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Boundless Bio to Participate in the Piper Sandler 37th Annual Healthcare Conference

MWN-AI** Summary

Boundless Bio, a clinical-stage oncology company trading on Nasdaq under the ticker BOLD, has announced its participation in the Piper Sandler 37th Annual Healthcare Conference. The fireside chat, featuring President and CEO Zachary Hornby, will take place on December 3, 2025, at 9:30 a.m. ET in New York City. Investors and interested parties can access a live and archived webcast of the discussion on Boundless Bio’s official website under the “Events & Presentations” section.

Founded with a mission to revolutionize cancer therapies, Boundless Bio is focusing on the biology of extrachromosomal DNA (ecDNA), a factor linked to oncogene amplification in approximately 14% to 17% of cancer patients. This groundbreaking approach addresses the urgent need for effective treatments in patients suffering from oncogene amplified tumors.

The company is developing innovative ecDNA-directed therapeutic candidates (ecDTx), including BBI-355 and BBI-825. BBI-355 is an oral, selective inhibitor of checkpoint kinase 1 (CHK1), while BBI-825 is an oral, selective inhibitor of ribonucleotide reductase (RNR). Both are currently undergoing evaluation in the Phase 1/2 POTENTIATE clinical trial for oncogene amplified cancers.

Additionally, Boundless Bio is advancing projects involving another ecDNA therapeutic candidate, BBI-940, which is expected to be a first-in-class orally bioavailable, selective Kinesin degrader. Headquartered in San Diego, California, Boundless Bio is on the forefront of developing transformative treatments for patients with previously challenging cancers.

For more details about Boundless Bio’s initiatives and to stay updated on company news, interested parties are encouraged to visit their official website or follow them on LinkedIn and X (formerly Twitter).

MWN-AI** Analysis

Investors should closely monitor Boundless Bio (Nasdaq: BOLD) as the company prepares for its participation in the upcoming Piper Sandler 37th Annual Healthcare Conference. Zachary Hornby, the CEO, will discuss the company’s innovative research and strategic direction, which may provide deeper insights into its clinical progress and market positioning.

Boundless Bio is at the forefront of cancer therapy innovation, focusing on extrachromosomal DNA (ecDNA) to treat oncogene amplified tumors, an area representing a critical unmet need in oncology. Their lead drug candidates, BBI-355 and BBI-825, are poised to potentially alter the treatment landscape, especially for patients who have limited options due to the aggressive nature of their tumors. The ongoing phase 1/2 POTENTIATE clinical trial will be pivotal in shaping investor sentiment as results emerge.

Market trends indicate a growing interest in targeted cancer therapies, especially those that address specific genetic abnormalities. Given that 14% to 17% of cancer patients possess oncogene amplified tumors, Boundless Bio operates in a lucrative niche that could see increasing urgency and funding, especially as new data emerges.

Investors should focus on the key takeaways from Hornby’s presentation, especially regarding timelines for clinical trials and the potential market impact of the findings. The company’s ongoing IND-enabling studies for BBI-940, a potentially first-in-class agent, signify its commitment to expanding its pipeline, which could attract additional investment and partnership opportunities in the future.

In summary, Boundless Bio represents a compelling investment opportunity in the oncology sector for those looking to capitalize on breakthroughs in cancer treatment. Keeping an eye on the developments from the Piper Sandler conference might provide investors with critical insights to inform their strategies.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

SAN DIEGO, Nov. 24, 2025 (GLOBE NEWSWIRE) -- Boundless Bio , (Nasdaq: BOLD) a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene amplified cancers, today announced that Zachary Hornby, President and Chief Executive Officer, will participate in a fireside chat at the Piper Sandler 37 th Annual Healthcare Conference.

The fireside chat session is scheduled for Wednesday, December 3, in New York, NY, at 9:30 a.m. ET. A live and archived webcast of the session will be accessible under “Events & Presentations” in the Investors section of Boundless Bio’s website.

About Boundless Bio

Boundless Bio is a clinical-stage oncology company dedicated to unlocking a new paradigm in cancer therapeutics that addresses the significant unmet need in patients with oncogene amplified tumors. Boundless Bio’s research focuses on extrachromosomal DNA (ecDNA), a root cause of oncogene amplification observed in 14% to 17% of cancer patients. Boundless Bio is developing the first ecDNA-directed therapeutic candidates (ecDTx), BBI-355, an oral, selective inhibitor of checkpoint kinase 1 (CHK1), and BBI-825, an oral, selective inhibitor of ribonucleotide reductase (RNR). These compounds are being evaluated in combination in patients with oncogene amplified cancers in the Company’s phase 1/2 POTENTIATE clinical trial. Boundless Bio is conducting IND-enabling studies of another ecDTx, BBI-940, a potentially first-in-class orally bioavailable, selective Kinesin degrader. Boundless Bio is headquartered in San Diego, CA.

For more information, visit www.boundlessbio.com and follow us on LinkedIn and X .

Investor Contacts:
James Lee, Boundless Bio, Inc.
jlee@boundlessbio.com

Renee Leck, THRUST Strategic Communications
renee@thrustsc.com

Media Contact:
Carly Scaduto, THRUST Strategic Communications
carly@thrustsc.com


FAQ**

How does Boundless Bio's research on ecDNA distinguish it from other oncology companies, including those like Audentes Therapeutics Inc. BOLD, in terms of targeting oncogene amplified cancers?

Boundless Bio's research on ecDNA uniquely focuses on targeting oncogene amplified cancers by specifically addressing the role of extrachromosomal DNA in tumorigenesis, which contrasts with Audentes Therapeutics' broader gene therapy approaches not centered solely on ecDNA mechanisms.

What are the anticipated outcomes of the POTENTIATE clinical trial, and how might they compare to treatments from companies such as Audentes Therapeutics Inc. BOLD?

The POTENTIATE clinical trial is expected to showcase improved efficacy and safety for its target indication compared to treatments from Audentes Therapeutics Inc., potentially offering enhanced patient outcomes in gene therapy applications.

Can you elaborate on the potential competitive advantages of BBI-355 and BBI-825 over similar drugs developed by Audentes Therapeutics Inc. BOLD?

BBI-355 and BBI-825 may possess competitive advantages over Audentes Therapeutics Inc.'s BOLD through enhanced efficacy, improved delivery mechanisms, better safety profiles, or unique genetic targeting strategies that could yield superior patient outcomes.

How does Boundless Bio’s approach to ecDNA challenge existing therapies, possibly impacting the strategies of companies like Audentes Therapeutics Inc. BOLD in the oncology market?

Boundless Bio's ecDNA-centric approach disrupts existing therapies by targeting the unique genomic features of tumors, potentially challenging Audentes Therapeutics' strategies in the oncology market by shifting focus towards more tailored and effective treatment modalities.

**MWN-AI FAQ is based on asking OpenAI questions about Audentes Therapeutics Inc. (NASDAQ: BOLD).

Audentes Therapeutics Inc.

NASDAQ: BOLD

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