10 Biggest Cannabis Stocks in the US and Canada

2025-07-22 16:15:00 ET

The cannabis market has faced unexpected challenges in 2025, despite initial optimism for rescheduling in the US.

While US federal regulatory uncertainty and banking remain persistent, companies are shifting focus to match changes in consumer behavior. The growing popularity of edibles and rising interest in cannabis-infused beverages reflect evolving demand in a persevering industry.

Cannabis companies in the sector continue to move forward and develop their offerings, and with potential catalysts ahead, some investors are interested in getting involved. Looking at the key players is often a good place to get started, so this list of US and Canadian cannabis stocks covers the companies with the largest presence in two major cannabis ETFs.

This list of the biggest publicly traded cannabis companies was put together based on the top-weighted cannabis stocks included in the AdvisorShares Pure US Cannabis ETF (ARCA: MSOS ) and the Horizons Marijuana Life Sciences Index ETF (TSX: HMMJ ) as of July 16, 2025. Share price information for the companies was accurate as of that time.

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