Dow and S&P 500 futures declined on Tuesday morning after the two major market benchmarks closed at record levels.
Futures for the Dow Jones Industrials shed 201 points, or 0.7%, to 29,664.
Futures for the S&P 500 slumped 21.25 points, or 0.6%, at 3,601.75.
Futures for the NASDAQ Composite 32.35 points, or 0.3%, to 12,037.25.
Shares of pharmacy owner CVS Health and Dow member Walgreens Boots Alliance dropped in pre-market trading after Amazon launched a pharmacy business, which allows free delivery of medications for Prime members.
Walgreens shares dropped 10% and CVS lost 6%. Amazon shares popped 2.6% in pre-market trading.
Tesla shares jumped more than 13% in pre-market trading after S&P Dow Jones Indices said the electric car maker would join the S&P 500 index, effective Dec. 21. It was a long anticipated move for the surging stock. Before Monday, the shares had already more than quadrupled this year.
Home Depot fell after its earnings report Monday morning even after saying sales surged 24% last quarter.
Walmart shares gained 2% in pre-market trading after earnings topped expectations on soaring e-commerce sales.
Pfizer and BioNTech said Nov. 9 that their Covid-19 vaccine candidate was more than 90% effective among participants in a late-stage trial.
Overseas, in Japan, the Nikkei 225 index gained 0.4% Tuesday, while in Hong Kong, the Hang Seng index eked up 0.1%.
Oil prices dropped 44 cents to $40.90 U.S. a barrel.
Gold prices inched forward 40 cents to $1,888.30 U.S.