUD. For more information about Knight Therapeutics Inc., please visit the company's web site at www.gud-knight.com or www.sedar.com .

Forward-Looking Statement

This document contains forward-looking statements for Knight Therapeutics Inc. and its subsidiaries. These forward-looking statements, by their nature, necessarily involve risks and uncertainties that could cause actual results to differ materially from those contemplated by the forward-looking statements. Knight Therapeutics Inc. considers the assumptions on which these forward-looking statements are based to be reasonable at the time they were prepared but cautions the reader that these assumptions regarding future events, many of which are beyond the control of Knight Therapeutics Inc. and its subsidiaries, may ultimately prove to be incorrect. Factors and risks, which could cause actual results to differ materially from current expectations are discussed in Knight Therapeutics Inc.'s Annual Report and in Knight Therapeutics Inc.'s Annual Information Form for the year ended December 31, 2021 as filed on www.sedar.com . Knight Therapeutics Inc. disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information or future events, except as required by law.

CONTACT INFORMATION:

Investor Contact:
Knight Therapeutics Inc.
Samira Sakhia
Arvind Utchanah
President & Chief Executive Officer
Chief Financial Officer
T: 514.484.4483
T. +598.2626.2344
F: 514.481.4116
Email: info@knighttx.com
Email: info@knighttx.com
Website: www.gud-knight.com
Website: www.gud-knight.com


Financial Results

Impact of Hyperinflation

The Company applies IAS 29, Financial Reporting in Hyperinflation Economies, as the Company’s Argentine subsidiaries use the Argentine Peso as their functional currency. IAS 29 requires that the financial statements of an entity whose functional currency is the currency of a hyperinflationary economy be adjusted based on an appropriate general price index to express the effects of inflation. After applying for the effects of translation, the statement of income is converted using the closing foreign exchange rate of the month. The Company restated the revenues and operating expenses of each of the following months in the year ended December 31 using the following general price indexes:

[Unaudited]

January
February
March
April
May
June
July
August
September
October
November
December
2022
1.88
1.79
1.68
1.58
1.51
1.43
1.33
1.25
1.17
1.10
1.05
1.00
2021
1.45
1.40
1.34
1.28
1.24
1.20
1.17
1.14
1.10
1.06
1.04
1.00

If the Company did not apply IAS 29, the effect on the Company’s operating (loss) income would be as follows:

[Unaudited]

Q4-22
YTD-22
Reported under
IFRS

Excluding impact of
IAS 29
1
Variance
Reported under
IFRS

Excluding impact of
IAS 29
1
Variance
$ 2
% 3
$ 2
% 3
Revenues
81,655
83,806
(2,151
)
3
%
293,563
291,770
1,793
1
%
Cost of goods sold
44,767
41,875
(2,892
)
7
%
155,502
141,411
(14,091
)
10
%
Gross margin
36,888
41,931
(5,043
)
12
%
138,061
150,359
(12,298
)
8
%
Gross margin (%)
45
%
50
%
47
%
52
%
Expenses
Selling and marketing
14,402
15,073
671
4
%
48,474
48,083
(391
)
1
%
General and administrative
10,336
10,083
(253
)
3
%
40,150
37,451
(2,699
)
7
%
Research and development
4,140
4,043
(97
)
2
%
14,755
13,733
(1,022
)
7
%
Amortization of intangible assets
17,156
16,724
(432
)
3
%
51,742
49,561
(2,181
)
4
%
Impairment of non-current assets
21,904
250
(21,654
)
n/a 4
23,984
2,330
(21,654
)
n/a 4
Operating loss
(31,050
)
(4,242
)
(26,808
)
n/a 4
(41,044
)
(799
)
(40,245
)
n/a 4

1 Financial results excluding the impact of hyperinflation is a non-GAAP measure. Refer to section “Non-GAAP measures” for additional details.
2 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative impact to net income due to the application of IAS 29.
3 Percentage change is presented in absolute values.
4 Percentage change not relevant.

[Unaudited]

Q4-21
YTD-21
Reported under
IFRS

Excluding impact of
IAS 29
1
Variance
Reported under
IFRS

Excluding impact of
IAS 29
1
Variance
$ 2
% 3
$ 2
% 3
Revenues
58,273
56,358
1,915
3
%
243,478
239,238
4,240
2
%
Cost of goods sold
30,078
27,724
(2,354
)
8
%
128,066
120,409
(7,657
)
6
%
Gross margin
28,195
28,634
(439
)
2
%
115,412
118,829
(3,417
)
3
%
Gross margin (%)
48
%
51
%
47
%
50
%
Expenses
Selling and marketing
12,291
11,911
(380
)
4
%
39,078
38,256
(822
)
2
%
General and administrative
10,002
9,795
(207
)
2
%
35,298
33,730
(1,568
)
5
%
Research and development
3,496
3,087
(409
)
13
%
12,692
12,080
(612
)
5
%
Amortization of intangible assets
17,040
16,355
(685
)
4
%
41,176
38,824
(2,352
)
6
%
Operating loss
(14,634
)
(12,514
)
(2,120
)
17
%
(12,832
)
(4,061
)
(8,771
)
216
%

1 Financial results excluding the impact of hyperinflation is a non-GAAP measure. Refer to section “Non-GAAP measures” for additional details.
2 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative impact to net income due to the application of IAS 29.
3 Percentage change is presented in absolute values.

Impact of LATAM Foreign Exchange volatility

The Company records its transactions and balances in the respective functional currencies of its subsidiaries. Generally, for the LATAM subsidiaries, the functional currency is the local currency in the country where the entity operates. In order to convert a foreign-denominated transaction to the functional currency, the exchange rate prevailing at the date of the transaction is used. Furthermore, upon consolidation, for all subsidiaries with a functional currency other than CAD, the respective statements of income are translated using the average exchange rates for the period. The table below summarizes the average foreign exchange rates used for the conversion of selected LATAM currencies:

[Unaudited]

Rates
Q4-22
Q3-22
Q2-22
Q1-22
Q4-21
Q3-21
Q2-21
Q1-21
BRL
3.87
4.02
3.85
4.12
4.44
4.15
4.30
4.32
ARS
118.9
103.6
92.3
84.1
79.7
77.2
76.46
69.9
COP
3,550
3,363
3,074
3,093
3,080
3,058
3,012
2,812
CLP
674
712
660
639
656
614
583
572

The below table summarizes the variances quarter over quarter for selected LATAM currencies:

Variance (%) 1
Q4-22
Q3-22
Q2-22
Q1-22
Q4-21
Q3-21
Q2-21
Q1-21
BRL
4
%
-4
%
7
%
7
%
-7
%
3
%
0
%
-4
%
ARS
-15
%
-12
%
-10
%
-6
%
-3
%
-1
%
-9
%
-14
%
COP
-6
%
-9
%
1
%
0
%
-1
%
-2
%
-7
%
0
%
CLP
5
%
-8
%
-3
%
3
%
-7
%
-5
%
-2
%
2
%

1 Negative percentage represents a depreciation of the currency while a positive variance represents an appreciation of the currency.

