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Duquesne adds Nuance (NUAN) with a 2.9M-share holding, Cloudflare with a ~257K holding and Carvana (CVNA) with a ~92K-share stake, according to its 13F filing.Exits Carmax (KMX), DraftKings (DKNG), and Wells Fargo (WFC).Increases stake in Microsoft (MSFT) to ~2.65M shares from ~1.80M shares.Reduces PayPal (PYPL) stake to 141K shares from ~769K shares.