Aurigene Oncology to Showcase Innovative A-PROX Platform at the AACR-NCI-EORTC International Conference 2025
MWN-AI** Summary
Aurigene Oncology Limited, a biopharmaceutical firm focused on innovative cancer therapies, is set to present groundbreaking findings from its proprietary A-PROX platform at the upcoming AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, running from October 22 to 26, 2025. The A-PROX platform merges library screening, advanced chemistries, and proprietary assays to enhance the discovery of targeted protein degraders and molecular glues.
Aurigene's recent advancements include several pre-clinical candidates, notably a SMARCA2-selective degrader that recently received Investigational New Drug approval from the FDA. Additionally, their portfolio includes a pan-KRAS degrader, a SMARCA4-selective degrader, and a p300 degrader. CEO Dr. Murali Ramachandra emphasized that A-PROX marks a vital step in the rational design of such therapies, with the potential to revolutionize cancer treatment through the targeting of previously undruggable pathways.
At the conference, Aurigene plans to highlight several of its pipeline programs. A poster presentation will focus on an orally bioavailable SMARCA2-selective degrader that demonstrates impressive effectiveness against cancers with SMARCA4 mutations. Other presentations will include studies on a dual antibody with single-agent phagocytosis activity, macrocyclic KIF18A inhibitors for chromosomally unstable tumors, and a new Cbl-b inhibitor aimed at cancer immunotherapy.
Founded in 2001, Aurigene is a subsidiary of Dr. Reddy’s Laboratories and boasts a rich pipeline that includes first-in-class therapies and promising pre-clinical programs. The company’s commitment to developing effective oncology treatments continues to position it as a leader in the biopharmaceutical industry. For additional details, visit Aurigene’s website.
MWN-AI** Analysis
Aurigene Oncology Limited is poised for a significant spotlight at the upcoming AACR-NCI-EORTC International Conference, scheduled for October 22-26, 2025. With a focus on their A-PROX platform, the company is set to showcase transformative advancements in the field of oncology, particularly through their novel targeted protein degradation approaches. Investors should view this conference as an essential event reflecting Aurigene's potential positioning in the oncology landscape.
The proprietary A-PROX platform integrates advanced technologies that accelerate the discovery of targeted therapies, highlighted by the recently FDA-approved SMARCA2-selective degrader. This therapeutic innovation is crucial given the challenges of targeting "undruggable" cancer pathways, thus potentially opening substantial market opportunities. Notably, the use of long-acting injectables (LAI) promises enhanced patient compliance, making these therapies more appealing to healthcare providers and payers.
The presentations scheduled at the conference are also noteworthy. The focus on an orally bioavailable SMARCA2 degrader and the development of a differentiated anti-SIRP dual antibody reflect a strategic move towards expanding Aurigene's pipeline with unique offerings. These presentations may attract interest from pharmaceutical partners and investors alike, potentially leading to collaborative opportunities or further funding.
As Aurigene continues to develop its preclinical and clinical pipelines, monitoring the outcomes of these presentations will be crucial. Additionally, the potential market implications of their novel therapies should be factored into investment decisions. With established corporate backing from Dr. Reddy’s Laboratories and a promising pipeline, Aurigene represents a compelling option for investors seeking exposure in the biotech space focused on oncology. Nevertheless, due diligence on their clinical progress and competitive positioning would be prudent in the rapidly evolving biopharmaceutical landscape.
**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.
Aurigene Oncology Limited , a clinical-stage biopharmaceutical company developing novel therapies in oncology, today announced that it will present new data from its proprietary Targeted Protein Degradation (TPD) and Proximity Inducer Platform (A-PROX) at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics being held at the Hynes Convention Center in Boston, MA, from October 22–26, 2025.
Aurigene’s A-PROX platform integrates library screening, direct-to-biology chemistries, proprietary ternary complex assays, modelling algorithms , and structure-based design to accelerate the discovery and optimization of both protein degraders, molecular glues and proximity inducers.
Through this integrated approach, Aurigene has advanced a strong pre-clinical portfolio of next-generation degraders, including a SMARCA2-selective degrader, which recently received Investigational New Drug (IND) approval from the United States Food and Drug Administration (FDA); a pan-KRAS degrader; a SMARCA4-selective degrader; and a p300 degrader.
“Our A-PROX platform represents a significant step forward in the rational discovery of targeted protein degraders and molecular glues,” said Dr. Murali Ramachandra, CEO of Aurigene Oncology Ltd. “We are excited to share our progress at the AACR-NCI-EORTC conference and continue advancing differentiated therapies that have the potential to transform cancer treatment.”
