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OKYO Pharma to Present at the GPCRs-Targeted Drug Discovery Summit

MWN-AI** Summary

OKYO Pharma Limited (NASDAQ: OKYO), a clinical-stage biopharmaceutical company, is set to present at the 4th Annual GPCRs-Targeted Drug Discovery Summit in Boston, MA, on May 22, 2025. CEO Dr. Gary S. Jacob will lead an oral presentation focused on the company’s lead drug candidate, urcosimod, designed to treat neuropathic corneal pain (NCP), a severe and debilitating eye condition that currently lacks an FDA-approved treatment.

NCP is characterized by chronic pain and sensitivity in the eyes, face, or head, often resulting from nerve damage and inflammation. Current treatment options are limited and often administered off-label, highlighting the critical need for effective therapeutic solutions. Urcosimod (formerly OK-101) is a lipid-conjugated chemerin peptide agonist targeting the ChemR23 receptor, predominantly found on immune cells and neurons in the eye. This novel approach aims to reduce inflammation and alleviate pain by enhancing the residency of the drug in the ocular environment, achieved through a unique membrane-anchored-peptide technology.

In recent clinical studies, urcosimod demonstrated statistical significance in multiple endpoints during a 240-patient Phase 2 trial for dry eye disease. The company is currently assessing urcosimod's efficacy in a Phase 2 trial for neuropathic corneal pain, which recently concluded with 17 patients participating.

OKYO Pharma focuses on innovative therapies for ocular diseases and continues to explore the potential of urcosimod in addressing pressing medical needs. The upcoming presentation at the summit will provide insights into the company's advancements and the promising developments surrounding urcosimod, aimed at transforming treatment for NCP and contributing to the landscape of ocular medicine. For more information, visit www.okyopharma.com.

MWN-AI** Analysis

OKYO Pharma Limited (NASDAQ: OKYO) is poised for significant attention with its upcoming presentation at the 4th Annual GPCRs-Targeted Drug Discovery Summit on May 22, 2025. Given the continuing challenges in treating neuropathic corneal pain (NCP), which currently lacks an FDA-approved therapy, the company’s lead candidate, urcosimod, presents a compelling investment opportunity.

Urcosimod, a lipid-conjugated chemerin peptide agonist, is designed to address the inflammatory and pain aspects associated with NCP, leveraging innovative membrane-anchored peptide technology for enhanced ocular residence time. The recent positive outcomes from a Phase 2 trial for dry eye disease suggest a robust therapeutic profile, making it a potentially valuable treatment for both NCP and dry eye conditions.

As Dr. Gary S. Jacob, CEO, delivers insights into urcosimod’s clinical development, the market will be scrutinizing the implications of these results. Investors should consider both the market potential for a treatment in an unmet medical need and the risk profile of clinical-stage biopharmaceutical companies, especially those in the eye care sector.

With an increasing awareness of NCP's severe impacts, OKYO’s innovative approach could attract partnerships or acquisition interests from larger biopharmaceutical entities seeking to capitalize on niche markets. Additionally, the forthcoming presentation could serve as a catalyst for price momentum, especially if results from the recently completed Phase 2 trial are publicly detailed and supportive.

In summary, while OKYO represents a speculative investment reflective of early-stage biotech ventures, its unique positioning in the market for ocular disease therapies could yield substantial returns for investors following its clinical progress. Potential investors should monitor developments closely, as the upcoming summit will provide critical insights into the efficacy of urcosimod and its growth trajectory in this challenging landscape.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

LONDON and NEW YORK, May 19, 2025 (GLOBE NEWSWIRE) -- OKYO Pharma Limited (NASDAQ: OKYO), a clinical-stage biopharmaceutical company developing innovative therapies for the treatment of neuropathic corneal pain, a severe ocular condition without an FDA approved therapy, and for inflammatory eye diseases, announced that its CEO, Gary S. Jacob, Ph.D., will be giving an oral presentation at the 4 th Annual GPCRs-Targeted Drug Discovery Summit in Boston, MA on May 22, 2025. Dr. Jacob’s presentation will cover the development of urcosimod, OKYO’s lead clinical drug candidate, to treat neuropathic corneal pain (NCP) which is a debilitating condition affecting many tens of thousands worldwide, and is characterized by chronic, severe eye discomfort.

