FBIO - Avenue Therapeutics to Present at American Epilepsy Society 2023 Annual Meeting | Benzinga
MIAMI, Dec. 01, 2023 (GLOBE NEWSWIRE) -- Avenue Therapeutics, Inc. (NASDAQ:ATXI) ("Avenue" or the "Company"), a specialty pharmaceutical company focused on the development and commercialization of therapies for the treatment of neurologic diseases, today announced that Amy Chappell, M.D., FAAN, will be presenting preclinical in vivo data evaluating BAER-101 using the SynapCell's Genetic Absence Epilepsy Rat from Strasbourg ("GAERS") model of absence epilepsy at the American Epilepsy Society (AES) 2023 Annual Meeting in Orlando, FL on December 2, 2023.
The Company's presentation details are as follows:
Title: A Phase 2- Ready Potentiator of ?2/3-Containing GABAA Receptors Potently and Fully Blocks Seizures in Rats with Genetic Absence Epilepsy
Poster Session and Location: Session 1; West Hall C, Level 2
Session Date/Time: Saturday, December 2, 2023, 12:00 p.m. ET
Board Number: 1.444
"We are pleased with the progress made with BAER-101, a molecule with unique pharmacology which has demonstrated that it can significantly suppress seizures in a translational animal model of absence epilepsy," said Alexandra MacLean, M.D., Chief Executive Officer of Avenue. "The presentation of preclinical results from this trial showcase BAER-101's selectively targeting of GABAA ?2 and ?3 subtypes more than ?1 and ?5, potentially improving anticonvulsant and anxiolytic activity while minimizing the risk of tolerance and abuse associated with existing treatments in this drug class. With these compelling preclinical results in-hand, along with the drug's proven safety profile in numerous clinical trials, we are encouraged by BAER-101's potential to address the unmet needs of epilepsy patients."
BAER-101 underwent preclinical in vivo evaluation in SynapCell's Genetic Absence Epilepsy Rat from Strasbourg ("GAERS") model of absence epilepsy. The GAERS model, which is a proven, early, informative indicator of efficacy in anti-seizure drug development with high predictability of response in humans, mimics behavioral, electrophysiological and pharmacological features of human absence seizures. In the model, BAER-101 demonstrated full suppression of seizure activity with a minimal effective dose of 0.3 mg/kg, PO. The effect was fast in onset and stable throughout the duration of testing. The combination of safety and tolerability in hundreds of patients and the preclinical efficacy data support BAER-101's ...