These programmes underscore Aurigene’s capability to deliver potent, paralogue-selective, and mutant-agnostic degraders, enabling the targeting of previously undruggable oncology pathways. Aurigene’s proprietary long-acting injectable (LAI) formulation has enabled infrequent intravenous dosing, just once every three weeks for most molecules, while maintaining excellent efficacy.
Poster Presentations
Title: Identification of an orally bio-available SMARCA2 selective degrader for treatment of SMARCA4 mutant cancers
Presenting Author: Susanta Samajdar
Presentation Date/Time: Oct 25 12:30-4PM ET
Abstract Number: C025
This presentation describes the identification and characterization of an orally bioavailable SMARCA2 degrader with good potency and selectivity over SMARCA4. SMARCA2 and SMARCA4 regulate chromatin architecture by mobilizing and repositioning nucleosomes on DNA, which is critical for various genomic functions, including transcriptional regulation, DNA recombination and repair, and mitotic chromosome segregation. Loss-of-function mutations or silencing of SMARCA4 are frequently observed in multiple cancer types, where tumorigenesis becomes dependent on the residual SMARCA2 degrader with good potency and selectivity over SMARCA4. In this study, the lead SMARCA2 degrader demonstrated potent antitumor activity, driven by efficient SMARCA2 degradation, in multiple SMARCA4-deficient cell line-derived xenograft (CDX) models at well-tolerated dose levels. Additionally, with the use of Aurigene’s proprietary long-acting injectable (LAI) formulation, AUR110, a candidate with US-FDA clearance for first-in-human studies, has shown potent and comparable anti-tumor activity following once every three week intravenous dosing.
Aurigene will also be showcasing other pipeline programmes in poster presentations at the conference, including:
Title: Discovery and development of a highly differentiated, efficacious, first-in-class anti-SIRP?/? dual antibody with single agent phagocytosis activity
Presenting Author: Subhra Chakrabarty
Presentation Date/Time: Oct 24 12:30-4PM ET
Abstract Number: B077
Title: Discovery and preclinical characterization of novel macrocyclic KIF18A inhibitors for treatment of chromosomally instable tumors
Presenting Author: Susanta Samajdar
Presentation Date/Time: Oct 23 12:30-4PM ET
Abstract Number: A030
Title: Development of a Differentiated, Best-in-Class oral Cbl-b inhibitor with Robust Immune Activation and Favourable Safety for Cancer Immunotherapy
Presenting Author: Susanta Samajdar
Presentation Date/Time: Oct 25 12:30-4PM ET
Abstract Number: C059
About Aurigene Oncology Limited:
Aurigene Oncology Limited, a wholly owned subsidiary of Dr. Reddy’s Laboratories (BSE: 500124, NSE: DRREDDY, NYSE: RDY, NSEIFSC: DRREDDY), is a clinical stage biotech committed to bringing in novel and effective therapeutics for the treatment of cancer. Founded in 2001, Aurigene has contributed to the discovery of 21 novel chemical entities for clinical development. Some of these molecules were in collaboration with global Pharma and biotech companies while remaining were developed on its own. Aurigene’s clinical pipeline with encouraging early clinical activity includes first- in-class oral inhibitor of immune checkpoint protein CD47, best-in-class inhibitor DHODH, an enzyme in the pyrimidine biosynthesis pathway, best-in-class inhibitor of acetyl transferases CBP and p300 and a best-in-class inhibitor of MALT1 protease impacting B-cell receptor signalling. Aurigene also has a strong pre-clinical pipeline, including advanced programs based on selective degradation of SMRACA2, pan-KRAS, SMARCA4 and p300.
For more information, please visit: www.aurigene.com and follow us on LinkedIn and X .
View source version on businesswire.com: https://www.businesswire.com/news/home/20251020997859/en/
Email : bd@aurigene.com
FAQ**
How does Aurigene Oncology's A-PROX platform distinguish itself from other drug discovery platforms, and what role does Dr. Reddy's Laboratories Ltd RDY play in its operations?
Can you provide more details on the progress of Aurigene's other pipeline programs, particularly in relation to the collaboration with Dr. Reddy's Laboratories Ltd RDY?
What are the anticipated next steps for the SMARCA2 selective degrader after receiving IND approval, and how does Dr. Reddy's Laboratories Ltd RDY plan to support its development?
How will the presentations at the AACR-NCI-EORTC conference influence investor confidence in Aurigene's future partnerships with Dr. Reddy's Laboratories Ltd RDY and beyond?
**MWN-AI FAQ is based on asking OpenAI questions about Dr. Reddy's Laboratories Ltd (NYSE: RDY).
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