MGNX - Zai Lab commences study in China testing margetuximab in stomach cancer
The first patient has been dosed in a China-based Phase 2/3 study, MAHOGANY, evaluating Zai Lab's (ZLAB) margetuximab, combined with a checkpoint inhibitor, with or without chemo, for the first-line treatment of HER2-positive gastric cancer or gastroesophageal junction cancer.The PD-1 inhibitor will be either retifanlimab or tebotelimab, both developed by MacroGenics (MGNX).Margetuximab is an HER2-targeting monoclonal antibody. The company has exclusive development and commercialization rights in Greater China (also includes tebotelimab) under a 2018 agreement with MacroGenics.
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Zai Lab commences study in China testing margetuximab in stomach cancer