Presentation Information:

Event: 4th Annual GPCRs-Targeted Drug Discovery Summit

Presenter: Dr. Gary S. Jacob, CEO of OKYO Pharma

Presentation Title: Clinical Development of Urcosimod, Targeting CMKLR1 (ChemR23), to Treat Neuropathic Corneal Pain

Date: Thursday, May 22, 2025

Location: Revere Hotel Boston Common, Boston, MA

About Neuropathic Corneal Pain (NCP)
NCP is a condition that causes severe pain and sensitivity of the eyes, face, or head. The exact cause of NCP is unknown but is thought to result from nerve damage to the cornea combined with inflammation . NCP, which can exhibit as a severe, chronic, debilitating condition in patients suffering from a host of ophthalmic conditions, is presently treated, with limited success, by various topical and systemic treatments in an off-label fashion.

About Urcosimod (formerly called OK-101)
Urcosimod is a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor which is typically found on immune cells of the eye responsible for the inflammatory response, as well as on neurons and glial cells in the dorsal root ganglion. Urcosimod was developed using a membrane-anchored-peptide technology to produce a novel long-acting drug candidate for treating dry eye disease. Urcosimod has been shown to produce anti-inflammatory and pain-reducing activities in mouse models of dry eye disease and corneal neuropathic pain, respectively, and is designed to combat washout through the inclusion of the lipid anchor built into the drug molecule to potentially enhance the residence time of urcosimod within the ocular environment. Urcosimod showed clear statistical significance in multiple endpoints in a 240-patient Phase 2, multi-center, double-masked, placebo-controlled trial to treat dry eye disease, and is presently being evaluated in a just-completed randomized, placebo-controlled, double-masked Phase 2 trial involving 17 neuropathic corneal pain patients.

About OKYO
OKYO Pharma Limited (NASDAQ: OKYO) is a clinical stage biopharmaceutical company developing innovative therapies for the treatment of neuropathic corneal pain and dry eye disease, with ordinary shares listed for trading on the NASDAQ Capital Market. OKYO is focused on the discovery and development of novel molecules to treat neuropathic corneal pain and ocular diseases. In addition to the completed Phase 2 trial of urcosimod to treat dry eye disease patients, OKYO is also currently evaluating urcosimod to treat neuropathic corneal pain patients in a Phase 2 trial.

For further information, please visit www.okyopharma.com .

Enquiries:

OKYO Pharma Limited Gary S. Jacob, Chief Executive Officer 917-497-7560
Business Development & Investor Relations Paul Spencer +44 (0)20 7495 2379

FAQ**

How does OKYO Pharma Limited's innovative therapies differ from existing treatments for neuropathic corneal pain, and what potential does urcosimod have for patients in major markets like London and New York?

OKYO Pharma Limited's innovative therapies, particularly urcosimod, offer a novel approach to treating neuropathic corneal pain by targeting underlying inflammatory pathways, potentially providing improved efficacy and safety for patients in major markets like London and New York.

Given the global reach of OKYO Pharma Limited, what strategies will the company employ to promote awareness of neuropathic corneal pain treatment options in financial centers like London and New York?

OKYO Pharma Limited will leverage targeted marketing campaigns, collaborate with key opinion leaders in ophthalmology, engage in educational seminars, and utilize digital platforms to raise awareness of neuropathic corneal pain treatment options in financial hubs like London and New York.

How will the outcomes of the Phase 2 trials for urcosimod impact OKYO Pharma Limited's stock performance in key markets such as London and New York, considering investor anticipation around innovative therapies?

The outcomes of the Phase 2 trials for urcosimod are likely to significantly influence OKYO Pharma Limited's stock performance in London and New York by heightening investor anticipation for innovative therapies, potentially leading to increased market confidence and stock valuation.

What are the implications of Dr. Gary S. Jacob’s presentation at the GPCRs-Targeted Drug Discovery Summit for OKYO Pharma Limited’s future collaborations and partnerships in London and New York?

Dr. Gary S. Jacob's insights at the GPCRs-Targeted Drug Discovery Summit may enhance OKYO Pharma Limited's attractiveness for future collaborations and partnerships in London and New York by showcasing its innovative approaches and potential for transformative drug development.

**MWN-AI FAQ is based on asking OpenAI questions about OKYO Pharma Limited (NASDAQ: OKYO).

OKYO Pharma Limited

NASDAQ: OKYO

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