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The most natural explanation for the decline in real interest rates, then, is that growth has declined.
Potential GDP grew 4.5% in the 1960s, 3% in the 1970s, had a spurt in the late 1990s, and then settled down to less than 2% now. This slowdown in long-term growth is the great and unheralded economic disaster of our time.
As Olivier pointed out, there is no magic debt/GDP ratio dividing safe from dangerous. Debt crises have happened with 50% debt/GDP.