MINNEAPOLIS, Dec. 01, 2023 (GLOBE NEWSWIRE) -- Celcuity Inc. (NASDAQ:CELC), a clinical-stage biotechnology company pursuing development of targeted therapies for oncology, today announced that an abstract accepted for a poster presentation at the 2023 San Antonio Breast Cancer Symposium (SABCS) is now available on the SABCS website. The 2023 San Antonio Breast Cancer Symposium (SABCS) is being held virtually and in-person from December 5-9, 2023.
The presentation will include potency and efficacy data evaluating the effects of gedatolisib, a pan-PI3K/mTOR (PAM) inhibitor, and approved PAM inhibitors (PAMi) on breast cancer cell lines with mutated or non-mutated PAM pathway genes. Compared to the other PAMi, gedatolisib exhibited more potent and efficacious anti-proliferative and cytotoxic effects, regardless of the cell lines' PI3K pathway mutational status. Mechanistically, gedatolisib decreased both DNA and protein synthesis more effectively than the other PAMi tested.
These findings demonstrate that gedatolisib may more effectively address potential drug resistance mechanisms associated with the approved PAM inhibitors. A Phase 3 VIKTORIA-1 trial evaluating gedatolisib plus fulvestrant with and without palbociclib is underway in in adults with HR+, HER2- advanced breast cancer.
Poster presentation details are provided below.
Poster Title: "Gedatolisib, a pan-PI3K inhibitor shows superior potency & efficacy relative to other PI3K/AKT/mTOR pathway inhibitors in breast cancer models"
Author: Rossetti S et al.
Poster ID: PO1-24-04
Poster ...