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Promino Nutritional Sciences Inc. Launches Second Preclinical Study Targeting Reduction of Muscle Loss in Breast and Prostate Cancer Patients Undergoing Chemotherapy

MWN-AI** Summary

Promino Nutritional Sciences Inc. has initiated its second preclinical study focused on reducing muscle loss in breast and prostate cancer patients undergoing chemotherapy. By examining the effects of its patented essential amino acid (EAA) blend, Promino aims to combat cachexia, a significant side effect that leads to severe muscle loss during treatment. This latest research, conducted on murine models, is spearheaded by Dr. Patrick Gunning, a prominent figure in medicinal chemistry, who serves as the Chief Scientific Advisor to Promino.

Breast and prostate cancers are the most common cancers, affecting over 2.3 million women and 1.4 million men globally each year. Despite improvements in cancer treatments, many patients experience a decline in muscle mass and physical function, adversely impacting their recovery and overall quality of life. Dr. Gunning emphasized the importance of this research in potentially enhancing treatment outcomes through targeted nutritional support.

Promino's EAA blend was developed by Dr. Robert Wolfe, a pioneer in muscle metabolism, to stimulate muscle protein synthesis, especially in patients facing the metabolic stress associated with cancer treatments. This new preclinical study is expected to lay the groundwork for future clinical trials and the creation of a dedicated line of products tailored specifically for oncology patients.

CEO Vito Sanzone stated that this marks a decisive moment for Promino, positioning the company at the crossroads of clinical nutrition and cancer care, with the goal of delivering precision nutritional therapy. The results from these studies are anticipated to guide further human trials and collaborations with leading oncology institutions in North America, enhancing the company's research pipeline and commitment to innovation in clinical nutrition.

MWN-AI** Analysis

Promino Nutritional Sciences Inc. (CSE: MUSL) has ventured into crucial preclinical studies aimed at alleviating muscle loss in breast and prostate cancer patients undergoing chemotherapy. Under the stewardship of Dr. Patrick Gunning, a luminary in medicinal chemistry, Promino's patented amino acid blend is positioned to address cachexia—an often-overlooked issue in cancer care. As the market for dietary supplements targeted toward medical use expands, this research could redefine approaches in oncology nutrition.

Promino’s target demographics—breast and prostate cancer patients—represent significant potential, with over 3.7 million new cases diagnosed globally each year. Their approach of integrating essential amino acids to bolster treatment tolerance and recovery aligns well with evolving healthcare trends favoring personalized medicine. Investors should consider the substantial unmet need for nutritional interventions that support cancer treatment, enhancing both recovery quality and patient outcomes.

The results from these studies could pave the way for further clinical trials, fortifying Promino's portfolio with evidence-based products tailored for oncology. The interest from leading research institutions can facilitate partnerships, potentially increasing market reach and credibility. Moreover, the growing awareness of the importance of nutrition in cancer care broadens the market potential for Promino’s products.

However, investors should approach with caution. The broad landscape of nutraceuticals can be competitive, and the successful navigation of regulatory hurdles is crucial for future growth. The preclinical outcomes will be pivotal; positive data could lead to significant stock appreciation, while any setbacks may dampen investor enthusiasm.

In conclusion, Promino stands at a transformative juncture, with the potential to carve a niche in oncology nutritional support. Investors should closely monitor study developments as a catalyst for stock movement and consider the implications of their findings for the nutraceutical market.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: Newsfile
  • Research to explore Promino's patented amino acid blend in addressing treatment-related muscle wasting in two of the most prevalent cancers among women and men
  • Study led by Dr. Patrick Gunning, Professor of Medicinal Chemistry and Molecular Therapeutics, University of Toronto and University of Glasgow

Burlington, Ontario--(Newsfile Corp. - April 14, 2025) - Promino Nutritional Sciences Inc. (CSE: MUSL) (OTC Pink: MUSLF) (FSE: 93X) (the "Company" or "Promino") is pleased to announce the launch of its second round of preclinical studies evaluating the effects of Promino, a patented essential amino acid (EAA) blend, on muscle preservation and systemic health during chemotherapy treatment for breast and prostate cancer - the most commonly diagnosed cancers in women and men, respectively.

The preclinical trials will be conducted using murine models and aim to provide critical insights into the role of Promino's clinically formulated EAA blend in counteracting the severe muscle loss (cachexia) often associated with chemotherapy. The studies are being led by Dr. Patrick Gunning, a globally recognized medicinal chemist and Chief Scientific Advisor to Promino.

Addressing a Widespread and Underserved Need in Oncology Support

Breast cancer affects more than 2.3 million women globally each year[1], while prostate cancer impacts over 1.4 million men annually[2]. Despite advances in oncology, many patients suffer significant declines in muscle mass and function during chemotherapy, impairing both treatment tolerance and recovery outcomes.

"These preclinical studies represent a critical step toward understanding how targeted amino acid formulations can support patients undergoing highly demanding chemotherapy protocols," said Dr. Patrick Gunning, Chief Scientific Advisor to Promino. "Preserving muscle mass and function is not only about quality of life, it may also influence treatment outcomes and recovery trajectories. We're excited to be advancing this vital research."

Rooted in Breakthrough Science by Leading Researchers

Promino's formulation was developed by Dr. Robert Wolfe of the University of Arkansas, leaders in amino acid science and pioneers in the study of muscle metabolism. Their patented EAA blend is optimized to stimulate muscle protein synthesis, even in the face of metabolic stress such as surgical recovery and extreme metabolic deficit.

Toward a Dedicated Oncology Line for Patients and Providers

This latest preclinical initiative will not only help inform Promino's future clinical roadmap but also support the development of a Promino line specifically tailored to oncology care with the goal of providing patients, healthcare systems, and medical professionals with targeted nutritional tools to help combat treatment-related muscle wasting.

