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VYNE Therapeutics (VYNE) down 5% premarket as the company's stock-split of common shares becomes effective today.On Feb. 11, the Company's Board of Directors approved a reverse stock split at a ratio of 1-for-4.Once effective, the reverse stock split will reduce the number of common shares issued and outstanding from ~205M to ~51M.In addition, the number of authorized shares will be reduced by a corresponding ratio.