Never Mind the Cloudflare System Issues, Here's the Morning Market Update

2025-11-18 09:50:31 ET

DENVER, Colo., Nov 18, 2025 ( 247marketnews.com )- Roche Group’s (OTCQX:RHHBY) Genentech, reported positive Phase III results from the lidERA Breast Cancer study evaluating investigational giredestrant as an adjuvant endocrine treatment for people with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, early-stage breast cancer.

The study met its primary endpoint and demonstrated a statistically significant, and clinically meaningful improvement, in invasive disease-free survival with giredestrant versus standard-of-care endocrine therapy. lidERA is the first Phase III trial of a selective estrogen receptor degrader (SERD) to demonstrate a significant benefit in the adjuvant setting. The majority of breast cancer cases are diagnosed at an early stage.

Levi Garraway, M.D., Ph.D., Genentech’s chief medical officer and head of Global Product Development, said, “Given that ER-positive breast cancer accounts for approximately 70% of cases diagnosed, these findings – together with recent data in the advanced ER-positive setting – suggest that giredestrant has the potential to improve outcomes for many people with this disease.”

However, the bigger winner from Genentech’s news is Olema Pharmaceuticals (NASDAQ:OLMA), which is advancing its lead asset palazestrant, a comprehensive estrogen receptor antagonist (CERAN) and a SERD, in multiple breast cancer clinical studies with Novartis (NYSE:NVS) and Pfizer (NYSE:PFE).

Kraig Biocraft Laboratories (OTCQB:KBLB) announced a major milestone in the commercialization of its recombinant spider silk platform, confirming that it is now fulfilling an order for customized spider silk yarns from a globally recognized performance sports apparel brand, as part of a confidential pilot development program to create a special product, which is under strict confidentiality until the sports apparel brand releases it.

This order marks one of the most significant commercialization steps in the Company’s history and a major milestone long anticipated by many shareholders, as Kraig Labs begins delivering spider silk super fibers engineered for elite-tier athletic applications. The collaboration validates the company’s position as the first and only commercial entity to demonstrate scalable high-performance recombinant spider silk production using traditional sericulture methods.

Kraig Labs is currently processing a portion of its next-generation spider silk inventory into purpose-built, customer-specified yarns, which are expected to ship before the end of the first quarter. These materials will be used by the customer’s engineering team in a cutting-edge, high-performance application known for its demanding technical requirements.

While details of the initiative remain protected under confidentiality restrictions, the Company confirmed that the application is positioned at the highest tier of the global performance apparel market, where durability, tensile strength, elasticity, and weight-to-performance ratios are critical. Spider silk has long been viewed as the “holy grail” of textile materials due to its unique combination of properties, qualities that have inspired billions of dollars in global R&D attempts by synthetic biology giants, Fortune 500 apparel brands, leading chemical companies, and government-funded laboratories. Despite this, Kraig Labs stands alone in having achieved multiple “firsts” in the commercialization, scalability, and real-world deployment of recombinant spider silk.

This order comes on the heels of Kraig’s recent announcement of the production of specialty fibers intended for a globally recognized European Fashion house, which is still ongoing.  Kraig has recently expanded its production footprint by opening up several facilities across Southeast Asia. Additional orders should be expected as the company continues to scale its production capabilities, and fulfills existing obligations

Kraig Labs’ hybrid approach, merging molecular genetics with traditional sericulture, has made it the first company to demonstrate repeatable, industrially scalable production of recombinant spider silk. This technology could unlock not only advanced apparel applications, but also next-generation materials for:

• Technical textiles
• Defense and ballistic protection
• Performance gear
• Medical devices
• Industrial-strength composites

“This collaboration underscores the growing recognition of our material’s potential in high-value, high-performance applications,” said Kim Thompson, Kraig Labs’ Founder and CEO. “We are excited to support this project and a customer whose commitment to innovation aligns with our own. We look forward to showcasing what our spider silk can deliver at the elite level of apparel design and performance.”

Gorilla Technology (NASDAQ:GRRR) reported its third quarter financial results, reiterated its fiscal 2025 guidance, and provided guidance for full year 2026.

Q3 revenue was $26.5 million, about 32% high than the $20.1 million for the same period in 2024. The increase was due primarily to Gorilla’s execution on AI infrastructure, public safety and enterprise projects across Asia, the Middle East, Europe and the Americas.

Gorilla also delivered EBITDA of $0.8 million for the third quarter, compared to an EBITDA loss of $5.6 million for the third quarter of 2024.

Jay Chandan, Chairman and CEO, stated, “The third quarter marks a turning point where Gorilla became a recognized leader in AI infrastructure. Our contracted projects, strong balance sheet and clear line of sight to scale differentiate us from peers that have yet to deliver beyond the promise of AI. We are optimistic about our revenue growth in the coming years, driven by secured mandates, including our recently announced $1.4 billion AI data centre contract in Southeast Asia, as well as ongoing deployments and a robust pipeline.”

Onfolio Holdings (NASDAQ:ONFO) secured up to $300 million in financing through a convertible note facility, with the first $6 million tranche closing today. The funds strengthen Onfolio’s financial position and support its next phase of expansion

Dom Wells, Onfolio’s CEO, commented, “We’ve structured this facility to allow us to invest directly in Bitcoin, Ethereum, and Solana, and stake those assets through established digital finance platforms to earn a return on invested capital, while also adding meaningful cash to support our operations and our path toward sustained profitability.

“We see the initial tranches as transformative for Onfolio, and believe that future tranches, if drawn, would meaningfully expand our strategic flexibility and support the continued scaling of our business.”

For more information about Kraig Labs’ spider silk technology and partnership opportunities, visit www.kraiglabs.com

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Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements that are subject to various risks and uncertainties. Such statements include statements regarding the Company’s ability to grow its business and other statements that are not historical facts, including statements which may be accompanied by the words “intends,” “may,” “will,” “plans,” “expects,” “anticipates,” “projects,” “predicts,” “estimates,” “aims,” “believes,” “hopes,” “potential” or similar words. Actual results could differ materially from those described in these forward-looking statements due to a number of factors, including without limitation, the Company’s ability to continue as a going concern, general economic conditions, and other risk factors detailed in the Company’s filings with the SEC. The forward-looking statements contained in this press release are made as of the date of this press release, and the Company does not undertake any responsibility to update such forward-looking statements except in accordance with applicable law.

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