"This is a landmark moment for Promino and the science behind our proprietary amino acid blend," said Vito Sanzone, CEO of Promino. "We are uniquely positioned to lead the intersection of clinical nutrition and cancer care. Our goal is to deliver Promino as a precision nutritional therapy that supports better treatment tolerance, faster recovery, and stronger quality of life."

Next Steps

The new preclinical studies follow encouraging initial data and are designed to meet rigorous scientific standards. Results will inform future human trials and potential clinical collaborations with leading oncology institutions in North America.

For more information on Promino's research pipeline and commitment to innovation in clinical nutrition, visit www.drinkpromino.com.

About Promino

Promino is an innovative and research driven Canadian nutraceutical company specializing in the development of patented and science-based products for the global consumer packaged goods market, with a portfolio focused specifically on muscle health. Promino's lead product, Rejuvenate Muscle™ Activator, is a patented proprietary formulation that is clinically proven to assist in the building, rebuilding, restoration and rejuvenation of natural muscle mass. Promino also offers Promino™, an elite performance supplement for both professional and amateur athletes to accelerate muscle recovery, build strength and accelerate recovery from injury. Promino was founded in 2015 and is located in Burlington, Ontario.

For more information about Rejuvenate Muscle™ Activator and where to purchase, visit www.rejuvenatemuscle.com.

Promino™ - NSF Certified for Sport® brand ambassadors include NHL Stanley Cup™ Champion Jack Eichel of the Vegas Golden Knights and MLB Legend and Toronto Blue Jays 6x All-Star José Bautista.

To learn more about Promino, visit www.drinkpromino.com.

Forward-Looking Statements

This news release contains "forward-looking information" and "forward-looking statements" (collectively, "forward-looking statements") within the meaning of applicable Canadian securities legislation. All statements, other than statements of historical fact, are forward-looking statements and are based on expectations, estimates and projections as at the date of this news release. All statements that address activities, events, or developments that the Company expects or anticipates will, or may, occur in the future, are forward-looking statements, including statements regarding the Company's business prospects, potential growth in the functional beverage market, future trends, plans and strategies. In some cases, forward looking statements are preceded by, followed by, or include words such as "may", "will," "would", "could", "should", "believes", "estimates", "projects", "potential", "expects", "plans", "anticipates", "continues", or the negative of those words or other similar or comparable words. In preparing the forward-looking statements in this news release, the Company has applied several material assumptions, including, but not limited to, that protein supplement market growth will continue as anticipated by the Company, and that general business and economic conditions will not change in a materially adverse manner. These forward-looking statements are based on reasonable assumptions and estimates of management of the Company at the time such statements were made. Actual future results may differ materially as forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of the Company to materially differ from any future results, performance or achievements expressed or implied by such forward-looking statements. Although the forward-looking statements contained in this news release are based upon what management of the Company believes, or believed at the time, to be reasonable assumptions, the Company cannot assure shareholders that actual results will be consistent with such forward-looking statements, as there may be other factors that cause results not to be as anticipated, estimated or intended. Readers should not place undue reliance on the forward-looking statements and information contained in this news release. The Company assumes no obligation to update the forward-looking statements of beliefs, opinions, projections, or other factors.

No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.

For further information about Promino:
Vito Sanzone, CEO, vsanzone@drinkpromino.com, 289-348-1970 ext. 222

Marc Charbin, Investor Relations, marc.charbin@loderockadvisors.com, 416-467-5229


[1] Current and future burden of breast cancer: Global statistics for 2020 and 2040 - PMC
[2] The Lancet Commission on prostate cancer: planning for the surge in cases - The Lancet

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/248388

FAQ**

How do the preclinical studies of Promino Nutritional Sciences Inc. MUSLF aim to quantify the effectiveness of the patented amino acid blend in preventing muscle wasting in patients undergoing chemotherapy for breast and prostate cancer?

The preclinical studies of Promino Nutritional Sciences Inc. MUSLF aim to quantify the effectiveness of their patented amino acid blend in preventing muscle wasting during chemotherapy by evaluating its impact on muscle mass retention and overall physical function in relevant animal models.

What specific mechanisms are being investigated in the murine models to determine how Promino Nutritional Sciences Inc. MUSLF's EAA blend impacts muscle protein synthesis during chemotherapy-induced metabolic stress?

Researchers are exploring the effects of Promino Nutritional Sciences Inc. MUSLF's EAA blend on muscle protein synthesis in murine models by investigating signaling pathways involved in mTOR activation, myofibrillar protein turnover, and the role of amino acids in anabolic responses during chemotherapy-induced metabolic stress.

What prior data has informed the design of these latest preclinical studies, and how do the initial findings guide the expectations for efficacy in the treatment of cachexia in breast and prostate cancer patients?

Prior research on cachexia's pathophysiology and treatment responses has shaped the design of these preclinical studies, suggesting that the initial findings may indicate improved efficacy in targeting metabolic and inflammatory pathways in breast and prostate cancer patients.

How does Promino Nutritional Sciences Inc. MUSLF plan to translate findings from these preclinical studies into clinical trials, and what potential partnerships are being explored with leading oncology institutions for future research?

Promino Nutritional Sciences Inc. (MUSLF) aims to transition findings from preclinical studies to clinical trials by leveraging collaborations with leading oncology institutions to establish partnerships that enhance research and development in innovative nutritional interventions for cancer care.

**MWN-AI FAQ is based on asking OpenAI questions about Promino Nutritional Sciences Inc. (OTC: MUSLF).

Promino Nutritional Sciences Inc.

NASDAQ: MUSLF

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Consumer Products - Foods
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