Impact

Exchange rate fluctuations of LATAM currencies impact the Company’s results in two ways:

  1. Transactional impact: certain product purchases and operating expenses are denominated in foreign currencies (mainly USD, EURO and CHF); and,
  2. Translational impact: translation of local LATAM functional currency operating results to reporting currency in CAD.

Constant Currency

Financial results at constant currency 1 allow results to be viewed without the impact of fluctuations in foreign currency exchange rates thereby facilitating the comparison of results period over period. The presentation of financial results at constant currency is considered to be a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

Financial results at constant currency are obtained by translating the prior period results from the functional currencies to CAD using the conversion rates in effect during the current period. Furthermore, with respect to Argentina, the Company excludes the impact of hyperinflation and translates the results at the average exchange rate in effect for each of the periods.

______________________________

1 Financial results at constant currency are non-GAAP measure, refer to section “Non-GAAP measures” for additional details.

[Unaudited]

Q4-22
Q4-21
Variance
YTD-22
YTD-21
Variance
Excluding impact of IAS 29 1
Constant Currency 2
$ 3
% 4
Constant Currency 2
$ 3
% 4
Revenues
83,806
58,370
25,436
44
%
291,770
243,731
48,039
20
%
Cost of goods sold
41,875
28,678
(13,197
)
46
%
141,411
123,037
(18,374
)
15
%
Gross margin
41,931
29,692
12,239
41
%
150,359
120,694
29,665
25
%
Gross margin (%)
50
%
51
%
52
%
50
%
Expenses
Selling and marketing
15,073
12,223
(2,850
)
23
%
48,083
38,715
(9,368
)
24
%
General and administrative
10,083
10,289
206
2
%
37,451
34,458
(2,993
)
9
%
Research and development
4,043
3,193
(850
)
27
%
13,733
12,264
(1,469
)
12
%
Amortization of intangible assets
16,724
16,804
80
0
%
49,561
39,428
(10,133
)
26
%
Impairment of non-current assets
250
(250
)
100
%
2,330
(2,330
)
100
%
Operating (loss) income
(4,242
)
(12,817
)
8,575
67
%
(799
)
(4,171
)
3,372
81
%
EBITDA 5
13,330
4,258
9,072
213
%
53,541
36,376
17,165
47
%
Adjusted EBITDA 5
13,821
5,884
7,937
135
%
54,032
38,551
15,481
40
%

1 Financial results excluding the impact of hyperinflation is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.
2 Financial results at constant currency are non-GAAP measure, refer to section “Non-GAAP measures” for additional details.
3 A positive variance represents a positive impact to net income and a negative variance represents a negative impact to net income.
4 Percentage change is presented in absolute values.
5 Financial results at constant currency, EBITDA and adjusted EBITDA are non-GAAP measures, refer to section “Non-GAAP measures” and “Reconciliation to adjusted EBITDA” for additional details.

The financial results under IFRS reconcile to the financial results at constant currency as follows:

[Unaudited]

Q4-21
YTD-21
Reported under IFRS
IAS 29 Adjustment
Constant Currency Adjustment
Constant Currency 1
Reported under IFRS
IAS 29 Adjustment
Constant Currency Adjustment
Constant Currency 1
Revenues
58,273
(1,915
)
2,012
58,370
243,478
(4,240
)
4,493
243,731
Cost of goods sold
30,078
(2,354
)
954
28,678
128,066
(7,657
)
2,628
123,037
Gross margin
28,195
439
1,058
29,692
115,412
3,417
1,865
120,694
Expenses
Selling and marketing
12,291
(380
)
312
12,223
39,078
(822
)
459
38,715
General and administrative
10,002
(207
)
494
10,289
35,298
(1,568
)
728
34,458
Research and development
3,496
(409
)
106
3,193
12,692
(612
)
184
12,264
Amortization of intangible assets
17,040
(685
)
449
16,804
41,176
(2,352
)
604
39,428
Operating loss
(14,634
)
2,120
(303
)
(12,817
)
(12,832
)
8,771
(110
)
(4,171
)

1 F inancial results at constant currency are non- GAAP measure, refer to section “ Non-GAAP measures ” for additional details .


Consolidated Statement of (Loss) Income

[In thousands of Canadian dollars]

[Unaudited]

Change
Change
Q4-22
Q4-21
$ 1
% 2
YTD-22
YTD-21
$ 1
% 2
Revenues
81,655
58,273
23,382
40
%
293,563
243,478
50,085
21
%
Cost of goods sold
44,767
30,078
(14,689
)
49
%
155,502
128,066
(27,436
)
21
%
Gross margin
36,888
28,195
8,693
31
%
138,061
115,412
22,649
20
%
Gross margin (%)
45
%
48
%
47
%
47
%
Expenses
Selling and marketing
14,402
12,291
(2,111
)
17
%
48,474
39,078
(9,396
)
24
%
General and administrative
10,336
10,002
(334
)
3
%
40,150
35,298
(4,852
)
14
%
Research and development
4,140
3,496
(644
)
18
%
14,755
12,692
(2,063
)
16
%
Amortization of intangible assets
17,156
17,040
(116
)
1
%
51,742
41,176
(10,566
)
26
%
Impairment of non-current assets
21,904
(21,904
)
100
%
23,984
(23,984
)
100
%
Operating (loss) income
(31,050
)
(14,634
)
(16,416
)
112
%
(41,044
)
(12,832
)
(28,212
)
220
%
Interest income on financial instruments measured at amortized cost
(1,922
)
(725
)
1,197
165
%
(4,072
)
(2,446
)
1,626
66
%
Other interest income
(2,341
)
(1,471
)
870
59
%
(6,560
)
(4,936
)
1,624
33
%
Interest expense
2,293
1,331
(962
)
72
%
6,600
3,618
(2,982
)
82
%
Other (income) expense
1,964
(321
)
(2,285
)
712
%
(4,025
)
(128
)
3,897
3045
%
Net loss (gain) on financial assets measured at fair value through profit or loss
(8,824
)
(2,300
)
6,524
284
%
20,677
(18,944
)
(39,621
)
209
%
Foreign exchange (gain) loss
1,663
3,485
1,822
52
%
(7,442
)
3,737
11,179
299
%
Gain on hyperinflation
(748
)
(209
)
539
258
%
(2,262
)
(423
)
1,839
435
%
Income (loss) before income taxes
(23,135
)
(14,424
)
(8,711
)
60
%
(43,960
)
6,690
50,650
757
%
Income tax
Current
882
(2,642
)
(3,524
)
133
%
3,057
(1,349
)
(4,406
)
327
%
Deferred
(8,829
)
(3,481
)
5,348
154
%
(17,125
)
(7,636
)
9,489
124
%
Income tax recovery
(7,947
)
(6,123
)
1,824
30
%
(14,068
)
(8,985
)
5,083
57
%
Net (loss) income for the period
(15,188
)
(8,301
)
(6,887
)
83
%
(29,892
)
15,675
(45,567
)
291
%
Basic and diluted net (loss) earnings per share
(0.13
)
(0.07
)
(0.07
)
99
%
(0.26
)
0.13
(0.39
)
307
%
EBITDA 3
13,330
4,101
9,229
225
%
53,541
35,865
17,676
49
%
Adjusted EBITDA 3
13,821
5,696
8,125
143
%
54,032
38,005
16,027
42
%

1 A positive variance represents a positive impact to net income (loss) and a negative variance represents a negative impact to net income (loss).
2 Percentage change is presented in absolute values .
3 EBITDA and a djusted EBITDA is a non- GAAP measure, refer to section “Non- GAAP measures” and “Reconciliation to adjusted EBITDA” for additional details .


