Moderna Stock ( NASDAQ:MRNA )
Merck ( NYSE:MRK ) and Moderna ( NASDAQ:MRNA ) announced that their mRNA cancer vaccine, mRNA-4157/V940, in combination with Keytruda, achieved the primary objective of a phase 2b trial in select patients with melanoma. Melanoma is a kind of skin cancer.
When compared to Keytruda on its own as an adjuvant treatment for patients with stage 3/4 melanoma following complete resection, the personalized cancer vaccine mRNA-4157/V940 demonstrated a statistically significant and clinically meaningful improvement in the primary goal of recurrence-free survival (RFS).
In the research trial KEYNOTE-942, the pharmaceutical firms claimed that the combination reduced the risk of recurrence or mortality by 44% compared to Keytruda alone.
According to Stéphane Bancel, CEO of Moderna, “mRNA has proven revolutionary for COVID-19, and now, for the first time, we have proved the potential for mRNA to influence outcomes in a randomized clinical trial in melanoma.”
14.4% of patients who got the combination of mRNA-4157/V940 and Keytruda had serious treatment-related side events, compared to 10% of patients who received Keytruda on its own.
According to the businesses, the adverse events detected with mRNA-4157/V940 were comparable to those found in trials that had been previously published.
The businesses intend to discuss the findings with regulatory authorities, begin phase 3 research in patients with melanoma in 2023, and then extend to include people with othe...
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