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Avacta Announces Preclinical and Translational Presentations of pre|CISION® Platform Candidates at the 2026 AACR Annual Conference

MWN-AI** Summary

Avacta Therapeutics, a clinical-stage biopharmaceutical company, announced its participation in the 2026 American Association for Cancer Research (AACR) Annual Meeting, scheduled for April 17-22, 2026, in San Diego, California. The company will present two key studies focusing on its innovative pre|CISION® platform, which is designed to enhance cancer treatment by delivering potent therapeutics directly to tumors while minimizing systemic exposure.

The first presentation will showcase "AVA6103," a peptide-drug conjugate enabled by fibroblast activation protein (FAP). This study highlights the compound's ability to release the chemotherapy agent exatecan within the tumor microenvironment, demonstrating effective antitumor activity. This session, categorized under tumor microenvironments and immunomodulation, will take place on April 21, 2026, from 2:00 to 5:00 PM PDT.

The second presentation will focus on the characterization and translational development of novel pre|CISION® technology compounds that deliver dual payloads to the tumor site following FAP cleavage. By targeting the unique protease activity prevalent in most solid tumors, these compounds aim to maximize therapeutic effects while reducing collateral damage to healthy tissues.

Avacta’s pre|CISION® platform leverages its proprietary technology to conjugate anticancer payloads with peptides specifically designed to be activated in the tumor microenvironment, providing advantages over traditional antibody-drug conjugates. This approach promises to optimize dosing and improve patient outcomes by concentrating therapy precisely where it is needed.

The company looks forward to sharing these findings, which reflect its commitment to advancing effective cancer therapies. For additional information, interested parties can reach out to Avacta or its appointed advisors through various contact channels provided.

MWN-AI** Analysis

Avacta Therapeutics (AIM: AVCT) is making noteworthy strides in the field of oncology with its pre|CISION® platform, which could represent a significant innovation in targeted cancer therapies. Following the announcement of two upcoming presentations at the 2026 AACR Annual Meeting, investors should closely monitor these developments as they could have considerable implications for the company’s stock performance.

The presentations, particularly on AVA6103 and the characterization of pre|CISION® technology compounds, highlight the platform's potential in delivering potent therapies specifically to the tumor microenvironment. This targeted approach can improve the effectiveness of treatments while minimizing toxicity to healthy tissues, which is a critical concern in cancer therapy. Positive data or strong preliminary results presented at AACR could serve as a catalyst for the stock price, attracting both retail and institutional investors.

Investors should consider the broader market sentiment towards biotechnology firms focused on innovative cancer treatments, which has generally been bullish, especially when robust data or advancements are shared. The successful translation of Avacta's research into effective therapies could position the company favorably against its competitors in the oncological space.

However, as with any investment in biotech, it is essential to recognize the inherent risks. The success of clinical trials can be unpredictable, and regulatory hurdles remain a constant factor. Investors should have a watchful eye on upcoming data releases, investor calls, and any news regarding partnerships or collaborations that can enhance the company’s market position.

In conclusion, Avacta presents an intriguing opportunity for growth within the biotech sector, especially considering the upcoming AACR presentations. A prudent approach would involve staying informed on key developments while assessing both market potential and risk factors associated with its innovative pipeline.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

LONDON and PHILADELPHIA, March 17, 2026 (GLOBE NEWSWIRE) -- Avacta Therapeutics (AIM: AVCT, "the Company", "Avacta"), a clinical stage biopharmaceutical company developing pre|CISION®, a tumor-activated oncology delivery platform, today announced it will deliver two presentations at the American Association for Cancer Research (AACR) Annual Meeting 2026, taking place from 17 April 2026 to 22 April 2026 in San Diego, California, USA.

Details of the two presentations:

Title: AVA6103 is a FAP-enabled pre|CISION® peptide-drug conjugate delivering sustained release of exatecan in the tumor microenvironment with potent antitumor activity

Authors: Curtis Rink, Tom Clough, Ellen Watts, Folake Orafidiya, Marine Houée, Sophie Brown, Victoria Juskaite, Gezim Lahu, Ruairidh Edwards, Karen Campbell, Dave Liebowitz, David Jones, Michelle Morrow, Francis Wilson

Poster number and Location: 5846, Section 17, Board 15
Session: Tumor Microenvironment, Multi-specifics, and Immunomodulation
Section: Experimental and Molecular Therapeutics
Timing: Tuesday, 21 April 2026, 2:00-5:00pm PDT