Revenues
Q4-22 vs Q4-21
Q4-22
Q4-21
Q4-21
Change
Excluding impact of IAS 29 3
Excluding impact of IAS 29 3
Constant Currency 4
Excluding impact of IAS 29 3

Therapeutic Area
$
$
$
$ 1
% 2
Oncology/Hematology
29,343
23,534
23,876
5,809
25
%
Infectious Diseases
32,744
20,211
21,393
12,533
62
%
Other Specialty
21,719
12,613
13,101
9,106
72
%
Total
83,806
56,358
58,370
27,448
49
%
1 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative
impact to net income due to the application of IAS 29
2 Percentage change is presented in absolute values
3 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.
4 Revenues at constant currency is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details
For the quarter ended December 31, 2022, excluding the impact of hyperinflation, revenues increased by $27,448 or 49% compared to the same period in prior year. The increase in revenues excluding the impact of hyperinflation is explained by the following:

  • Oncology/Hematology: The increase in revenues of $5,809 is driven by growth in our key promoted brands, including new launches of Lenvima ® and Halaven ® in Colombia in Q1-22, the growth of key promoted products including Lenvima ® and Trelstar ® and the assumption of commercial activities of Akynzeo ® in Brazil and Canada. This increase is offset by a reduction in revenues of our branded generics products due to their lifecycle including the market entrance of new competitors.

    Infectious Diseases: The infectious disease portfolio grew by approximately $15,900, excluding the impact of the planned transition and termination of the Gilead Amendment. This growth is due to an increase in patient treatments as our markets reduce COVID-19 restrictions, growth of our key promoted products and a one-time sales contract with the Ministry of Health in Brazil for Ambisome ® (“MOH Contract”). Knight recorded $7,500 in revenues, which represents 40% of the expected deliveries under the MOH contract in Q4-22 and the balance of the contract is expected to be delivered in the first six months of 2023.

    Other Specialty: The increase in revenues is mainly due to incremental revenue of $5,092 due to the change in accounting treatment of Exelon ® from net profit transfer from Novartis to revenues with related cost of sales upon the transition of commercial activities to Knight as well as the timing of purchases of products by certain customers.
All the pharmaceutical products sold by Knight are categorized as either innovative or BGx products. The description of each portfolio are as follows:

Innovative Portfolio : The portfolio consists of the pharmaceutical products with innovative molecules and includes both in-licensed products such as Lenvima ® , Cresemba ® , Halaven ® , Trelstar ® , Akynzeo ® , Ambisome ® as well as products owned (or partially owned) by Knight such as Exelon ® and Impavido ® . The categories of the portfolio are as follows:
  • Innovation – Promoted portfolio: consists of products on which the Company invest in commercial activities such as sales force promotion and products that require medical activities.
  • Innovative – Mature: consists of products that require lower level of promotional activities and/or products that have reached their peak market capture potential.
  • Innovative – Discontinued: consists of products that the company has stopped commercializing or is in the process of discontinuing sales.
BGx Portfolio : The portfolio consists of branded generic products which are pharmaceutically equivalent to an innovative molecule. The branded generics are given a brand name to differentiate the product from ordinary generics or other branded generics. The Company’s branded generic portfolio currently primarily consists of products manufactured at our facilities in Argentina for commercialization in Argentina and the rest of Latin America (excluding Brazil and Mexico). The categories of portfolio are as follows:

  • BGx New Launches: consists of branded generic pharmaceutical products in the first three years of launch.
  • BGx Mature: consists of products which have been launched for more than three years.
  • BGx – Discontinued: consists of products that the company has stopped commercializing or is in the process of discontinuing sales.
During the quarter ended December 31, 2022, excluding the impact of IAS 29 the Company generated $68,404 or 82% of total revenues from its innovative portfolio and $15,402 or 18% of total revenues from its BGx portfolio.


Q4-22
Q4-21
Change
Excluding impact of IAS 29 3
Excluding impact of IAS 29 3
Excluding impact of IAS 29 3

Product portfolio
$
$
$ 1
% 2
Innovative – Promoted
54,270
26,127
28,143
108
%
Innovative – Mature
13,399
9,199
4,200
46
%
Innovative – Discontinued
735
3,547
(2,812
)
79
%
Total Innovative
68,404
38,873
29,531
76
%
BGx - New Launches
2,999
2,730
269
10
%
BGx – Mature
11,661
12,814
(1,153
)
9
%
BGx – Discontinued
742
1,941
(1,199
)
62
%
Total BGx
15,402
17,485
(2,083
)
12
%
Total
83,806
56,358
27,448
49
%
1 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative
impact to net income due to the application of IAS 29
2 Percentage change is presented in absolute values
3 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.
4 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative
impact to net income due to the application of IAS 29


Change
Excluding impact of IAS 29 3

Product portfolio
$ 1
% 2
Innovative – Promoted
28,143
108
%
  • Incremental revenues of $5,092 related to the change in accounting treatment from net profit transfer to recognition of revenues and cost of sales of Exelon ®
  • Incremental revenues of $7,500 related to the Ambisome ® MOH Contract
  • Incremental revenues from launches of Lenvima ® and Halaven ® Colombia in Colombia in Q1-22
  • Continued growth of key promoted products including Lenvima ® , Cresemba ® and Trelstar ®
Innovative - Mature
4,200
46
%
  • Due to growth of Impavido® in certain markets and timing of sales of certain products
Innovative - Discontinued
(2,812
)
79
%
  • Due to planned transition and termination agreement of the Gilead Amendment effective July 1, 2022
Total Innovative
29,531
76
%
BGx - New Launches
269
10
%
  • Due to the launch of Rembre® in Colombia and Dolufevir® in Argentina
BGx - Mature
(1,153
)
9
%
  • Due to lifecycle of products including entrance of new competition
BGx - Discontinued
(1,199
)
62
%
  • Discontinuation of the products at the end of their lifecycle
Total BGx
(2,083
)
12
%
Total
27,448
49
%
1 Percentage change is presented in absolute values
2 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.


