MBIO - Mustang Bio plans to start phase 1 trial of combo therapy for brain cancer
Mustang Bio (NASDAQ:MBIO) said plans to begin a phase 1 trial combining CAR T cells and oncolytic virus to treat recurrent glioblastoma (rGBM), a type of brain cancer. The company said its decision was supported by interim data from two ongoing phase 1 trials evaluating two candidates, MB-108 (C134 oncolytic virus) and MB?101 (City of Hope’s IL13R?2?targeted CAR T cell therapy). MB?101 and MB-108 were well tolerated in patients with recurrent GBM in ongoing phase 1 trials, the company noted in an April 13 press release. Mustang Bio (MBIO) added that preclinical data also support the safety of administering the two therapies sequentially in a regimen designated as MB-109.
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Mustang Bio plans to start phase 1 trial of combo therapy for brain cancer