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Creative Medical Technology Holdings Receives Notice of Allowance for the Prevention and/or Treatment of Type 1 Diabetes Using Modulated Immune Cells

MWN-AI** Summary

Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ) has announced a significant milestone with the receipt of a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for a patent titled “Prevention and/or Treatment of Type 1 Diabetes by Augmentation of Myeloid Suppressor Cell Activity.” This patent, once granted, will be valid until at least 2040, safeguarding the integrities of Creative Medical’s intellectual property portfolio.

The patent covers a novel cell-based immunotherapy method for treating Type 1 diabetes, utilizing the company’s ImmCelz™ product, which involves supercharging a patient’s own T regulatory cells using proprietary cell-free solutions. This therapeutic approach has been validated through patient-derived cells, aiming to address the autoimmune destruction of insulin-producing beta cells that characterizes Type 1 diabetes.

Timothy Warbington, CEO of Creative Medical, emphasized the importance of incorporating regenerative immunotherapy to tackle Type 1 diabetes, asserting that regenerative therapies align with the company's mission to meet significant medical needs. The ImmCelz™ platform reprograms a patient’s extracted immune cells, enhancing their function before reinjection back into the patient, thereby equipping these immune cells with regenerative properties for multiple medical conditions.

Creative Medical Technology Holdings focuses on pioneering regenerative medicine solutions, with ongoing endeavors including the CREATE-1 clinical trial, which further explores the treatment of Type 1 diabetes. As a clinical-stage biotechnology firm, the company is committed to leveraging innovative cell therapy technologies to develop transformative solutions across various medical sectors, including pain management, neurology, and urology. For more information, interested parties can visit the company's website.

MWN-AI** Analysis

Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ) recently announced receiving a Notice of Allowance from the USPTO for a patent relating to its ImmCelz platform for the treatment of Type 1 diabetes. This announcement signifies a crucial advancement in the company’s efforts to commercialize innovative regenerative therapies, placing it in an advantageous position within the biotechnology space.

The issuance of this patent provides a strategic competitive edge, potentially extending its intellectual property protection until at least 2040. Such a long-term patent could deter competitors and attract partnerships or investments, crucial in the biotechnology sector where funding is significant. Investors should note that Type 1 diabetes remains a substantial unmet medical need, with treatment options limited, making Creative Medical's advancements particularly promising.

The ImmCelz platform’s promise—a patient-centric approach involving reprogrammed immune cells—represents what many analysts consider a cutting-edge development in cellular immunotherapy. As the company continues to validate this approach through its ongoing CREATE-1 clinical trial, successful results could not only propel the stock price upwards but also enhance the company’s credibility within the regenerative medicine field.

From a market perspective, CELZ appears to be positioned for potential growth. For investors, it may be prudent to acquire shares, particularly in light of the excitement surrounding innovative therapeutics in the diabetes space. However, considerations regarding volatility inherent in clinical-stage biotechnology stocks should remain on the radar.

Investors should perform due diligence, considering the inherent risks and uncertainties associated with biotechnology ventures. Monitoring further developments in the clinical trials and overall market reactions will be key in assessing the long-term viability of Creative Medical Technology Holdings' investments.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

PHOENIX, July 17, 2025 (GLOBE NEWSWIRE) -- Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ) (“Creative Medical” or the “Company”) , a clinical-stage biotechnology company specializing in regenerative medicine, today announced that it has received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for a U.S. patent application titled, “ Prevention and/or Treatment of Type 1 Diabetes by Augmentation of Myeloid Suppressor Cell Activity .”

Once granted, the patent will be in effect until at least 2040.

The patent allows a broad cell-based immunotherapy approach to treating Type 1 diabetes using the ImmCelz TM product, which includes the supercharged T regulatory cells using the Company’s proprietary cell-free solutions. This program has been validated using cells from patients with Type 1 Diabetes.