YTD-22 vs YTD-21
YTD-22
YTD-21
YTD-21
Change
Excluding impact of IAS 29 3
Excluding impact of IAS 29 3
Constant Currency 4
Excluding impact of IAS 29 3

Therapeutic Area
$
$
$
$ 1
% 2
Oncology/Hematology
105,464
89,079
89,505
16,385
18
%
Infectious Diseases
116,530
101,650
106,640
14,880
15
%
Other Specialty
69,776
48,509
47,586
21,267
44
%
Total
291,770
239,238
243,731
52,532
22
%
1 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative impact to net income due to the application of IAS 29
2 Percentage change is presented in absolute values
3 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.
4 Revenues at constant currency is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details
4 Revenues at constant currency is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details


For the twelve-month period ended December 31, 2022, excluding the impact of hyperinflation, revenues increased by $52,532 or 22% compared to the same period in prior year. The growth in revenues excluding the impact of hyperinflation is explained by the following:

  • Oncology/Hematology: The increase in revenues of $15,960 is driven by growth in our key promoted brands, including the launches of Lenvima ® and Halaven ® in Colombia in Q1-22, the continued growth of key promoted products including Lenvima ® , Halaven ® and Trelstar ® and the assumption of commercial activities of Akynzeo® in Brazil and Canada. This increase is offset by a reduction in revenues of our branded generics products due to their lifecycle including the market entrance of new competitors.

    Infectious Diseases: The infectious disease portfolio grew by approximately $29,080 due to increase in patient treatments as our markets reduce COVID-19 restrictions, growth of our key promoted products and a one-time sales contract with the Ministry of Health in Brazil for Ambisome ® (“MOH Contract”). An incremental revenue of $7,500 representing 40% of the expected deliveries under the MOH contract was recorded in Q4-22 and the balance of the contract is expected to be delivered in the first six months of 2023. The growth is offset by an estimated $14,200 due to lower demand for certain of our infectious diseases products to treat invasive fungal infections associated with COVID-19 as well as the planned transition and termination agreement of the Gilead Amendment effective July 1, 2022.
  • Other Specialty: The revenues increase is mainly driven by the timing of the acquisition of Exelon® as well as a change in the accounting treatment of Exelon®. The full year effect of the Exelon® transaction executed on May 26, 2021, represents an incremental revenue of $15,282. The change in accounting treatment from net profit transfer from Novartis to recognition of revenues with related cost of sales upon transition of commercial activities to Knight led to an increase of $6,427 in revenues.


During the year ended December 31, 2022, excluding the impact of IAS 29, the Company generated revenues of $228,003 or 78% of total revenues from its innovative portfolio and $63,767 or 22% of total revenues from its BGx portfolio.
YTD-22
YTD-21
Change
Excluding impact of IAS 29 3
Excluding impact of IAS 29 3
Excluding impact of IAS 29 3

Product portfolio
$
$
$ 1
% 2
Innovative - Promoted
170,391
120,127
50,264
42
%
Innovative - Mature
49,209
41,998
7,211
17
%
Innovative - Discontinued
8,403
13,389
(4,986
)
37
%
Total Innovative
228,003
175,514
52,489
30
%
BGx - New Launches
12,091
7,115
4,976
70
%
BGx - Mature
47,744
49,772
(2,028
)
4
%
BGx - Discontinued
3,932
6,837
(2,905
)
42
%
Total BGx
63,767
63,724
43
0

%

Total
291,770
239,238
52,532
22
%
1 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative impact to net income due to the A positive
variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative impact to net income due to the application of IAS 29
2 Percentage change is presented in absolute values
3 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.


Change
Excluding impact of IAS 29 3

Product portfolio
$ 1
% 2
Innovative - Promoted
50,264
42
%
  • Incremental revenues of $15,282 related to the full year effect of acquisition of Exelon® and $6,427 related to the change in accounting treatment from net profit transfer to recognition of revenues and cost of sales
  • Incremental revenues of $7,500 related to the Ambisome® MOH Contract
  • Incremental revenues from launches of Lenvima® and Halaven® Colombia in Colombia in Q1-21
  • Continued growth of key promoted products including Lenvima®, Cresemba® and Trelstar®
Innovative - Mature
7,211
17
%
  • Due to growth of Impavido® in certain markets and timing of sales of certain products
Innovative - Discontinued
(4,986
)
37
%
  • Due to planned transition and termination agreement of the Gilead Amendment effective July 1, 2022
Total Innovative
52,489
30
%
BGx - New Launches
4,976
70
%
  • Due to launch of Rembre® in Colombia in Q1-22 and continued growth of Dolufevir® in Argentina
BGx - Mature
(2,028
)
4
%
  • Due to lifecycle of products including entrance of new competition
BGx - Discontinued
(2,905
)
42
%
  • Discontinuation of the products at the end of their lifecycle
Total BGx
43
0
%
Total
52,532
22
%

1 A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative variance represents a negative
impact to net income due to the A positive variance represents a positive impact to net income due to the application of IAS 29 and a negative
variance represents a negative impact to net income due to the application of IAS 29
2 Percentage change is presented in absolute values
3 Revenues excluding the impact of IAS 29 is a non-GAAP measure, refer to section “Non-GAAP measures” for additional details.


Gross margin
Q4-22 vs Q4-21
  • Under IFRS, for the quarter ended December 31, 2022, gross margin, as a percentage of revenues, decreased from 48% in Q4-21 to 45% in Q4-22. The decrease in the gross margin, as a percentage of revenues, is explained by the impact of hyperinflation. Excluding the impact of IAS 29, gross margin, as a percentage of revenues, was 50% in Q4-22 and 51% in Q4-21.
YTD-22 vs YTD-21
  • For the year ended December 31, 2022, there was no significant difference in gross margin, as a percentage of revenues, compared to the same prior year period. Excluding the impact of IAS 29, gross margin, as a percentage of revenues, was 52% for year ended December 31, 2022 compared to 50% in prior year. The increase in the gross margin is explained by the change in product mix including the full year effect of the acquisition of Exelon®.
Selling and marketing
Q4-22 vs Q4-21
  • For the quarter ended December 31, 2022, S&M increased by $2,111 or 17%. Excluding the impact of IAS 29, the increase is $3,162 or 27% driven by an increase in compensation expenses including severance cost of $1,116 due to certain restructuring activities, an increase in selling and marketing activities related to key promoted products including spend on Exelon® and Akynzeo® as well as certain variable costs such as logistics fees due to higher sales.
YTD-22 vs YTD-21
  • For the twelve-month period ended December 31, 2022, S&M increased by $9,396 or 24%. Excluding the impact of IAS 29, the increase is $9,827 or 26% mainly driven by an increase in compensation expenses including severances of $1,146, an increase in selling and marketing activities related to key promoted products including the spend on Exelon® and Akynzeo as well as certain variable costs such as logistics fees due to higher sales.
General and administrative
Q4-22 vs Q4-21
  • No significant variance
YTD-22 vs YTD-21
  • For the twelve-month period ended December 31, 2022, G&A increased by $4,852 or 14%. Excluding the impact of IAS 29, the increase is $3,721 or 11%, mainly driven by an increase in compensation expense certain consulting and professional fees offset by the lower costs related to the long-term incentive plan.
Research and development expenses

Q4-22 vs Q4-21
  • No significant variance
YTD-22 vs YTD-21
  • For the twelve-month period ended December 31, 2022, R&D increased by $2,063 or 16%. Excluding the impact of IAS 29, the increase is $1,653 or 14%, mainly driven by an increase in compensation expenses and medical initiatives.
Amortization of intangible assets

YTD-22 vs YTD-21
  • For the year ended December 31, 2022, amortization of intangible assets increased by $10,566 or 26%, mainly explained by the amortization of $11,667 related to the full year effect of the acquisition of Exelon®.
Impairment of non-current assets