Title: Characterization and translational development of novel pre|CISION® technology compounds delivering complementary dual payloads to the tumor microenvironment following FAP cleavage

Authors: Victoria Juskaite, Tom Clough, Ellen Watts , Alexa Kennedy, Iva Zlatareva, Folake Orafidiya, Hanna Buist, Jannah Jeon, Greg Billenness, Douglas Sammon, Sophie Brown, Curtis Rink , Ruairidh Edwards, Vidicha Chunilal, Manuel Pinto, Dave Liebowitz, Francis Wilson, Michelle Morrow, David Jones

Poster number and Location: 5656, Section 10, Board 26
Session: Antibody-Drug Conjugates and Linker Engineering 4
Section: Experimental and Molecular Therapeutics
Timing: Tuesday 21 April 2026, 2:00-5:00pm PDT

For further information from Avacta, please contact:

Avacta Group plc
Christina Coughlin, Chief Executive Officer
https://avacta.com/
via Cohesion Bureau
  
Strand Hanson Limited (Nominated Adviser)
James Harris / Chris Raggett / James Dance
www.strandhanson.co.uk
  
Zeus (Broker)
James Hornigold / George Duxberry / Dominic King
www.zeuscapital.co.uk
  
Cohesion Bureau
Communications / Media / Investors
Richard Jarvis
avacta@cohesionbureau.com
  

About Avacta https://avacta.com/

Avacta Therapeutics is a clinical-stage life sciences company expanding the reach of highly potent cancer therapies with the pre|CISION® platform. pre|CISION® is a proprietary payload delivery system based on a tumor-specific protease (fibroblast activation protein or FAP) that is designed to concentrate highly potent payloads in the tumor microenvironment while sparing normal tissues.

Our innovative pipeline consists of pre|CISION® peptide drug conjugates (PDC) or Affimer® drug conjugates (AffDC) that leverage the tumor-specific release mechanism, providing unique benefits over traditional antibody drug conjugates.

The pre|CISION® platform comprises an anticancer payload conjugated to a proprietary peptide that is a highly specific substrate for fibroblast activation protein (FAP) which is upregulated in most solid tumors compared with healthy tissues. The pre|CISION® platform harnesses this tumor specific protease to cleave pre|CISION® peptide drug conjugates and pre|CISION® antibody/Affimer® drug conjugates in the tumor microenvironment, thus releasing active payload in the tumor and reducing systemic exposure and toxicity, allowing dosing to be optimized to deliver the best outcomes for patients.
This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the London Stock Exchange. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.


FAQ**

How is Avacta Group Plc AVCTF leveraging the pre|CISION® platform to enhance cancer treatment outcomes at the AACR Annual Meeting in San Diego, and how might this impact investors in London and Philadelphia?
Avacta Group Plc is showcasing its pre|CISION® platform at the AACR Annual Meeting to demonstrate improved precision in targeted cancer therapies, potentially boosting investor confidence and interest in London and Philadelphia due to enhanced treatment outcomes and market potential.
In what ways can the presentations by Avacta Group Plc AVCTF at AACR 20influence the future funding landscape for biotech companies in both London and Philadelphia?
The presentations by Avacta Group Plc at AACR 2026 could enhance investor confidence and attract funding for biotech firms in London and Philadelphia by showcasing innovative advancements and potential clinical successes, thereby influencing investor appetite and market trends.
What implications do the cutting-edge cancer therapies being discussed by Avacta Group Plc AVCTF at AACR 2026 have for patient care in major cities like London and Philadelphia?
The cutting-edge cancer therapies presented by Avacta Group Plc at AACR 2026 could significantly enhance patient care in major cities like London and Philadelphia by introducing more effective treatments, improving survival rates, and potentially reducing healthcare costs through targeted therapies.
How might the advancements by Avacta Group Plc AVCTF affect the competitive landscape for biopharmaceutical firms based in London compared to those in Philadelphia?
The advancements by Avacta Group Plc (AVCTF) could potentially enhance the competitive edge of London-based biopharmaceutical firms by increasing innovation and attracting investment, while Philadelphia firms may need to innovate rapidly to maintain their market position in response.

**MWN-AI FAQ is based on asking OpenAI questions about Avacta Group Plc (OTC: AVCTF).

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