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OKYO Pharma Announces Chairman and Founder Acquires Shares

MWN-AI** Summary

OKYO Pharma Limited (NASDAQ: OKYO), a biopharmaceutical company specializing in ophthalmology, has announced that Gabriele Cerrone, its Executive Chairman and founder, has acquired an additional 210,000 ordinary shares of the company, increasing his total shareholding to 10,382,677 shares. This acquisition underscores Cerrone's commitment to OKYO's mission of developing innovative treatments for ocular conditions, particularly neuropathic corneal pain (NCP), a debilitating condition currently lacking an FDA-approved therapy.

At the forefront of OKYO's research is urcosimod, previously known as OK-101, which is designed to address both inflammation and pain within the eye. Urcosimod functions as a lipid-conjugated chemerin peptide agonist targeting the ChemR23 G-protein coupled receptor found on immune cells and neurons in the ocular environment. This unique design aims to enhance urcosimod's efficacy and prolong its effects by mitigating washout in the eye.

Urcosimod has demonstrated promising results in animal models for treating dry eye disease and corneal neuropathic pain, and its potential was further highlighted in a recent completed Phase 2 trial involving 240 patients, where it showed statistical significance in multiple endpoints for dry eye disease treatment. Simultaneously, OKYO has also completed a Phase 2, randomized, placebo-controlled trial of urcosimod specifically for neuropathic corneal pain.

As a clinical stage biopharmaceutical company, OKYO Pharma remains focused on the discovery and development of groundbreaking therapies for eye-related conditions, aiming to improve the quality of life for patients suffering from these painful disorders. For more information, visit their website at www.okyopharma.com.

MWN-AI** Analysis

The recent announcement from OKYO Pharma (NASDAQ: OKYO) regarding the acquisition of 210,000 ordinary shares by Executive Chairman Gabriele Cerrone may signal positive sentiment within the market. With Cerrone now holding over 10.3 million shares, this significant purchase can be seen as a strong vote of confidence in the company’s future, especially in light of its pivotal development timelines.

OKYO Pharma is focused on addressing unmet medical needs in ophthalmology, particularly through its lead product, urcosimod, which is in advanced clinical stages for treating neuropathic corneal pain (NCP). The lack of FDA-approved therapies for NCP creates a substantial opportunity, given that the current market is seeking effective treatments for chronic eye-related pain conditions. The encouraging results from the recently completed Phase 2 clinical trial could pave the way for further investment and potential partnership opportunities, enhancing the company's valuation in the pharmaceutical landscape.

From a financial perspective, investors should consider the implications of Cerrone's stock purchase. Management’s confidence in their product pipeline can often translate into higher investor belief, which may drive share prices upward in the near term. However, prospective investors should monitor the data emerging from ongoing trials closely, alongside any news related to regulatory approvals or partnerships, which could impact the stock considerably.

The current trading environment reflects a broader market interest in biotech and innovative therapies, particularly as public health needs evolve. Given the encouraging clinical data from OKYO, the company appears well-positioned for growth, making it a potential investment opportunity for those seeking exposure to biotech stocks, particularly in the ophthalmology space. Nevertheless, as always, prudent due diligence and risk assessment are essential when considering investments in speculative clinical-stage companies.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

LONDON and NEW YORK, Oct. 16, 2025 (GLOBE NEWSWIRE) -- OKYO Pharma Limited (NASDAQ: OKYO ), an ophthalmology-focused bio-pharmaceutical company which is developing urcosimod to treat neuropathic corneal pain (NCP), an ocular condition associated with chronic and often severe nerve-related pain but without an FDA-approved therapy, today announces it has been informed that Panetta Partners Limited, an entity in which Gabriele Cerrone, the Executive Chairman has a beneficial interest, has acquired 210,000 of the Company’s ordinary shares on NASDAQ, bringing his total holding to 10,382,677 shares.

About Urcosimod (Formerly called OK-101)
Urcosimod is a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor which is typically found on immune cells of the eye responsible for the inflammatory response, as well as on neurons and glial cells in the dorsal root ganglion. Urcosimod was developed using a membrane-anchored-peptide technology to produce a novel long-acting drug candidate for treating ocular diseases. Urcosimod has been shown to produce anti-inflammatory and pain-reducing activities in mouse models of dry eye disease and corneal neuropathic pain, respectively, and is designed to combat washout through the inclusion of the lipid anchor built into the drug molecule to potentially enhance the efficacy of urcosimod within the ocular environment. Urcosimod showed clear statistical significance in multiple endpoints in a 240-patient completed Phase 2, multi-center, double-masked, placebo-controlled trial to treat dry eye disease, and just completed a randomized, placebo-controlled, double-masked Phase 2 trial of urcosimod to treat neuropathic corneal pain.

About OKYO
OKYO Pharma Limited (NASDAQ: OKYO) is a clinical stage biopharmaceutical company developing innovative therapies for the treatment of neuropathic corneal pain and dry eye disease, with ordinary shares listed for trading on the NASDAQ Capital Market. OKYO is focused on the discovery and development of novel molecules to treat neuropathic corneal pain and dry eye disease. A Phase 2 trial of urcosimod to treat neuropathic corneal pain patients was just completed by OKYO.

For further information, please visit www.okyopharma.com .

Inquiries:

Business Development & Investor Relations Paul Spencer +44 (0)20 7495 2379



FAQ**

What are the potential implications of Gabriele Cerrone's acquisition of additional shares in OKYO Pharma Limited (NASDAQ: OKYO) for investor confidence in the company's upcoming clinical trials?

Gabriele Cerrone's acquisition of additional shares in OKYO Pharma Limited may bolster investor confidence in the company's upcoming clinical trials, signaling insider belief in its potential success and long-term value.

How does the success of Urcosimod in Phase 2 trials impact the strategic positioning of OKYO Pharma Limited OKYO in the ophthalmology market, particularly regarding neuropathic corneal pain?

The success of Urcosimod in Phase 2 trials positions OKYO Pharma Limited strategically in the ophthalmology market by enhancing its credibility and potential market share in treating neuropathic corneal pain, potentially attracting partnerships and investments.

Considering the anti-inflammatory properties of Urcosimod, what competitive advantages might OKYO Pharma Limited OKYO have over existing treatments for dry eye disease and neuropathic corneal pain?

OKYO Pharma Limited's Urcosimod may offer a competitive advantage in treating dry eye disease and neuropathic corneal pain due to its targeted anti-inflammatory properties, potentially providing greater efficacy and a more favorable side effect profile compared to existing therapies.

What are the projected market trends for ophthalmology-focused biopharmaceutical companies like OKYO Pharma Limited OKYO, especially as they relate to innovative therapies for nerve-related ocular conditions?

Projected market trends for ophthalmology-focused biopharmaceutical companies like OKYO Pharma Limited indicate significant growth driven by increasing demand for innovative therapies targeting nerve-related ocular conditions, fueled by advances in research and technology, alongside a rising patient population.

**MWN-AI FAQ is based on asking OpenAI questions about OKYO Pharma Limited (NASDAQ: OKYO).

OKYO Pharma Limited

NASDAQ: OKYO

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Biotechnology & Life Sciences
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