YTD-22 vs YTD-21 and Q4-22 vs Q4-21
  • Under hyperinflation accounting, non-monetary assets including property plant and equipment, right-of-use assets and intangible assets are adjusted by the inflation index and converted back to CAD at the closing rate of the reporting period. During a period where the inflation index is higher than devaluation of the Argentine peso relative to the CAD, the value of the non-monetary assets increases when converted to CAD.
  • During 2022, the increase in the value of non-monetary assets in Argentina due to hyperinflation accounting, resulted in an impairment of $21,654 (2021: Nil) of these assets which was recorded in “Impairment of non-current assets”. The loss represents a write-down of certain right-of-use assets, property, plant and equipment in Argentina, and intangible assets related to branded generics intellectual property to its recoverable amount.
  • In addition, during 2022, the Company recorded an additional impairment loss of $2,330 representing the write-down of the upfront and certain milestones payments made under certain product license agreements as a result of changes in commercial expectations.
I nterest income

YTD-22 vs YTD-21 and Q4-22 vs Q4-21
  • Includes “Interest income on financial instruments measured at amortized cost” and “Other interest income”.
  • Primarily from interest earned on loans, cash and cash equivalents, marketable securities and accretion on loans receivable.
  • Interest income for Q4-22 was $4,263 and YTD-22 $10,632, an increase of 94% or $2,067 and 44% or $3,250, respectively, compared to the same period in prior year due to higher interest rates on cash and marketable securities as well as interest earned on loans.
Interest Expense

Q4-22 vs Q4-21 and YTD-22 vs YTD-21
  • The interest expense for Q4-22 and YTD-22 includes the interest expense on bank loans of $1,363 and $5,089 and interest expense of lease liabilities and other of $1,511 and $930 respectively.
  • Interest expense on banks loans for the Q4-22 and YTD-22 increased by $407 or 43% and by $2,364 or by 87% respectively, compared to the same periods in prior year, due to the increase of the CDI and IBR rates throughout 2022, partially offset by lower average loan balance due to partial repayment of Itaú Unibanco Brasil and Bancolombia bank loans. Refer to Section Liquidity and Capital Resources for further information on the bank loans.
  • The Company entered into a loan with IFC for an amount of $52,416 [USD 38,500] denominated in BRL, COP, CLP and MXN with interest rates ranging between 7.86% and 15.83% as at December 31, 2022. The interest expense on bank loans is expected to increase in 2023 due to the IFC loan as well as any future increases in variable interest rates.
Other income (expense)

Q4-22 vs Q4-21
  • Other expense for the three-month period ended December 31, 2022 increased by $2,285 or by 712% compared to the same period in prior year mainly due to the increase in a provision related to certain import tax claims.
YTD-22 vs YTD-21
  • Other income for the year ended December 31, 2022 increased by $3,897 or 3045%. The Company recorded a gain of $6,030 (US$4,600) upon execution of a settlement agreement and general release with the former shareholders of GBT. The settlement gain was partially offset by the increase in a provision related to certain import tax claims.
Net gain or loss on financial assets measured at fair value through profit or loss

Q4-22 vs Q4-21
  • Net gain on financial assets measured at fair value through profit and loss for Q4-22 was $8,824, mainly driven by unrealized gain on revaluation of our strategic fund investments resulting from positive mark-to-market adjustments as a result of the increase in the share prices of one of the publicly-traded equities held by one of the funds.
YTD-22 vs YTD-21
  • Net loss on financial assets measured at fair value through profit and loss for YTD-22 was $20,677, mainly driven by negative mark-to-market adjustments as a result of the decline in the share prices of the publicly-traded equities held by our strategic fund investments due to general market conditions.


Foreign exchange gain or loss
Q4-22 vs Q4-21
  • The foreign exchange loss in the three months ended Q4-22 and Q4-21 is mainly driven by the unrealized losses on revaluation of our financial assets including our cash balances as well as unrealized loss on intercompany balances due to the appreciation of the CAD vs. the USD.
YTD-22 vs YTD-21

  • The foreign exchange gains in YTD-22 are mainly driven by the unrealized gains on revaluation of our financial assets including our cash balances as well as intercompany balances due to the appreciation of the USD and EURO vs. the CAD, partially offset by the depreciation of the select LATAM currencies throughout the year.
  • The foreign exchange loss in Q4-21 and YTD-21 is mainly driven by the unrealized losses on revaluation of our financial assets including our cash balances due to the appreciation of the CAD vs. the USD and EURO.
Gain or loss on hyperinflation
  • Relates to gain on net monetary position (monetary assets less monetary liabilities) under hyperinflation accounting. Refer to “Impact of Hyperinflation” section for further details.
Income tax expense
  • The income tax recovery for Q4-22 and YTD-22 is driven by the recognition of certain deferred tax assets due to timing differences related to our financial assets, impairment of certain non-current assets and certain intercompany transactions.
  • The income tax recovery for Q4-21 and YTD-21 is driven by the recognition of certain deferred tax assets due tax losses generated, timing differences related to certain intercompany transactions, financial assets and impairment of certain non-current assets.


Non-GAAP measures

The Company discloses non-GAAP measures that do not have standardized meanings prescribed by IFRS. The Company believes that shareholders, investment analysts and other readers find such measures helpful in understanding the Company’s financial performance. Non-GAAP financial measures do not have any standardized meaning prescribed by IFRS and may not have been calculated in the same way as similarly named financial measures presented by other companies.

The Company uses the following non-GAAP measures:

Revenues and Financial results excluding the impact of hyperinflation under IAS 29 : Revenues and financial results under IFRS are adjusted to remove the impact of hyperinflation under IAS 29. Impact of hyperinflation under IAS 29 is calculated by applying an appropriate general price index to express the effects of inflation. After applying the effects of translation, the statement of income is converted using the closing foreign exchange rate of the month.

Revenues and Financial results at constant currency : Revenues/financial results at constant currency are obtained by translating the prior period revenues/financial results from the functional currencies to CAD using the conversion rates in effect during the current period. Furthermore, with respect to Argentina, the Company excludes the impact of hyperinflation and translates the revenues/results at the average exchange rate in effect for each of the periods.

Revenues/financial results at constant currency allow revenues/financial results to be viewed without the impact of fluctuations in foreign currency exchange rates thereby facilitating the comparison of results period over period. The presentation of revenues/financial results under constant currency is considered to be a non-GAAP measure and does not have any standardized meaning under GAAP. As a result, the information presented may not be comparable to similar measures presented by other companies.

EBITDA: Operating income or loss adjusted to exclude amortization and impairment of long-lived assets, depreciation, purchase price allocation accounting adjustments, and the impact of IAS 29 (accounting under hyperinflation) but to include costs related to leases.

Adjusted EBITDA: EBITDA adjusted for acquisition costs and non-recurring expenses.

