OGN - Oragenics announces early toxicology data for intranasal COVID-19 vaccine

• Development-stage biotech Oragenics, Inc. ( NYSE: OGN ) announced initial data on Wednesday from an ongoing Good Laboratory Practice (GLP) toxicology study for NT-CoV2-1, an intranasal COVID-19 vaccine candidate.
• The data, generated from a rabbit model, indicate a safety profile and immune responses for NT-CoV2-1, the company said, adding that the readout is expected to support regulatory filings required to advance the candidate in a Phase 1 trial.
• The final toxicology report, which will include data from ongoing histopathology evaluation, is expected by the year-end. The company plans to start the Phase 1 trial for NT-CoV2-1 by early 2023.
• “We believe our intranasal vaccine candidate will have the potential to reduce transmission and offers a needle-free COVID-19 vaccine option,” OGN’s Chief Executive Kimberly Murphy said.
• A former executive at GSK ( GSK ), Murphy took the leadership of OGN in June.

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