KNTE - Kinnate Biopharma begins dosing in phase 1 trial of KIN-3248 in advanced tumors
Kinnate Biopharma (NASDAQ:KNTE) said the first patient began treatment in a phase 1 trial of KIN-3248 in adults with advanced tumors harboring FGFR2 and/or FGFR3 gene alterations. The company is exploring KIN-3248 as a next-generation pan-FGFR inhibitor for treating intrahepatic cholangiocarcinoma (ICC) (bile-duct cancer) and urothelial carcinoma (UC) (bladder cancer), and other solid tumors. The phase 1 trial, dubbed KN-4802, is a two-part study in ~120 patients. The dose expansion phase (Part B) will evaluate KIN-3248 at recommended dose in FGFR inhibitor naïve and FGFR inhibitor pretreated patients with cancers driven by FGFR2 and/or FGFR3 gene alterations, including ICC, UC and other selected adult solid tumors.
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Kinnate Biopharma begins dosing in phase 1 trial of KIN-3248 in advanced tumors