Reconciliation to adjusted EBITDA

For the three-month period and year ended December 31, 2022, the Company calculated EBITDA and adjusted EBITDA as follows:

[Unaudited]
Change
Change
Q4-22
Q4-21
$ 1
% 2
YTD-22
YTD-21
$ 1
% 2
Operating loss
(31,050
)
(14,634
(16,416
)
112
%
(41,044
)
(12,832
)
(28,212
)
220
%
Adjustments to operating loss:
Amortization of intangible assets
17,156
17,040
116
1
%
51,742
41,176
10,566
26
%
Impairment of non-current assets
21,904
21,904
100
%
23,984
23,984
100
%
Depreciation of property, plant and equipment and ROU assets
3,037
1,961
1,076
55
%
10,879
6,739
4,140
61
%
Lease costs (IFRS 16 adjustment)
(836
)
(874
38
4
%
(2,750
)
(3,016
)
266
9
%
Impact of IAS 29
3,119
608
2,511
413
%
10,730
3,798
6,932
183
%
EBITDA 3
13,330
4,101
9,229
225
%
53,541
35,865
17,676
49
%
Acquisition and transaction costs
0
%
432
(432
)
100
%
Other non-recurring expenses
491
1,595
(1,104
)
69
%
491
1,708
(1,217
)
71
%
Adjusted EBITDA 3
13,821
5,696
8,125
143
%
54,032
38,005
16,027
42
%

1 A positive variance represents a positive impact to EBITDA and adjusted EBITDA and a negative variance represents a negative impact to EBITDA and adjusted EBITDA
2 Percentage change is presented in absolute values
3 EBITDA and a djusted EBITDA are non- GAAP measure s , refer to section “ Non-GAAP measures ” for additional details


Explanation of adjustments

Acquisition costs
Acquisition and transaction costs relate to costs incurred on legal, consulting and advisory fees
for the acquisition of GBT and the acquisition of products.

During the year ended December 31, 2021 the Company incurred expenses of $432 related
to acquisition of Exelon® (Q4-21: Nil).

Other non-recurring expenses
Other non-recurring expenses relate to expenses incurred by the Company that are not due to,
and are not expected to occur in, the ordinary course of business.

For the year ended December 31, 2022, the Company incurred non-recurring costs of $491
(Q4-22: $491) related to restructuring activities including severance to certain employees as
part of restructuring and integration of GBT.

For the year ended December 31, 2021, the Company incurred non-recurring costs of $1,708
(Q4-21: $1,595) related to restructuring activities including severance to certain employees as
part of restructuring and integration of GBT.


Adjusted EBITDA Q4-22 vs Q4-21

For the three-month period ended December 31, 2022 adjusted EBITDA increased by $8,125 or 143%. The growth in adjusted EBITDA is driven by an increase in gross margin of $8,693 offset by an increase in operating expenses. Refer to above explanations for further details.

Adjusted EBITDA YTD-22 vs YTD-21

For the year ended December 31, 2022 adjusted EBITDA increased by $16,027 or 42%. The growth in adjusted EBITDA is driven by an increase in gross margin of $22,649 offset by an increase in operating expenses. Refer to above explanations for further details.


Financial Condition

Impact of LATAM Foreign Exchange volatility

The following table represents the quarter end closing rates used by Knight to convert the assets and liabilities on the balance sheet at the end of each reporting period.

Rates
Q4-22
Q3-22
Q2-22
Q1-22
Q4-21
BRL
3.90
3.94
4.05
3.80
4.40
ARS
130.53
107.12
97.07
88.72
80.88
COP
3,584
3,322
3,205
3,012
3,195
CLP
629
703
718
631
671


The below table summarizes the variances quarter over quarter for selected LATAM currencies:

Variance (%) 1
Q4-22
Q3-22
Q2-22
Q1-22
BRL
1
%
3
%
-7
%
14
%
ARS
-22
%
-10
%
-9
%
-10
%
COP
-8
%
-4
%
-6
%
6
%
CLP
10
%
2
%
-14
%
6
%

1 Negative percentage represents a depreciation of the currency while a positive variance represents an appreciation of the currency


Consolidated Balance Sheets
[In thousands of Canadian dollars]

[Unaudited]

Change
12-31-22
12-31-21
$
% 1
ASSETS
Current
Cash and cash equivalents
71,679
85,963
(14,284
)
17
%
Marketable securities
85,826
63,539
22,287
35
%
Trade receivables
94,890
55,388
39,502
71
%
Other receivables
12,930
5,056
7,874
156
%
Inventories
92,489
72,397
20,092
28
%
Prepaids and deposits
1,704
2,165
(461
)
21
%
Other current financial assets
33,716
13,491
20,225
150
%
Income taxes receivable
2,385
6,970
(4,585
)
66
%
Total current assets
395,619
304,969
90,650
30
%
Marketable securities
15,169
15,169
0
%
Prepaids and deposits
4,355
3,046
1,309
43
%
Right-of-use assets
5,827
4,671
1,156
25
%
Property, plant and equipment
16,806
25,265
(8,459
)
33
%
Investment properties
1,457
(1,457
)
100
%
Intangible assets
338,780
350,299
(11,519
)
3
%
Goodwill
82,274
75,403
6,871
9
%
Other financial assets
142,847
178,952
(36,105
)
20
%
Deferred income tax assets
9,310
2,048
7,262
355
%
Other long-term receivables
43,849
43,431
418
1
%
659,217
684,572
(25,355
)
4
%
Assets held for sale
2,350
(2,350
)
100
%
Total assets
1,054,836
991,891
62,945
6
%

s 1 Percentage change is presented in absolute values


Change
12-31-22
12-31-21
$
% 1
LIABILITIES AND EQUITY
Current
Accounts payable and accrued liabilities
106,061
65,309
40,752
62
%
Lease liabilities
2,578
1,614
964
60
%
Other liabilities
5,793
1,989
3,804
191
%
Bank loans
17,674
26,662
(8,988
)
34
%
Income taxes payable
2,274
7,073
(4,799
)
68
%
Other balances payable
6,941
2,655
4,286
161
%
Total current liabilities
141,321
105,302
36,019
34
%
Accounts payable and accrued liabilities
2,669
281
2,388
850
%
Lease liabilities
5,050
3,417
1,633
48
%
Bank loans
52,398
9,265
43,133
466
%
Other balances payable
23,176
19,235
3,941
20
%
Deferred income tax liabilities
4,365
12,373
(8,008
)
65
%
Total liabilities
228,979
149,873
79,106
53
%
Shareholders’ Equity
Share capital
599,055
628,854
(29,799
)
5
%
Warrants
117
117
0
%
Contributed surplus
23,664
21,776
1,888
9
%
Accumulated other comprehensive income (loss)
41,266
(376
)
41,642
11075
%
Retained earnings
161,755
191,647
(29,892
)
16
%
Total shareholders’ equity
825,857
842,018
(16,161
)
2
%
Total liabilities and shareholders’ equity
1,054,836
991,891
62,945
6
%

[Unaudited]

1 Percentage change is presented in absolute values



12-31-22 vs 12-31-21
Cash and cash equivalents

  • Cash and cash equivalents decreased by $14,284 or 17% mainly due to cash generated through operating activities and funds received under the IFC Loan offset by cash outflows from shares purchased through the NCIB, the in-licensing of AKYNZEO® and ALOXI® from Helsinn as well as fostamatinib from Rigel, repayments on bank loans and foreign exchange gain on cash and cash equivalents. Refer to section Liquidity and Capital Resources for more details.
Trade receivables

