LIFE - aTyr Pharma to Present Poster Describing Efzofitimod's Mechanism of Action at the American Thoracic Society 2024 International Conference | Benzinga
SAN DIEGO, May 15, 2024 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (NASDAQ:LIFE) (aTyr or the "Company"), a clinical stage biotechnology company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced that the company will present data for its lead therapeutic candidate, efzofitimod, at the American Thoracic Society (ATS) 2024 International Conference, which is scheduled to take place May 17 – 22 in San Diego, CA.
"These findings further demonstrate the unique way in which efzofitimod is modulating myeloid cells to confer the anti-inflammatory benefits we have seen in patients with pulmonary sarcoidosis, a major form of interstitial lung disease (ILD)," said Sanjay S. Shukla, M.D., M.S., President and Chief Executive Officer of aTyr. "With an enhanced understanding of efzofitimod's novel mechanism we have greater confidence in the potential for this first-in-class immunomodulator to be a transformative treatment for ILD, including pulmonary sarcoidosis, where we are currently conducting a pivotal Phase 3 study."
Details of the presentation appears below. The poster will be available on the aTyr website once presented.
Title: Efzofitimod is an Immunomodulator of Myeloid Cell Function and Novel Therapeutic Candidate for Interstitial Lung Diseases
Session Title: Evaluating the Intersection Between Autoimmunity, Immunodeficiency, and Interstitial Lung Diseases
Session Format: Poster Discussion Session
Poster Number: 8837
Date and Time: Sunday, May 19, 2024, from 2:15 p.m. to 4:15 p.m.
Location: Room 31A-C (Upper Level), San Diego Convention Center
The poster presents findings demonstrating that by selectively binding neuropilin-2 (NRP2), a cell surface receptor upregulated at active sites of inflammation, most notably on myeloid cells, efzofitimod modulates the differentiation of monocyte-derived macrophages in healthy donors and ILD patients, resulting in a unique phenotype with reduced inflammatory potential. Additionally, the data further validates the discovery of NRP2 as an important new immune target, with higher expression of NRP2 detected on circulating monocytes from ILD patients compared to healthy donors and on macrophages within pulmonary sarcoidosis granulomas ...