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Shares of Allakos (NASDAQ: ALLK) are crashing 88% lower as of 10:17 a.m ET on Wednesday. The huge decline came after the company announced results from its phase 3 Enigma 2 and its phase 2/3 Kryptos clinical studies evaluating lirentelimab.
Allakos reported that both clinical studies met their histologic co-primary endpoints. However, neither study achieved statistically significant improvement on patient-reported symptomatic co-primary endpoints.