  • Trade receivables increased by $39,502 or 71%, mainly due to growth in revenues including the assumption of commercial activities of Exelon® and Akynzeo®, sale of Ambisome® under the MOH Contract, and the growth of our key promoted products.
Other receivables (current)
  • Other receivables increased by $7,874, or 156% mainly due to a receivable of $2,393 from sale of the Medimetriks investments, an increase in interest receivable of $2,965 and an increase in sales and other taxes receivable of $1,592.
Inventories
  • Inventories increased by $20,092, or 28% due to inventory purchases of $10,704 upon transfer of commercial activities of Exelon® and Akynzeo® as well as an increase in inventory levels across key promoted products including Ambisome® in anticipation of the 2023 deliveries of the MOH Contract.
Other financial assets
(current and long term)
Other financial assets decreased by $15,880, or 85%, explained mainly by the following:


Loans and other receivable: increase of $5,023 mainly attributable to net loans issued
of $2,723 and foreign exchange gains of $1,734.

Equity investments and Derivatives: decrease of $1,918 or 24% driven mainly by the disposal of Medimetriks equity investments during the period and the revaluation of equity investments and derivatives.

Funds: decrease of $18,985 due to negative mark-to-market adjustments of $23,325 driven mostly by the decline in the share prices of the publicly-traded equities held by our strategic fund investments due to general market conditions, distributions received and receivable of $6,478, offset by capital calls of $6,307 and foreign exchange gains of $4,511.

Income tax receivable
  • Decrease is mainly due collection of tax refunds.
Property, plant and equipment
  • Property plant and equipment decreased by 8,459 or 33% mainly due to the impairment of certain property, plant and equipment in Argentina related to branded generics intellectual property.
Intangible assets
  • Intangible assets decreased by $11,519 or 3% mainly due to amortization and impairment charge during the period, offset by upfront payments and certain milestones primarily related to in-licensing of AKYNZEO® and ALOXI® from Helsinn, fostamatinib from Rigel and the appreciation of the USD vs. the CAD.
Goodwill
  • Increase due to the appreciation of certain LATAM currencies during the period.
Deferred income tax asset
Increase is mainly explained by additional deferred tax assets recognized on tax losses generated in certain jurisdictions and certain temporary differences related to financial assets and change in temporary differences related to intercompany transactions.



12-31-22 vs 12-31-21
Other receivables (long-term)
  • No significant variance.
Accounts payable and accrued liabilities
(current and long term)
  • Increase in accounts payable and accrued liabilities balance by $43,140, or 64%, driven by:
    1. increase of $25,772 related to purchase of Exelon® & AKYNZEO® inventory driven by the transfer of the commercial activities to Knight and purchases of Ambisome® in anticipation of the MOH Contract deliveries of 2023;
    2. higher payables due to inventory purchases of our key promoted products and, timing of accruals, payments to and purchases from certain suppliers.
Bank loans (current and long term)
  • Increase in bank loans by $34,145 or 95% mainly due to a five-year loan from IFC denominated in select LATAM currencies of $51,478 and accrued interest, partially offset by loan repayments of $17,542.
Income tax payable
  • Decrease is mainly explained by the settlement of certain prior year income tax liabilities, instalments and lower current tax accruals in certain jurisdictions.
Other balances payable (current and long term)
  • Increase in other payables by $8,227 due to certain milestones mainly related to in-licensing of AKYNZEO® and ALOXI® from Helsinn, fostamatinib from Rigel and appreciation of the USD vs the CAD.
Deferred income tax liability
  • Decrease is mainly explained by the recognition of deferred income tax recovery on amortization of certain definite-life intangible assets acquired by the Company, the change in temporary difference related to intercompany transactions and certain impairment on intangible assets.
Share capital
  • Decrease due to the purchase of Knight’s common shares though the NCIB, partially offset by share issuance under ESPP.
Contributed surplus
  • Increase related to share-based compensation expense.

Liquidity and Capital Resources

The Company’s Investment Policy governs the investment activities relating to cash resources. An Investment Committee composed of representatives from management and the Board of Directors monitors compliance with said policy. The Company invests in strategic investments in the form of equity funds, debt funds, equity or liquid investment securities with varying terms to maturity, selected with regard to the expected timing of investments and expenditures for continuing operations and prevailing interest rates.

The Company believes that its existing cash, cash equivalents and marketable securities as well as cash generated from operations are sufficient to finance its current operations, working capital requirements and future product and corporate acquisitions. The table below sets forth a summary of cash flow activity and should be read in conjunction with our consolidated statements of cash flows.


[Unaudited]

Change
YTD
Change
Q4-22
Q4-21
$
% 1
2022
2021
$
% 1
Net cash from operating activities
4,752
4,681
71
2
%
40,481
44,618
(4,137
)
9
%
Net cash used in investing activities
(65,024
)
9,469
(74,493
)
787
%
(63,079
)
(105,279
)
42,200
40
%
Net cash from (used in) financing activities
29,858
(22,886
)
52,744
230
%
1,762
(78,310
)
80,072
102
%
Increase in cash and cash equivalents during the period
(30,414
)
(8,736
)
(21,678
)
248
%
(20,836
)
(138,971
)
118,135
85
%
Net foreign exchange difference
271
2,209
(1,938
)
88
%
6,552
(4,658
)
11,210
241
%
Cash and cash equivalents beginning of the period
101,822
92,490
9,332
10
%
85,963
229,592
(143,629
)
63
%
Cash and cash equivalents, end of the period
71,679
85,963
(14,284
)
17
%
71,679
85,963
(14,284
)
17
%
Marketable securities 2 , end of the period
100,995
63,539
37,456
59
%
100,995
63,539
37,456
59
%
Cash and cash equivalents, and marketable securities 2 , end of the period
172,674
149,502
23,172
15
%
172,674
149,502
23,172
15
%
Cash and cash equivalents, net of bank loans
1,607
50,036
(48,429
)
97
%
1,607
50,036
(48,429
)
97
%

1 Percentage change is presented in absolute values .
2 Including marketable securities pledged as restricted cash collateral under the IFC loan.



Q4-22
YTD-22
Net cash from operating activities
Primarily relates to cash generated through revenues and interest received, offset by operating expenses including salaries, research and development expenses, advertising and promotion costs, interest paid and other corporate expenses. Cash flows from operating activities exclude revenues and expenses not affecting cash, such as unrealized and realized gains or losses on financial assets, share based compensation expense, depreciation and amortization, unrealized foreign exchange gains or losses, hyperinflation gains, other income, deferred other income, and net changes in non-cash balances relating to operations.

For the three-month period ended December 31, 2022, cash inflow from operations was $4,752. The net loss for the quarter plus adjustments of non-cash items such as depreciation, amortization and impairment is $6,280 which is offset by an increase in working capital of $1,528. The increase in the working capital is mainly due to the transition of commercial activities to Knight related to Exelon® and Akynzeo®. The working capital levels are expected to normalize during the first half of 2023.

