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Pliant Therapeutics to Participate in the Piper Sandler Healthcare Conference

MWN-AI** Summary

Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage biotechnology firm specializing in integrin-based therapeutics, is set to participate in the Piper Sandler 37th Annual Healthcare Conference from December 2 to 4, 2025. Key executives, including President and CEO Dr. Bernard Coulie, CFO Dr. Keith Cummings, and Chief Medical Officer Dr. Éric Lefebvre, will take part in a fireside chat scheduled for December 4 at 12:30 p.m. Eastern Time. Interested audiences can access a live webcast of the discussion through the Investor Relations section on Pliant’s website, with an archived replay available for 90 days post-event.

Pliant Therapeutics focuses on the discovery and development of cutting-edge therapies targeting integrin receptors, which play a critical role in various disease processes. The company's lead candidate, PLN-101095, is a dual-selective small molecule inhibitor aimed at treating solid tumors by targeting specific integrins, namely ?v?8 and ?v?1. Additionally, Pliant is progressing with PLN-101325, a monoclonal antibody agonist for integrin ?7?1, designed for use in treating muscular dystrophies, and has already secured regulatory approval to initiate a Phase 1 clinical trial for this compound.

The company’s innovative early-stage platform is enhancing research into the tissue-specific delivery of therapeutic agents, leveraging integrin receptor-binding technologies to improve drug efficacy and safety. Investors and interested parties can follow Pliant on various social media platforms, including X, LinkedIn, and Facebook. For further details regarding their pipeline and corporate initiatives, visit Pliant's official website at www.PliantRx.com.

MWN-AI** Analysis

Pliant Therapeutics, Inc. (Nasdaq: PLRX) is making waves as it prepares to present at the Piper Sandler Healthcare Conference from December 2-4, 2025. With its focus on integrin-based therapeutics and promising lead programs, including PLN-101095 and PLN-101325, the company presents an interesting investment opportunity for those willing to delve into the biotech sector.

As a clinical-stage biotechnology company, Pliant is in a crucial development phase that can lead to significant market appreciation. PLN-101095, aimed at treating solid tumors, addresses a critical need in oncology, while PLN-101325’s potential application in muscular dystrophies expands the company’s reach. These key therapeutic targets are strategically aligned with high unmet medical needs, which can attract partnerships and increase investor interest.

Investors should keenly observe the strategic insights shared during the upcoming fireside chat featuring CEO Bernard Coulie and other executives. Such platforms not only provide an opportunity to acquire deeper knowledge about the company’s pipeline but can also influence stock performance based on investor sentiment and perceived growth prospects.

In the current volatile biotech landscape, investors should consider Pliant as a long-term play, especially if the upcoming regulatory developments and trial results remain positive. The upcoming Phase 1 study for PLN-101325 could serve as a catalyst, potentially driving share prices higher if the results align with investor expectations.

For those looking to establish a position in Pliant Therapeutics, it may be wise to monitor the stock closely post-conference for any shifts in market sentiment. With its solid therapeutic focus and an active developmental pipeline, Pliant Therapeutics warrants a spot on the radar of investors seeking growth in the biopharmaceutical sector.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

SOUTH SAN FRANCISCO, Dec. 01, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage biotechnology company focused on the discovery and development of integrin-based therapeutics, today announced its participation in the Piper Sandler 37 th Annual Healthcare Conference to be held December 2 – 4, 2025.

Bernard Coulie, M.D., Ph.D., President and Chief Executive Officer, Keith Cummings, M.D., Chief Financial Officer and Éric Lefebvre, M.D., Chief Medical Officer, will participate in a fireside chat on Thursday, December 4, 2025, at 12:30 p.m. Eastern Time.

Interested parties may access the live webcast of the fireside chat by visiting here or the Investor Relations’ Events & Presentation page of Pliant’s website. The webcast replay will be archived on the Pliant website for 90 days following the conclusion of the event.

About Pliant Therapeutics, Inc.

Pliant Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery and development of integrin-based therapeutics. The Company’s lead program is PLN-101095, a small molecule, dual-selective inhibitor of ? v ß 8 and ? v ß 1 integrins, that is being developed for the treatment of solid tumors. In addition, Pliant has received regulatory clearance for the conduct of a Phase 1 study of PLN-101325, a monoclonal antibody agonist of integrin ? 7 ? 1 targeting muscular dystrophies. Pliant’s early-stage platform includes preclinical research focused on tissue-specific delivery and internalization of drug payloads utilizing integrin receptor-binding molecules. For additional information, please visit: www.PliantRx.com . Follow us on social media X , LinkedIn and Facebook .

Investor and Media Contact:
Christopher Keenan
Vice President, Investor Relations and Corporate Communications
Pliant Therapeutics, Inc.
ir@pliantrx.com


FAQ**

What specific advancements or results can we expect from Pliant Therapeutics Inc. PLRX's lead program, PLN-101095, in treating solid tumors during the upcoming Phase 1 study?

In the upcoming Phase 1 study of PLN-101095, Pliant Therapeutics Inc. anticipates advancements in tumor shrinkage, improved safety profiles, and relevant preliminary efficacy data that could enhance treatment strategies for solid tumors.

How does Pliant Therapeutics Inc. PLRX plan to leverage its early-stage platform in integrin-based therapeutics to enhance the effectiveness of its treatments in muscular dystrophies?

Pliant Therapeutics Inc. plans to leverage its early-stage platform in integrin-based therapeutics by developing targeted therapies that enhance muscle strength and function in muscular dystrophies, potentially improving treatment efficacy and patient outcomes.

Can you provide insights on the anticipated timeline for clinical trial results for PLN-101325, the monoclonal antibody agonist, and how Pliant Therapeutics Inc. PLRX intends to approach the development process?

Pliant Therapeutics Inc. plans to expedite PLN-101325's development, aiming for clinical trial results in late 2024, while focusing on robust data collection and regulatory engagement to navigate the process efficiently.

What are Pliant Therapeutics Inc. PLRX's strategies for investor engagement following the Piper Sandler Healthcare Conference, and how will they communicate key updates from the event to stakeholders?

Pliant Therapeutics Inc. (PLRX) will enhance investor engagement post-Piper Sandler Healthcare Conference through targeted communications, including press releases and investor presentations, to convey key updates and strategies discussed during the event.

**MWN-AI FAQ is based on asking OpenAI questions about Pliant Therapeutics Inc. (NASDAQ: PLRX).

Pliant Therapeutics Inc.

NASDAQ: PLRX

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