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Labcorp® Plasma Detect(TM) Clinical Studies Featured in Nature Medicine and Clinical Cancer Research

MWN-AI** Summary

Labcorp® recently showcased its Plasma Detect™ technology, a cutting-edge blood-based assay designed for detecting molecular residual disease (MRD) through circulating tumor DNA (ctDNA), in two influential peer-reviewed journals: *Nature Medicine* and *Clinical Cancer Research*. These studies highlight the assay's significant role in informing treatment strategies and advancing cancer research.

One notable study featured in *Nature Medicine* addressed diffuse pleural mesothelioma (DPM), an aggressive and rare cancer often associated with asbestos exposure. The research examined two immune-based regimens administered pre-surgery, both of which were found to be safe and allowed the majority of patients to move forward with surgical treatment. Furthermore, the study indicated that those receiving neoadjuvant dual immune checkpoint blockade displayed promising signs of sustained clinical responses. Labcorp Plasma Detect played a crucial role in monitoring early disease progression and predicting long-term outcomes, suggesting a potential pathway for enhancing treatment approaches using ctDNA insights.

In another study reported in *Clinical Cancer Research*, findings highlighted the effectiveness of analyzing lymph fluid collected from surgical drains for head and neck cancer patients. This method yielded higher levels of tumor DNA compared to traditional blood samples taken post-surgery. Researchers demonstrated that Labcorp Plasma Detect could effectively identify residual cancer in these patients, particularly those at risk for locoregional recurrence. This advancement could lead to more timely and accurate decisions on follow-up treatments, significantly benefiting patients with HPV-independent head and neck cancers.

Shakti Ramkissoon, M.D., Ph.D., MBA, of Labcorp, emphasized the importance of these studies in showcasing the technology’s ability to advance cancer treatment insights and improve patient outcomes. For more details on Labcorp’s MRD offerings, visit their official website.

MWN-AI** Analysis

Labcorp (NYSE: LH) has recently garnered attention following the publication of its Plasma Detect™ technology in prestigious medical journals, highlighting its importance in the field of oncology. This blood-based assay, designed to detect molecular residual disease (MRD) from circulating tumor DNA (ctDNA), has demonstrated promising results in two critical studies, adding substantial value to the company’s market position.

The study highlighted in *Nature Medicine* focused on diffuse pleural mesothelioma (DPM), showing that Labcorp Plasma Detect effectively tracks disease progression and predicts long-term survival in patients undergoing innovative immunotherapy. This suggests that Labcorp's technology could play a pivotal role in personalizing cancer treatment strategies and driving patient outcomes, aligning with an increasing industry shift towards precision medicine.

Moreover, the findings reported in *Clinical Cancer Research* indicated that utilizing lymph fluid for testing post-surgery could outperform traditional methods in identifying residual cancer, particularly in head and neck cancers. This development not only underscores Plasma Detect's versatility but also highlights an opportunity for Labcorp to integrate these findings into clinical practice, potentially leading to expanded market share in oncology diagnostics.

Investors should consider the implications of these advancements. As hospitals and clinicians increasingly embrace advanced diagnostic tools in cancer treatment paths, Labcorp's investment in innovative technologies positions it favorably against competitors. Furthermore, the company’s established reputation and large-scale operations support its ability to rapidly adopt and disseminate these findings.

As a market analyst, I recommend closely monitoring Labcorp's stock performance, along with developments in the oncology sphere. The successful application of Plasma Detect could drive substantial revenue growth, making Labcorp a strong candidate for investment, particularly as the demand for personalized cancer therapies continues to escalate.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: PR Newswire

PR Newswire

Studies demonstrate Labcorp Plasma Detect MRD Technology can inform treatment strategies and advance cancer research

BURLINGTON, N.C., Nov. 19, 2025 /PRNewswire/ -- Labcorp (NYSE: LH), a global leader of innovative and comprehensive laboratory services, today announced Labcorp Plasma Detect, a tumor-informed, blood-based assay used to detect molecular residual disease (MRD) from circulating tumor DNA (ctDNA), was featured in two recent peer-reviewed publications – Nature Medicine and Clinical Cancer Research.

