PFE - Cardiff: A Long-Term Biotech To Own Based On Overcoming Cancer Resistance
- Cardiff has done well in a Phase 2 study using onvansertib + FOLFIRI + Avastin in treating KRAS-mutated metastatic colorectal cancer patients with a 29% objective response rate.
- The global market opportunity for colorectal cancer is expected to reach $17.8 billion by 2026. About 50% of colorectal cancer population has KRAS mutation.
- Two other indications being targeted with onvansertib are metastatic pancreatic ductal cancer and Zytiga-resistant metastatic castration-resistant prostate cancer.
- Onvansertib has great potential because, in preclinical studies, it has shown to synergize well with 12+ targeted/chemotherapies.
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Cardiff: A Long-Term Biotech To Own Based On Overcoming Cancer Resistance