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The typical course of drug R&D goes something like this:
a druggable target is identified
early discovery efforts are launched
a lead drug candidate is selected
preclinical studies are conducted
an IND is filed
PhI, PhII and PhIII trials are run in humans
Each of these steps requires successful completion of the previous ones for the sake of safety, efficient resource allocation and ultimately as a matter of due process. Paramount to drug R&D is safety, which is why drug candidates are first tested in animals and then, typically,