Type 1 Diabetes is an autoimmune disease in which the body's immune system attacks and destroys insulin-producing beta cells in the pancreas.  Because beta cells produce insulin, which is essential for moving glucose (sugar) from the blood into cells for energy, the destruction of these cells leads to a deficiency in insulin and the development of diabetes.

"We believe that the use of ImmCelz to prevent and/or treat Type 1 Diabetes is regenerative immunotherapy in its truest form,” said Timothy Warbington, CEO of Creative Medical. “The treatment of Type 1 Diabetes remains a primary focus for our Company, as evidenced by our ongoing CREATE-1 clinical trial. This issuance protects the integrity of our IP portfolio and reflects the potential of our cell-based therapeutic platform to address multiple unmet medical needs.”

About ImmCelz TM
Creative Medical’s ImmCelz platform utilizes a patient’s own extracted immune cells that are then “reprogrammed/supercharged” by culturing them outside the patient’s body with optimized cell-free factors.  The immune cells are then re-injected into the patient from whom they were extracted. The Company believes that this process endows the immune cells with regenerative properties (or “supercharges” them) on top of their original innate functions providing them with the ability to treat multiple indications.

About Creative Medical Technology Holdings
Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ) is a clinical-stage biotechnology company pioneering regenerative medicine solutions for multiple indications, including pain management, neurology, and urology. The company leverages cutting-edge cell therapy technologies to develop transformative treatments aimed at improving patient outcomes.

For more information, visit www.creativemedicaltechnology.com .

Forward Looking Statements
This news release may contain forward-looking statements including, but not limited to, comments regarding the potential for the Company’s cell-based therapies and the strength of its intellectual property portfolio. Forward-looking statements address future events and conditions and, therefore, involve inherent risks and uncertainties. Actual results may differ materially from those currently anticipated in such statements. See the periodic and other reports filed by Creative Medical Technology Holdings, Inc. with the Securities and Exchange Commission and available on the Commission's website at www.sec.gov.

Contact:
Creative Medical Technology Holdings, Inc.
IR@CreativeMedicalTechnology.com

Investor Relations:
Devin Sullivan, Managing Director
The Equity Group Inc.
dsullivan@equityny.com

Conor Rodriguez
Associate
crodriguez@equityny.com


FAQ**

How does the recent patent allowance for Creative Medical Technology Holdings Inc. (CELZ) enhance the company's competitive position in the regenerative medicine market for Type 1 Diabetes?

The recent patent allowance for Creative Medical Technology Holdings Inc. (CELZ) strengthens the company's competitive position in the regenerative medicine market for Type 1 Diabetes by providing exclusive rights to innovative treatment methodologies, potentially enhancing product differentiation and market share.

What are the expected timelines for the ongoing CREATE-1 clinical trial and its potential implications for Creative Medical Technology Holdings Inc. (CELZ) in terms of market entry?

The CREATE-1 clinical trial is anticipated to progress through its phases over the next few years, with successful results potentially facilitating Creative Medical Technology Holdings Inc. (CELZ) market entry by showcasing the efficacy of its innovative treatments.

Can you elaborate on how Creative Medical Technology Holdings Inc. (CELZ)'s ImmCelz platform differs from traditional treatments for Type 1 Diabetes and its regenerative properties?

Creative Medical Technology Holdings Inc.'s ImmCelz platform differs from traditional Type 1 Diabetes treatments by utilizing regenerative cell therapy to potentially restore insulin production through the infusion of specialized stem cells, rather than merely managing symptoms.

What measures is Creative Medical Technology Holdings Inc. (CELZ) implementing to safeguard its intellectual property portfolio in the competitive biotechnology landscape?

Creative Medical Technology Holdings Inc. (CELZ) is safeguarding its intellectual property portfolio through a combination of robust patent filings, strategic partnerships, and ongoing legal enforcement to protect its innovations in the competitive biotechnology landscape.

**MWN-AI FAQ is based on asking OpenAI questions about Creative Medical Technology Holdings Inc. (NASDAQ: CELZ).

Creative Medical Technology Holdings Inc.

NASDAQ: CELZ

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