- Central to Cassava’s hypothesis requires amyloid beta-42 to induce an altered conformation of structural protein filamin A and that sumifilam restores altered filmin A back to its native state.
- Researchers have demonstrated that mutations that cause familial AD, amyloid beta-40, and -42 production is more likely to be reduced or abolished due to decreased enzymatic activity of gamma-secretase.
- Since amyloid beta-42 is reduced or abolished in familial AD, that suggests amyloid beta-42 may not be a causal factor in late onset AD.
- If the bullet point above correct, Cassava’s hypothesis that amyloid beta-42 induces conformational changes is false and sumifilam is likely to fail.
For further details see:
Cassava Sciences' Hypothesis Raises Doubts