Furthermore, the net cash from operating activities included an inflow of $2,287 related to net interest received mainly driven by the timing of maturity of marketable securities.

For the year ended December 31, 2022, cash inflow from operations was $40,481. The net loss for the year plus adjustments of non-cash items such as non-cash items such as depreciation, amortization and impairment is $50,470 which is offset by an increase in working capital of $9,989. The increase in the working capital is mainly due to the transition of commercial activities to Knight related to Exelon® and Akynzeo®. The working capital levels are expected to normalize during the first half of 2023.

Furthermore, the net cash from operating activities included an inflow of $7,608 related to net interest received mainly driven by the timing of maturity of marketable securities as well as an inflow of $6,030 from the settlement with former shareholders of GBT.
Net cash from investing activities
For the three-month period ended December 31, 2022, cash flows were mainly driven by:
  • net purchase of marketable securities of $57,418 driven by higher interest rates on GICs including the requirement under IFC loan for restricted cash collateral of 35% of loan balance outstanding;
  • distributions from life sciences funds of $577, offset by investment in funds of $531;
  • acquisition of intangibles and property and equipment of $6,653 mainly due to certain sales milestones payment;
  • proceeds from disposal of investments in Medimetriks of $1,742.
For the year ended December 31, 2022, cash flows were mainly driven by:
  • net purchase of marketable securities of $36,825 driven by higher interest rates and requirement under IFC loan to have restricted cash collateral of 35% of loan balance outstanding;
  • acquisition of intangibles and property and equipment of $25,816 mainly due to upfront payments and certain milestones related to in-licensing of AKYNZEO® and ALOXI® from Helsinn as well as fostamatinib from Rigel, and
  • distributions from life sciences funds of $3,985, offset by investment in funds of $3,831;
  • issuance of additional strategic loan of $2,741 to Synergy, and
  • proceeds from disposal of investments in Medimetriks of $1,742.
Net cash from financing activities
Cash flows from financing activities were mainly due to the repurchase of common shares through the NCIB, principal repayments on bank loans, principal repayments on lease liabilities, proceeds from bank loans and proceeds from the participation of employees and directors in the Company’s share purchase plan.


The Company had the following indebtedness as at the end of the following periods:

As at December 31, 2022
[Unaudited]

Currency of
debt
Interest rate
Effective
interest rate
Maturity
Current
$
Non-current
$
Total
$
Banks
Itaú Unibanco Brasil
BRL
1.65% + CDI
13.36
%
Dec 8, 2023
8,487
8,487
Bancolombia
COP
2.28% + IBR
8.07
%
Oct 12, 2026
2,299
6,194
8,493
Banco ICBC Argentina 1
ARS
77% 2
77% 2
N/A
344
344
Banco Itaú Argentina 1
ARS
76% 3
76% 3
N/A
1,270
1,270
IFC
BRL
1.6% + CDI
15.83
%
Oct 15, 2027
3,121
23,309
26,430
IFC
CLP
7.71
%
7.86
%
Oct 15, 2027
1,202
9,198
10,400
IFC
COP
1.6% + IBR
13.29
%
Oct 15, 2027
735
10,613
11,348
IFC
MXN
1.6% + TIIE
13.07
%
Oct 15, 2027
216
3,084
3,300
Total Bank Loans
17,764
52,398
70,072

1 Overdraft balances
2 Fixed rate renewed monthly
3 Fixed rate renewed daily


As at December 31, 2021
Currency of
debt
Interest rate
Effective
interest rate
Maturity
Current
$
Non-current
$
Total
$
Banks
Itaú Unibanco Brasil
BRL
1.65% + CDI
5.97
%
Dec 8, 2023
15,028
15,028
Itaú Unibanco Brasil
BRL
2.20% + CDI
11.35
%
Dec 28, 2022
5,601
5,601
Bancolombia
COP
2.28% + IBR
4.47
%
Oct 12, 2026
2,448
9,265
11,713
Banco ICBC Argentina 1
ARS
42% 2
42
%
N/A
694
694
Banco Itaú Argentina 1
ARS
40% 3
40
%
N/A
2,891
2,891
Total Bank Loans
26,662
9,265
35,927

1 Overdraft balances
2 Fixed rate renewed monthly
3 Fixed rate renewed daily

CONSOLIDATED STATEMENTS OF CASH FLOWS

[In thousands of Canadian dollars]

[Unaudited]

Three months ended December 31,
Year ended December 31,
2022
2021
2022
2021
OPERATING ACTIVITIES
Net (loss) income for the period
(15,188
)
(8,301
)
(29,892
)
15,675
Adjustments reconciling net income to operating cash flows:
Depreciation and amortization
20,194
19,001
62,621
47,915
Net gain (loss) on financial instruments
(8,824
)
(2,300
)
20,677
(18,944
)
Unrealized foreign exchange loss (gain)
(1,044
)
3,968
(8,479
)
2,881
Loss on disposal and impairment of non-current assets
21,904
496
23,984
496
Other operating activities
(10,762
)
(2,086
)
(18,441
)
(4,032
)
6,280
10,778
50,470
43,991
Changes in non-cash working capital and other items
(1,528
)
(6,097
)
(9,989
)
627
Cash inflow from operating activities
4,752
4,681
40,481
44,618
INVESTING ACTIVITIES
Purchase of marketable securities
(100,995
)
3
(181,642
)
(47,892
)
Proceeds on maturity of marketable securities
43,577
90
144,817
146,986
Investment in funds
(531
)
(5,466
)
(3,831
)
(16,429
)
Proceeds from distribution of funds
577
17,519
3,985
30,931
Purchase of intangible assets
(4,407
)
(153
)
(22,931
)
(220,351
)
Other investing activities
(3,245
)
(2,524
)
(3,477
)
1,476
Cash (outflow) inflow from investing activities
(65,024
)
9,469
(63,079
)
(105,279
)
FINANCING ACTIVITIES
Repurchase of common shares through Normal Course Issuer Bid
(8,684
)
(23,508
)
(30,069
)
(64,415
)
Principal repayment on bank loans
(12,095
)
(5,688
)
(17,542
)
(20,599
)
Proceeds from bank loans
51,361
7,098
51,783
9,423
Other financing activities
(724
)
(788
)
(2,410
)
(2,719
)
Cash inflow (outflow) from financing activities
29,858
(22,886
)
1,762
(78,310
)
(Decrease) in cash and cash equivalents during the period
(30,414
)
(8,736
)
(20,836
)
(138,971
)
Cash and cash equivalents, beginning of the period
101,822
92,490
85,963
229,592
Net foreign exchange difference
271
2,209
6,552
(4,658
)
Cash and cash equivalents, end of the period
71,679
85,963
71,679
85,963
Cash and cash equivalents
71,679
85,963
Short-term marketable securities
85,826
63,539
Long-term marketable securities
15,169
Total cash, cash equivalents and marketable securities
172,674
149,502



Stock Information

Company Name: Knight Therapeutics Inc.
Stock Symbol: GUD:CC
Market: TSXC
Website: gud-knight.com

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