New Study Offers Hope for Rare and Aggressive Cancer
A study published in Nature Medicine provides encouraging results for patients with diffuse pleural mesothelioma (DPM), a rare and deadly cancer often linked to asbestos exposure. Researchers evaluated two immune-based treatment regimens given before surgery. Both approaches proved safe and enabled most patients to proceed with surgery. Notably, patients receiving neoadjuvant dual immune checkpoint blockade showed signals of durable clinical response. The study also demonstrated that Labcorp Plasma Detect can track early disease progression and predict long-term, progression-free survival. These findings suggest that perioperative immunotherapy combined with ctDNA monitoring may help shape new, more effective treatment strategies.

Post-Surgical Monitoring Breakthrough in Head and Neck Cancer
A study published in Clinical Cancer Research found that fluid collected from surgical drains after head and neck cancer surgery contains more tumor DNA than peripheral blood samples taken at the same time. Using Labcorp Plasma Detect, researchers compared lymph fluid to plasma collected 24 hours post-surgery and confirmed that lymph-based testing effectively identified residual cancer, particularly in patients with locoregional recurrence, signaling risk in patients who might otherwise go undetected by traditional pathology methods. These findings suggest that incorporating lymph fluid testing immediately after surgery, alongside plasma monitoring, could enable faster, more accurate decisions about follow-up treatment and improve outcomes for patients with HPV-independent head and neck cancer.

"These studies underscore the clinical utility of Labcorp Plasma Detect in advancing cancer research," said Shakti Ramkissoon, M.D., Ph.D., MBA, vice president and medical lead for oncology at Labcorp. "By demonstrating its ability to track early disease progression, predict long-term outcomes, and identify residual cancer in challenging contexts, our MRD technology provides critical insights that can inform future treatment strategies and improve understanding of tumor biology."

For more information on Labcorp's MRD portfolio, visit https://oncology.labcorp.com.

About Labcorp
Labcorp (NYSE: LH) is a global leader of innovative and comprehensive laboratory services that helps doctors, hospitals, pharmaceutical companies, researchers and patients make clear and confident decisions. We provide insights and advance science to improve health and improve lives through our unparalleled diagnostics and drug development laboratory capabilities. The company's nearly 70,000 employees serve clients in approximately 100 countries, provided support for more than 75% of the new drugs and therapeutic products approved in 2024 by the FDA, and perform more than 700 million tests annually for patients around the world. Learn more about us at www.labcorp.com.

 

SOURCE Labcorp

FAQ**

How does Labcorp’s Plasma Detect MRD technology, as reported in Nature Medicine and Clinical Cancer Research, improve the understanding of tumor biology for patients with rare cancers, specifically diffuse pleural mesothelioma, under Laboratory Corporation of America Holdings LH?

Labcorp’s Plasma Detect MRD technology enhances the understanding of tumor biology in rare cancers like diffuse pleural mesothelioma by providing precise, non-invasive detection of minimal residual disease, allowing for tailored treatment approaches and better patient outcomes.

In what ways can the findings on lymph fluid testing and plasma monitoring from the studies help enhance treatment strategies for head and neck cancer patients at Laboratory Corporation of America Holdings LH?

The findings on lymph fluid testing and plasma monitoring can enhance treatment strategies for head and neck cancer patients at Laboratory Corporation of America Holdings by enabling more personalized therapies, improved disease monitoring, and better prognostic assessments.

Considering the advancements showcased in these studies, how does Laboratory Corporation of America Holdings LH plan to integrate ctDNA monitoring into clinical practice to influence treatment decisions in oncology?

Laboratory Corporation of America Holdings (LH) plans to integrate ctDNA monitoring into clinical practice by leveraging advanced genomic technologies to provide real-time insights that inform treatment decisions, enhance patient outcomes, and refine personalized oncology strategies.

What implications do the studies' results have for the future of cancer research and patient outcomes, particularly in identifying residual disease, as highlighted by Laboratory Corporation of America Holdings LH?

The studies' results emphasize the need for advanced diagnostic techniques to effectively identify residual disease, potentially leading to more targeted therapies and improved patient outcomes, aligning with Laboratory Corporation of America Holdings' commitment to enhancing cancer research.

**MWN-AI FAQ is based on asking OpenAI questions about Laboratory Corporation of America Holdings (NYSE: LH).

Laboratory Corporation of America Holdings

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